[Term]
id: PR:000027889
name: signal transducer and activator of transcription 1 isoform 1 phosphorylated 3 (human)
def: "A signal transducer and activator of transcription 1 isoform 1 phosphorylated 3 in human. UniProtKB:P42224-1, Ser-727, MOD:00046." [PMID:15322115, PRO:PD]
comment: Category=organism-modification. Kinase=("PRKCD"; PR:Q05655; Ser-727).
synonym: "STAT1-pSer727" EXACT []
synonym: "hSTAT1/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P42224-1, Ser-727, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027888 ! signal transducer and activator of transcription 1 isoform 1 phosphorylated 3
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000027888
name: signal transducer and activator of transcription 1 isoform 1 phosphorylated 3
def: "A signal transducer and activator of transcription 1 isoform 1 phosphorylated form that has been modified on a Ser residue located in the conserved PMSP sequence at the C-terminal transactivation domain. Example: UniProtKB:P42224-1, Ser-727, MOD:00046." [PMID:15322115, PRO:PD]
comment: Category=modification.
synonym: "STAT1/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003075 ! signal transducer and activator of transcription 1 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:P42224
name: signal transducer and activator of transcription 1-alpha/beta (human)
def: "A signal transducer and activator of transcription 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P42224]
comment: Category=organism-gene.
synonym: "STAT1" RELATED Gene-based [UniProtKB:P42224]
synonym: "hSTAT1" EXACT PRO-short-label [PRO:DNx]
synonym: "transcription factor ISGF-3 components p91/p84 (human)" EXACT [UniProtKB:P42224]
xref: UniProtKB:P42224
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002087 ! signal transducer and activator of transcription 1
relationship: has_gene_template HGNC:11362 ! STAT1 (human)

[Term]
id: PR:P42224-1
name: signal transducer and activator of transcription 1 isoform 1 (human)
def: "A signal transducer and activator of transcription 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSTAT1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P42224-1
xref: Reactome:R-HSA-380745 "PR:P42224-1 located_in GO:0005829"
xref: Reactome:R-HSA-997294 "PR:P42224-1 located_in GO:0005654"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003073 ! signal transducer and activator of transcription 1 isoform 1

[Term]
id: PR:000027890
name: signal transducer and activator of transcription 1 isoform 1 sumoylated 1
def: "A signal transducer and activator of transcription 1 isoform 1 that has been modified on a Lys residue located right after the conserved GYI sequence in the C-terminal region. PIAS proteins promote this modification in response to IFN-gamma signaling. Example: UniProtKB:P42224-1, Lys-703, MOD:01149." [PMID:12855578, PRO:PD]
comment: Category=modification.
synonym: "STAT1/iso:1/Sumo:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003073 ! signal transducer and activator of transcription 1 isoform 1
relationship: has_part MOD:01149 ! sumoylated lysine

[Term]
id: PR:000002087
name: signal transducer and activator of transcription 1
def: "A signal transducer and transcription activator STAT that is a translation product of the human STAT1 gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "STAT1" EXACT PRO-short-label [PRO:DNx]
synonym: "transcription factor ISGF-3 components p91/p84" EXACT []
synonym: "Signal transducer and activator of transcription 1-alpha/beta" EXACT []
is_a: PR:000001933 ! signal transducer and transcription activator STAT

[Term]
id: PR:000003076
name: signal transducer and activator of transcription 1 isoform 1 phosphorylated 1
def: "A signal transducer and activator of transcription 1 isoform 1 phosphorylated form in which the phosphorylation occurs at the Tyr residue within the conserved GYI sequence following the SH2 domain. Example: UniProtKB:P42224-1, Tyr-701, MOD:00048." [PMID:7543024, PRO:CNA]
comment: Category=modification. Kinase=("JAK"; PR:000025748; Tyr-701).
synonym: "STAT1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "stat1 alpha active" EXACT []
synonym: "signal transducer and activator of transcription 1 isoform 1 phosphorylated 2" EXACT []
is_a: PR:000003075 ! signal transducer and activator of transcription 1 isoform 1 phosphorylated form
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000003077
name: signal transducer and activator of transcription 1 isoform 2
def: "A signal transducer and activator of transcription 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42224-2 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "STAT1 p84" RELATED []
synonym: "STAT1 beta" EXACT []
synonym: "STAT1/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002087 ! signal transducer and activator of transcription 1

[Term]
id: PR:000049364
name: signal transducer and activator of transcription 1-alpha/beta phosphorylated 1 (human)
def: "A signal transducer and activator of transcription 1-alpha/beta (human) that has been post-translationally modified to include phosphotyrosine at position 701 of the amino acid sequence represented by UniProtKB:P42224. UniProtKB:P42224, Tyr-701, MOD:00048." [PRO:DNx, Reactome:R-HSA-3132766]
comment: Category=organism-modification.
synonym: "hSTAT1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P42224, Tyr-701, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3132766 "PR:000049364 located_in GO:0005829"
xref: Reactome:R-HSA-6788624 "PR:000049364 located_in GO:0005654"
is_a: PR:P42224 ! signal transducer and activator of transcription 1-alpha/beta (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P42225
name: signal transducer and activator of transcription 1 (mouse)
def: "A signal transducer and activator of transcription 1 that is encoded in the genome of mouse." [OMA:P42225, PRO:DNx]
comment: Category=organism-gene.
synonym: "Stat1" RELATED Gene-based [UniProtKB:P42225]
synonym: "mSTAT1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P42225
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002087 ! signal transducer and activator of transcription 1
relationship: has_gene_template MGI:103063 ! Stat1 (mouse)

[Term]
id: PR:000026858
name: signal transducer and activator of transcription 1 isoform 1 phosphorylated 1 (human)
def: "A signal transducer and activator of transcription 1 isoform 1 phosphorylated 1 in human. UniProtKB:P42224-1, Tyr-701, MOD:00048." [PMID:7657660, PRO:CNA, Reactome:R-HSA-873791, Reactome:R-HSA-909684]
comment: Category=organism-modification.
synonym: "hSTAT1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P42224-1, Tyr-701, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "signal transducer and activator of transcription 1 isoform 1 phosphorylated 2 (human)" EXACT []
xref: Reactome:R-HSA-873791 "PR:000026858 located_in GO:0005829"
xref: Reactome:R-HSA-909684 "PR:000026858 located_in GO:0005654"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003076 ! signal transducer and activator of transcription 1 isoform 1 phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:P42224-2
name: signal transducer and activator of transcription 1-alpha/beta isoform Beta (human)
def: "A signal transducer and activator of transcription 1 isoform 2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSTAT1/iso:Beta" EXACT PRO-short-label [PRO:DNx]
synonym: "signal transducer and activator of transcription 1-alpha/beta isoform p84 (human)" EXACT [UniProtKB:P42224]
xref: UniProtKB:P42224-2
xref: Reactome:R-HSA-380741 "PR:P42224-2 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003077 ! signal transducer and activator of transcription 1 isoform 2

[Term]
id: PR:Q99K94
name: signal transducer and activator of transcription isoform 2 (mouse)
def: "A signal transducer and activator of transcription 1 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mSTAT1/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99K94
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003077 ! signal transducer and activator of transcription 1 isoform 2

[Term]
id: PR:000049976
name: signal transducer and activator of transcription 1 phosphorylated 1 (mouse)
def: "A signal transducer and activator of transcription 1 (mouse) that has been phosphorylated at Tyr-701 within the conserved GYI sequence following the SH2 domain. UniProtKB:P42225, Tyr-701, MOD:00048." [PMID:27671227, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27671227)
synonym: "mSTAT1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P42225, Tyr-701, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P42225 ! signal transducer and activator of transcription 1 (mouse)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P42225-1
name: signal transducer and activator of transcription 1 isoform 1 (mouse)
def: "A signal transducer and activator of transcription 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mSTAT1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P42225-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003073 ! signal transducer and activator of transcription 1 isoform 1

[Term]
id: PR:000003075
name: signal transducer and activator of transcription 1 isoform 1 phosphorylated form
def: "A signal transducer and activator of transcription 1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "STAT1/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000003073 ! signal transducer and activator of transcription 1 isoform 1

[Term]
id: PR:000049977
name: signal transducer and activator of transcription 1 unphosphorylated 1 (mouse)
def: "A signal transducer and activator of transcription 1 (mouse) that lacks phosphorylation at Tyr-701 within the conserved GYI sequence following the SH2 domain. UniProtKB:P42225, Tyr-701, PR:000026291." [PMID:27671227, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27671227).
synonym: "mSTAT1/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P42225, Tyr-701, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P42225 ! signal transducer and activator of transcription 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000027891
name: signal transducer and activator of transcription 1 isoform 1 sumoylated 1 (human)
def: "A signal transducer and activator of transcription 1 isoform 1 sumoylated 1 in human. UniProtKB:P42224-1, Lys-703, MOD:01149." [PMID:12855578, PRO:PD]
comment: Category=organism-modification. Sumoylase=("SUMO1"; PR:000015829).
synonym: "STAT1-suLys703" EXACT []
synonym: "hSTAT1/iso:1/Sumo:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P42224-1, Lys-703, MOD:01149" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027890 ! signal transducer and activator of transcription 1 isoform 1 sumoylated 1
relationship: has_part MOD:01149 ! sumoylated lysine

[Term]
id: PR:000028636
name: signal transducer and activator of transcription 1 isoform 1 acetylated 1
def: "A signal transducer and activator of transcription 1 isoform 1 that has been acetylated on Lys residues within the DNA binding domain. Example: UniProtKB:P42224-1, Lys-410/Lys-413, MOD:00064." [PMID:16481475, PRO:PD]
comment: Category=modification.
synonym: "STAT1/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003073 ! signal transducer and activator of transcription 1 isoform 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000003073
name: signal transducer and activator of transcription 1 isoform 1
def: "A signal transducer and activator of transcription 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42224-1 or a 1:1 ortholog thereof." [PMID:1502203, PRO:CNA]
comment: Category=sequence.
synonym: "STAT1 p91" RELATED []
synonym: "STAT1 alpha" EXACT []
synonym: "STAT1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002087 ! signal transducer and activator of transcription 1

[Term]
id: PR:000028637
name: signal transducer and activator of transcription 1 isoform 1 acetylated 1 (human)
def: "A signal transducer and activator of transcription 1 isoform 1 acetylated 1 in human. UniProtKB:P42224-1, Lys-410/Lys-413, MOD:00064." [PMID:16481475, PRO:PD]
comment: Category=organism-modification. Acetylase=("CREBBP"; PR:Q92793).
synonym: "hSTAT1/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P42224-1, Lys-410/Lys-413, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028636 ! signal transducer and activator of transcription 1 isoform 1 acetylated 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine