[Term]
id: PR:000002065
name: mast/stem cell growth factor receptor
def: "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human KIT gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene. Requested by=CL.
synonym: "Sl" RELATED Gene-based []
synonym: "KIT" EXACT PRO-short-label [PRO:DNx]
synonym: "SCFR" RELATED Gene-based []
synonym: "CD117" EXACT []
synonym: "proto-oncogene c-Kit" EXACT []
synonym: "tyrosine-protein kinase Kit" EXACT []
xref: IUPHARobj:1805
xref: PIRSF:PIRSF500951
is_a: PR:000001810 ! CSF-1/PDGF receptor-type tyrosine-protein kinase

[Term]
id: PR:P10721
name: mast/stem cell growth factor receptor Kit (human)
def: "A mast/stem cell growth factor receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:P10721]
comment: Category=organism-gene.
synonym: "KIT" RELATED Gene-based [UniProtKB:P10721]
synonym: "SCFR" RELATED Gene-based [UniProtKB:P10721]
synonym: "hKIT" EXACT PRO-short-label [PRO:DNx]
synonym: "PBT (human)" EXACT [UniProtKB:P10721]
synonym: "CD117 (human)" EXACT [UniProtKB:P10721]
synonym: "p145 c-kit (human)" EXACT [UniProtKB:P10721]
synonym: "proto-oncogene c-Kit (human)" EXACT [UniProtKB:P10721]
synonym: "piebald trait protein (human)" EXACT [UniProtKB:P10721]
synonym: "tyrosine-protein kinase Kit (human)" EXACT [UniProtKB:P10721]
synonym: "v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (human)" EXACT [UniProtKB:P10721]
xref: DTO:03100231
xref: UniProtKB:P10721
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002065 ! mast/stem cell growth factor receptor
relationship: has_gene_template HGNC:6342 ! KIT (human)

[Term]
id: PR:P10721-2
name: mast/stem cell growth factor receptor Kit isoform h2 (human)
def: "A mast/stem cell growth factor receptor Kit (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10721-2." [PRO:DNx, UniProtKB:P10721]
comment: Category=organism-sequence.
synonym: "hKIT/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "mast/stem cell growth factor receptor Kit isoform GNNK(-) (human)" EXACT [UniProtKB:P10721]
xref: UniProtKB:P10721-2
is_a: PR:P10721 ! mast/stem cell growth factor receptor Kit (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048127
name: mast/stem cell growth factor receptor Kit, signal peptide removed form (human)
def: "A mast/stem cell growth factor receptor Kit (human) that has had the signal peptide removed. UniProtKB:P10721, 26-976." [PRO:DNx, Reactome:R-HSA-197662]
comment: Category=organism-modification.
synonym: "hKIT/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000016754" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P10721, 26-976" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-197662 "PR:000048127 located_in GO:0005886"
intersection_of: PR:P10721 ! mast/stem cell growth factor receptor Kit (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000054793
name: mast/stem cell growth factor receptor Kit N-glycosylated 1 (human)
def: "A mast/stem cell growth factor receptor Kit (human) that has been N-glycosylated at the residue equivalent to Asn-130 of the amino acid sequence represented by UniProtKB:P10721-1, in which the glycan composition is represented by GlyTouCan:G59626AS. Example: UniProtKB:P10721-1, Asn-130, MOD:00160~GNO:G59626AS." [GlyGen:P10721-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hKIT/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P10721-1, Asn-130, MOD:00160~GNO:G59626AS" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P10721 ! mast/stem cell growth factor receptor Kit (human)
relationship: has_part GNO:G59626AS ! G59626AS
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048130
name: mast/stem cell growth factor receptor Kit, signal peptide removed phosphorylated 3 (human)
def: "A mast/stem cell growth factor receptor Kit (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 568, 570, 703, 721, 730, 823 and 936 of the amino acid sequence represented by UniProtKB:P10721. UniProtKB:P10721, 26-976, Tyr-568/Tyr-570/Tyr-703/Tyr-721/Tyr-730/Tyr-823/Tyr-936, MOD:00048." [PRO:DNx, Reactome:R-HSA-205207]
comment: Category=organism-modification.
synonym: "hKIT/SigPep-/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000016754, Tyr-568/Tyr-570/Tyr-703/Tyr-721/Tyr-730/Tyr-823/Tyr-936, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P10721, 26-976, Tyr-568/Tyr-570/Tyr-703/Tyr-721/Tyr-730/Tyr-823/Tyr-936, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-205207 "PR:000048130 located_in GO:0005886"
is_a: PR:P10721 ! mast/stem cell growth factor receptor Kit (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:P10721-4
name: mast/stem cell growth factor receptor Kit isoform h3 (human)
def: "A mast/stem cell growth factor receptor Kit (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10721-4." [PRO:DNx, UniProtKB:P10721]
comment: Category=organism-sequence.
synonym: "hKIT/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "mast/stem cell growth factor receptor Kit isoform TR-KIT (human)" EXACT [UniProtKB:P10721]
xref: UniProtKB:P10721-4
is_a: PR:P10721 ! mast/stem cell growth factor receptor Kit (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049999
name: mast/stem cell growth factor receptor Kit sequence variant D816V (human)
def: "A mast/stem cell growth factor receptor Kit (human) that has a Val residue at the position equivalent to Asp-816 of the amino acid sequence represented by UniProtKB:P10721-1. Example: UniProtKB:P10721-1, Asp-816, CHEBI:30015." [PRO:DAN]
comment: Category=organism-sequence.
synonym: "hKIT/var:D816V" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:P10721-1, Asp-816, CHEBI:30015" NARROW PRO-proteoform-std [PRO:DAN]
xref: UniProtKB_VAR:VAR_004109
is_a: PR:P10721 ! mast/stem cell growth factor receptor Kit (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P10721-1
name: mast/stem cell growth factor receptor Kit isoform 1 (human)
def: "A mast/stem cell growth factor receptor Kit (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10721-1." [PRO:DNx, UniProtKB:P10721]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hKIT/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "mast/stem cell growth factor receptor Kit isoform GNNK(+) (human)" EXACT [UniProtKB:P10721]
xref: UniProtKB:P10721-1
is_a: PR:P10721 ! mast/stem cell growth factor receptor Kit (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048129
name: mast/stem cell growth factor receptor Kit, signal peptide removed phosphorylated 2 (human)
def: "A mast/stem cell growth factor receptor Kit (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 568, 570, 703, 721, 730, 823, 900 and 936 of the amino acid sequence represented by UniProtKB:P10721. UniProtKB:P10721, 26-976, Tyr-568/Tyr-570/Tyr-703/Tyr-721/Tyr-730/Tyr-823/Tyr-900/Tyr-936, MOD:00048." [PRO:DNx, Reactome:R-HSA-1472116]
comment: Category=organism-modification.
synonym: "hKIT/SigPep-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000016754, Tyr-568/Tyr-570/Tyr-703/Tyr-721/Tyr-730/Tyr-823/Tyr-900/Tyr-936, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P10721, 26-976, Tyr-568/Tyr-570/Tyr-703/Tyr-721/Tyr-730/Tyr-823/Tyr-900/Tyr-936, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1472116 "PR:000048129 located_in GO:0005886"
is_a: PR:P10721 ! mast/stem cell growth factor receptor Kit (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000048128
name: mast/stem cell growth factor receptor Kit, signal peptide removed phosphorylated 1 (human)
def: "A mast/stem cell growth factor receptor Kit (human) that has had the signal peptide removed and has been post-translationally modified to include phosphoserine at positions 741 and 746 of the amino acid sequence represented by UniProtKB:P10721. UniProtKB:P10721, 26-976, Ser-741/Ser-746, MOD:00046." [PRO:DNx, Reactome:R-HSA-1433492]
comment: Category=organism-modification.
synonym: "hKIT/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000016754, Ser-741/Ser-746, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P10721, 26-976, Ser-741/Ser-746, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1433492 "PR:000048128 located_in GO:0005886"
is_a: PR:P10721 ! mast/stem cell growth factor receptor Kit (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide