[Term]
id: PR:000048049
name: interferon regulatory factor 7 phosphorylated 1 (human)
def: "An interferon regulatory factor 7 (human) that has been post-translationally modified to include phosphoserine at positions 477 and 479 of the amino acid sequence represented by UniProtKB:Q92985. UniProtKB:Q92985, Ser-477/Ser-479, MOD:00046." [PRO:DNx, Reactome:R-HSA-450270, Reactome:R-HSA-450318]
comment: Category=organism-modification.
synonym: "hIRF7/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q92985, Ser-477/Ser-479, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-450270 "PR:000048049 located_in GO:0005654"
xref: Reactome:R-HSA-450318 "PR:000048049 located_in GO:0005829"
is_a: PR:Q92985 ! interferon regulatory factor 7 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000003281
name: interferon regulatory factor 7 isoform 1 phosphorylated 1
def: "An interferon regulatory factor 7 isoform 1 phosphorylated form that has been activated by phosphorylation on the Ser residues located in the C-terminal region. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit. Example: UniProtKB:Q92985-1, Ser-477/Ser-479, MOD:00046." [PMID:10893229, PMID:14517278, PMID:20043992, TLR:AMM]
comment: Category=modification. Requested by=TLR.
synonym: "phospho IRF7" EXACT []
synonym: "IRF-7 active form" EXACT []
synonym: "IRF7/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "IRF-7 phosphorylated" EXACT []
is_a: PR:000003280 ! interferon regulatory factor 7 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000003280
name: interferon regulatory factor 7 isoform 1 phosphorylated form
def: "An interferon regulatory factor 7 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification. Requested by=TLR.
synonym: "IRF7/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000003261 ! interferon regulatory factor 7 isoform 1

[Term]
id: PR:Q92985-1
name: interferon regulatory factor 7 isoform A (human)
def: "An interferon regulatory factor 7 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hIRF7/iso:A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q92985-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003261 ! interferon regulatory factor 7 isoform 1

[Term]
id: PR:000002049
name: interferon regulatory factor 7
def: "An interferon regulatory factor 3-9 that is a translation product of the human IRF7 gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "IRF7" EXACT PRO-short-label [PRO:DNx]
synonym: "IRF-7" EXACT []
is_a: PR:000001863 ! interferon regulatory factor 3-9

[Term]
id: PR:000003261
name: interferon regulatory factor 7 isoform 1
def: "An interferon regulatory factor 7 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92985-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "IRF7/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002049 ! interferon regulatory factor 7

[Term]
id: PR:000037790
name: interferon regulatory factor 7 isoform 1 unphosphorylated 1
def: "An interferon regulatory factor 7 isoform 1 that lacks phosphorylation on the Ser residues located in the C-terminal region that actives dimerization. Example: UniProtKB:Q92985-1, Ser-477/Ser-479, PR:000026291." [PMID:10893229, PMID:14517278, PMID:20043992, PRO:CNA]
comment: Category=modification.
synonym: "IRF7/iso:1/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "IRF7 unphosphorylated 1" EXACT []
is_a: PR:000003261 ! interferon regulatory factor 7 isoform 1

[Term]
id: PR:000027082
name: interferon regulatory factor 7 isoform 1 phosphorylated 1 (human)
def: "An interferon regulatory factor 7 isoform 1 phosphorylated 1 in human. UniProtKB:Q92985-1, Ser-477/Ser-479, MOD:00046." [PMID:10893229, PMID:14517278, TLR:AMM]
comment: Category=organism-modification. Requested by=TLR.
synonym: "hIRF7/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "phospho IRF7 (human)" EXACT []
synonym: "IRF-7 active form (human)" EXACT []
synonym: "IRF-7 phosphorylated (human)" EXACT []
synonym: "UniProtKB:Q92985-1, Ser-477/Ser-479, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003281 ! interferon regulatory factor 7 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:Q92985-2
name: interferon regulatory factor 7 isoform B (human)
def: "An interferon regulatory factor 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92985-2." [PRO:DNx, UniProtKB:Q92985]
comment: Category=organism-sequence.
synonym: "hIRF7/iso:B" EXACT PRO-short-label [PRO:DNx]
synonym: "interferon regulatory factor 7 isoform Beta (human)" EXACT [UniProtKB:Q92985]
xref: UniProtKB:Q92985-2
is_a: PR:Q92985 ! interferon regulatory factor 7 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000037791
name: interferon regulatory factor 7 isoform 1 unphosphorylated 1 (human)
def: "An interferon regulatory factor 7 isoform 1 unphosphorylated 1 in human. UniProtKB:Q92985-1, Ser-477/Ser-479, PR:000026291." [PMID:10893229, PMID:14517278, PRO:CNA]
comment: Category=organism-modification. Requested by=TLR.
synonym: "hIRF7/iso:1/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "IRF-7 unphosphorylated (human)" RELATED []
synonym: "UniProtKB:Q92985-1, Ser-477/Ser-479, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000037790 ! interferon regulatory factor 7 isoform 1 unphosphorylated 1

[Term]
id: PR:Q92985-4
name: interferon regulatory factor 7 isoform D (human)
def: "An interferon regulatory factor 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92985-4." [PRO:DNx, UniProtKB:Q92985]
comment: Category=organism-sequence.
synonym: "hIRF7/iso:D" EXACT PRO-short-label [PRO:DNx]
synonym: "interferon regulatory factor 7 isoform H (human)" EXACT [UniProtKB:Q92985]
xref: UniProtKB:Q92985-4
is_a: PR:Q92985 ! interferon regulatory factor 7 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q92985
name: interferon regulatory factor 7 (human)
def: "An interferon regulatory factor 7 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q92985]
comment: Category=organism-gene.
synonym: "IRF7" RELATED Gene-based [UniProtKB:Q92985]
synonym: "hIRF7" EXACT PRO-short-label [PRO:DNx]
synonym: "IRF-7 (human)" EXACT [UniProtKB:Q92985]
xref: UniProtKB:Q92985
xref: Reactome:R-HSA-450274 "PR:Q92985 located_in GO:0010008"
xref: Reactome:R-HSA-450281 "PR:Q92985 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002049 ! interferon regulatory factor 7
relationship: has_gene_template HGNC:6122 ! IRF7 (human)

[Term]
id: PR:000048050
name: interferon regulatory factor 7 ubiquitinated form (human)
def: "An interferon regulatory factor 7 (human) that includes at least one ubiquitinated lysine. UniProtKB:Q92985, MOD:01148." [PRO:DNx, Reactome:R-HSA-975154]
comment: Category=organism-modification.
synonym: "hIRF7/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q92985, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-975154 "PR:000048050 located_in GO:0010008"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:Q92985 ! interferon regulatory factor 7 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000028704
name: interferon regulatory factor 7 unmodified form (human)
def: "An interferon regulatory factor 7 unmodified form in human." [PRO:CNA]
comment: Category=organism-modification.
synonym: "hIRF7/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028703 ! interferon regulatory factor 7 unmodified form

[Term]
id: PR:Q92985-3
name: interferon regulatory factor 7 isoform C (human)
def: "An interferon regulatory factor 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92985-3." [PRO:DNx, UniProtKB:Q92985]
comment: Category=organism-sequence.
synonym: "hIRF7/iso:C" EXACT PRO-short-label [PRO:DNx]
synonym: "interferon regulatory factor 7 isoform Gamma (human)" EXACT [UniProtKB:Q92985]
xref: UniProtKB:Q92985-3
is_a: PR:Q92985 ! interferon regulatory factor 7 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000028703
name: interferon regulatory factor 7 unmodified form
def: "An interferon regulatory factor 7 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:CNA]
comment: Category=modification.
synonym: "IRF7/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000002049 ! interferon regulatory factor 7
intersection_of: has_part PR:000021935 ! immature protein part
intersection_of: lacks_part PR:000025513 ! modified amino-acid residue
disjoint_from: PR:000018264 ! proteolytic cleavage product

[Term]
id: PR:P70434
name: interferon regulatory factor 7 (mouse)
def: "An interferon regulatory factor 7 that is encoded in the genome of mouse." [OMA:P70434, PRO:CNA]
comment: Category=organism-gene. Requested by=TLR.
synonym: "Irf7" RELATED Gene-based [UniProtKB:P70434]
synonym: "mIRF7" EXACT PRO-short-label [PRO:DNx]
synonym: "IRF-7 (mouse)" EXACT []
xref: UniProtKB:P70434
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002049 ! interferon regulatory factor 7
relationship: has_gene_template MGI:1859212 ! Irf7 (mouse)