[Term]
id: PR:000001968
name: tyrosine-protein phosphatase non-receptor type substrate 1
def: "A SIRP/SHPS-1 family protein that is a translation product of the human SIRPA gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene. Requested by=CL.
synonym: "BIT" RELATED Gene-based []
synonym: "Bit" EXACT []
synonym: "MFR" RELATED Gene-based []
synonym: "p84" BROAD [PRO:DNx]
synonym: "MYD1" RELATED Gene-based []
synonym: "SIRP" RELATED Gene-based []
synonym: "SHPS1" RELATED Gene-based []
synonym: "SIRPA" EXACT PRO-short-label [PRO:DNx]
synonym: "CD172a" EXACT []
synonym: "PTPNS1" RELATED Gene-based []
synonym: "SHPS-1" EXACT []
synonym: "Sirp-alpha-1" EXACT []
synonym: "Sirp-alpha-2" EXACT []
synonym: "Sirp-alpha-3" EXACT []
synonym: "MyD-1 antigen" EXACT []
synonym: "SHP substrate 1" EXACT []
synonym: "inhibitory receptor SHPS-1" EXACT []
synonym: "macrophage fusion receptor" EXACT []
synonym: "signal-regulatory protein alpha-1" EXACT []
synonym: "signal-regulatory protein alpha-2" EXACT []
synonym: "signal-regulatory protein alpha-3" EXACT []
synonym: "CD172 antigen-like family member A" EXACT []
synonym: "brain Ig-like molecule with tyrosine-based activation motifs" EXACT []
xref: IUPHARobj:2942
is_a: PR:000001832 ! SIRP/SHPS-1 family protein

[Term]
id: PR:P78324-2
name: tyrosine-protein phosphatase non-receptor type substrate 1 isoform h2 (human)
def: "A tyrosine-protein phosphatase non-receptor type substrate 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P78324-2." [PRO:DNx, UniProtKB:P78324]
comment: Category=organism-sequence.
synonym: "hSIRPA/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P78324-2
is_a: PR:P78324 ! tyrosine-protein phosphatase non-receptor type substrate 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P78324
name: tyrosine-protein phosphatase non-receptor type substrate 1 (human)
def: "A tyrosine-protein phosphatase non-receptor type substrate 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P78324]
comment: Category=organism-gene.
synonym: "BIT" RELATED Gene-based [UniProtKB:P78324]
synonym: "MFR" RELATED Gene-based [UniProtKB:P78324]
synonym: "MYD1" RELATED Gene-based [UniProtKB:P78324]
synonym: "SIRP" RELATED Gene-based [UniProtKB:P78324]
synonym: "SHPS1" RELATED Gene-based [UniProtKB:P78324]
synonym: "SIRPA" RELATED Gene-based [UniProtKB:P78324]
synonym: "PTPNS1" RELATED Gene-based [UniProtKB:P78324]
synonym: "hSIRPA" EXACT PRO-short-label [PRO:DNx]
synonym: "p84 (human)" BROAD [UniProtKB:P78324]
synonym: "CD172a (human)" EXACT [UniProtKB:P78324]
synonym: "SHPS-1 (human)" EXACT [UniProtKB:P78324]
synonym: "Sirp-alpha-1 (human)" EXACT [UniProtKB:P78324]
synonym: "Sirp-alpha-2 (human)" EXACT [UniProtKB:P78324]
synonym: "Sirp-alpha-3 (human)" EXACT [UniProtKB:P78324]
synonym: "MyD-1 antigen (human)" EXACT [UniProtKB:P78324]
synonym: "SHP substrate 1 (human)" EXACT [UniProtKB:P78324]
synonym: "inhibitory receptor SHPS-1 (human)" EXACT [UniProtKB:P78324]
synonym: "macrophage fusion receptor (human)" EXACT [UniProtKB:P78324]
synonym: "signal-regulatory protein alpha-1 (human)" EXACT [UniProtKB:P78324]
synonym: "signal-regulatory protein alpha-2 (human)" EXACT [UniProtKB:P78324]
synonym: "signal-regulatory protein alpha-3 (human)" EXACT [UniProtKB:P78324]
synonym: "CD172 antigen-like family member A (human)" EXACT [UniProtKB:P78324]
synonym: "brain Ig-like molecule with tyrosine-based activation motifs (human)" EXACT [UniProtKB:P78324]
xref: UniProtKB:P78324
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1
relationship: has_gene_template HGNC:9662 ! SIRPA (human)

[Term]
id: PR:P78324-4
name: tyrosine-protein phosphatase non-receptor type substrate 1 isoform h4 (human)
def: "A tyrosine-protein phosphatase non-receptor type substrate 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P78324-4." [PRO:DNx, UniProtKB:P78324]
comment: Category=organism-sequence.
synonym: "hSIRPA/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P78324-4
is_a: PR:P78324 ! tyrosine-protein phosphatase non-receptor type substrate 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049250
name: tyrosine-protein phosphatase non-receptor type substrate 1, signal peptide removed form (human)
def: "A tyrosine-protein phosphatase non-receptor type substrate 1 (human) that has had the signal peptide removed. UniProtKB:P78324, 31-504." [PRO:DNx, Reactome:R-HSA-3209922]
comment: Category=organism-modification.
synonym: "PRO_0000014941" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hSIRPA/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P78324, 31-504" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3209922 "PR:000049250 located_in GO:0005886"
xref: Reactome:R-HSA-6803288 "PR:000049250 located_in GO:0070821"
xref: Reactome:R-HSA-6803321 "PR:000049250 located_in GO:0101003"
intersection_of: PR:P78324 ! tyrosine-protein phosphatase non-receptor type substrate 1 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000056678
name: tyrosine-protein phosphatase non-receptor type substrate 1 N-glycosylated 2 (human)
def: "A tyrosine-protein phosphatase non-receptor type substrate 1 (human) that has been N-glycosylated at the residue equivalent to Asn-292 of the amino acid sequence represented by UniProtKB:P78324-1, in which the glycan composition is represented by GlyTouCan:G82364UA. Example: UniProtKB:P78324-1, Asn-292, MOD:00160~GNO:G82364UA." [GlyGen:P78324-1, PMID:23345538, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hSIRPA/NGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P78324-1, Asn-292, MOD:00160~GNO:G82364UA" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P78324 ! tyrosine-protein phosphatase non-receptor type substrate 1 (human)
relationship: has_part GNO:G82364UA ! G82364UA
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000026555
name: tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1, signal peptide removed phosphorylated 1 (human)
def: "A tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P78324-1, 31-504, Tyr-429/Tyr-453/Tyr-470/Tyr-496, MOD:00048." [PRO:CNA]
comment: Category=organism-modification.
synonym: "phosphorylated SIRP-A" EXACT []
synonym: "hSIRPA/iso:1/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000014941, Tyr-429/Tyr-453/Tyr-470/Tyr-496, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P78324-1, 31-504, Tyr-429/Tyr-453/Tyr-470/Tyr-496, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-391102 "PR:000026555 located_in GO:0005886"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026554 ! tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1, signal peptide removed phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:P78324-1
name: tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 (human)
def: "A tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSIRPA/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P78324-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026551 ! tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1

[Term]
id: PR:000056677
name: tyrosine-protein phosphatase non-receptor type substrate 1 N-glycosylated 1 (human)
def: "A tyrosine-protein phosphatase non-receptor type substrate 1 (human) that has been N-glycosylated at the residue equivalent to Asn-292 of the amino acid sequence represented by UniProtKB:P78324-1, in which the glycan composition is represented by GlyTouCan:G01650EU. Example: UniProtKB:P78324-1, Asn-292, MOD:00160~GNO:G01650EU." [GlyGen:P78324-1, PMID:23345538, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hSIRPA/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P78324-1, Asn-292, MOD:00160~GNO:G01650EU" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P78324 ! tyrosine-protein phosphatase non-receptor type substrate 1 (human)
relationship: has_part GNO:G01650EU ! G01650EU
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens