[Term]
id: PR:000002042
name: integrin beta-3
def: "An integrin beta that is a translation product of the human ITGB3 gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "CD61" EXACT []
synonym: "GP3A" RELATED Gene-based []
synonym: "ITGB3" EXACT PRO-short-label [PRO:DNx]
synonym: "GPIIIa" EXACT []
synonym: "platelet membrane glycoprotein IIIa" EXACT []
xref: IUPHARobj:2457
xref: PANTHER:PTHR10082:SF10
is_a: PR:000001861 ! integrin beta

[Term]
id: PR:000041631
name: integrin beta-3, signal peptide removed form (human)
def: "An integrin beta-3 (human) that has the signal peptide removed. Example: UniProtKB:P05106-1, 27-788." [PRO:DAN]
comment: Category=organism-modification.
synonym: "PRO_0000016344" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "hITGB3/SigPep-" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:P05106-1, 27-788" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-57600 "PR:000041631 located_in GO:0005886"
intersection_of: PR:P05106 ! integrin beta-3 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P05106
name: integrin beta-3 (human)
def: "An integrin beta-3 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "GP3A" RELATED Gene-based [UniProtKB:P05106]
synonym: "ITGB3" RELATED Gene-based [UniProtKB:P05106]
synonym: "hITGB3" EXACT PRO-short-label [PRO:DNx]
synonym: "CD61 (human)" EXACT [UniProtKB:P05106]
synonym: "GPIIIa (human)" EXACT [UniProtKB:P05106]
synonym: "platelet membrane glycoprotein IIIa (human)" EXACT [UniProtKB:P05106]
xref: UniProtKB:P05106
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002042 ! integrin beta-3
relationship: has_gene_template HGNC:6156 ! ITGB3 (human)

[Term]
id: PR:000048069
name: integrin beta-3, signal peptide removed phosphorylated 1 (human)
def: "An integrin beta-3, signal peptide removed form (human) that has been post-translationally modified to include phosphothreonine at position 779 of the amino acid sequence represented by UniProtKB:P05106. UniProtKB:P05106, 27-788, Thr-779, MOD:00047." [PRO:DNx, Reactome:R-HSA-432107]
comment: Category=organism-modification.
synonym: "hITGB3/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000016344, Thr-779, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P05106, 27-788, Thr-779, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-432107 "PR:000048069 located_in GO:0005886"
is_a: PR:000041631 ! integrin beta-3, signal peptide removed form (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000053451
name: integrin beta-3 N-glycosylated 2 (human)
def: "An integrin beta-3 (human) that has been N-glycosylated at the residue equivalent to Asn-125 of the amino acid sequence represented by UniProtKB:P05106-1, in which the glycan composition is represented by GlyTouCan:G59626AS. Example: UniProtKB:P05106-1, Asn-125, MOD:00160~GNO:G59626AS." [GlyGen:P05106-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hITGB3/NGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P05106-1, Asn-125, MOD:00160~GNO:G59626AS" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P05106 ! integrin beta-3 (human)
relationship: has_part GNO:G59626AS ! G59626AS
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000053450
name: integrin beta-3 N-glycosylated 1 (human)
def: "An integrin beta-3 (human) that has been N-glycosylated at the residue equivalent to Asn-125 of the amino acid sequence represented by UniProtKB:P05106-1, in which the glycan composition is represented by GlyTouCan:G00912UN. Example: UniProtKB:P05106-1, Asn-125, MOD:00160~GNO:G00912UN." [GlyGen:P05106-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hITGB3/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P05106-1, Asn-125, MOD:00160~GNO:G00912UN" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P05106 ! integrin beta-3 (human)
relationship: has_part GNO:G00912UN ! G00912UN
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P05106-1
name: integrin beta-3 isoform hBeta-3A (human)
def: "An integrin beta-3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05106-1." [PRO:DNx, UniProtKB:P05106]
comment: Category=organism-sequence.
synonym: "hITGB3/iso:hBeta-3A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P05106-1
is_a: PR:P05106 ! integrin beta-3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P05106-2
name: integrin beta-3 isoform hBeta-3B (human)
def: "An integrin beta-3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05106-2." [PRO:DNx, UniProtKB:P05106]
comment: Category=organism-sequence.
synonym: "hITGB3/iso:hBeta-3B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P05106-2
is_a: PR:P05106 ! integrin beta-3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P05106-3
name: integrin beta-3 isoform hBeta-3C (human)
def: "An integrin beta-3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05106-3." [PRO:DNx, UniProtKB:P05106]
comment: Category=organism-sequence.
synonym: "hITGB3/iso:hBeta-3C" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P05106-3
is_a: PR:P05106 ! integrin beta-3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens