[Term]
id: PR:000001943
name: transcription factor E2-alpha
def: "A protein that is a translation product of the human TCF3 gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "E2A" RELATED Gene-based []
synonym: "Me2" RELATED Gene-based []
synonym: "Alf2" RELATED Gene-based []
synonym: "ITF1" RELATED Gene-based []
synonym: "TCF3" EXACT PRO-short-label [PRO:DNx]
synonym: "TCF-3" RELATED []
synonym: "Tcfe2a" RELATED Gene-based []
synonym: "BHLHB21" RELATED Gene-based []
synonym: "bHLHb21" EXACT []
synonym: "transcription factor 3" EXACT []
synonym: "kappa-E2-binding factor" EXACT []
synonym: "transcription factor A1" EXACT []
synonym: "transcription factor ITF-1" EXACT []
synonym: "immunoglobulin transcription factor 1" EXACT []
synonym: "class B basic helix-loop-helix protein 21" EXACT []
synonym: "immunoglobulin enhancer-binding factor E12/E47" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000049407
name: transcription factor E2-alpha phosphorylated 2 (human)
def: "A transcription factor E2-alpha (human) that has been post-translationally modified to include phosphoserine at position 139 of the amino acid sequence represented by UniProtKB:P15923. UniProtKB:P15923, Ser-139, MOD:00046." [PRO:DNx, Reactome:R-HSA-3209894]
comment: Category=organism-modification.
synonym: "hTCF3/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P15923, Ser-139, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3209894 "PR:000049407 located_in GO:0005654"
is_a: PR:P15923 ! transcription factor E2-alpha (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045685
name: transcription factor E2-alpha phosphorylated 1 (human)
def: "A transcription factor E2-alpha (human) that has been phosphorylated at the position equivalent to Ser-39 of the amino acid sequence represented by UniProtKB:P15923-1. Example: UniProtKB:P15923-1, Ser-39, MOD:00046." [PMID:26212009, iPTMnet:P15923]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:26212009). Status=unreviewed.
synonym: "hTCF3/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P15923-1, Ser-39, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P15923 ! transcription factor E2-alpha (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P15923
name: transcription factor E2-alpha (human)
def: "A transcription factor E2-alpha that is encoded in the genome of human." [PRO:WCB, UniProtKB:P15923]
comment: Category=organism-gene.
synonym: "E2A" RELATED Gene-based [UniProtKB:P15923]
synonym: "ITF1" RELATED Gene-based [UniProtKB:P15923]
synonym: "TCF3" RELATED Gene-based [UniProtKB:P15923]
synonym: "hTCF3" EXACT PRO-short-label [PRO:DNx]
synonym: "BHLHB21" RELATED Gene-based [UniProtKB:P15923]
synonym: "TCF-3 (human)" BROAD [UniProtKB:P15923]
synonym: "transcription factor 3 (human)" EXACT [UniProtKB:P15923]
synonym: "kappa-E2-binding factor (human)" EXACT [UniProtKB:P15923]
synonym: "transcription factor ITF-1 (human)" EXACT [UniProtKB:P15923]
synonym: "immunoglobulin transcription factor 1 (human)" EXACT [UniProtKB:P15923]
synonym: "class B basic helix-loop-helix protein 21 (human)" EXACT [UniProtKB:P15923]
synonym: "immunoglobulin enhancer-binding factor E12/E47 (human)" EXACT [UniProtKB:P15923]
xref: Reactome:R-HSA-3209896 "PR:P15923 located_in GO:0005654"
xref: UniProtKB:P15923
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001943 ! transcription factor E2-alpha
relationship: has_gene_template HGNC:11633 ! TCF3 (human)

[Term]
id: PR:P15923-2
name: transcription factor E2-alpha isoform hE47 (human)
def: "A transcription factor E2-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15923-2." [PRO:DNx, UniProtKB:P15923]
comment: Category=organism-sequence.
synonym: "hTCF3/iso:hE47" EXACT PRO-short-label [PRO:DNx]
synonym: "transcription factor E2-alpha isoform PAN-1 (human)" EXACT [UniProtKB:P15923]
xref: UniProtKB:P15923-2
is_a: PR:P15923 ! transcription factor E2-alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P15923-3
name: transcription factor E2-alpha isoform h3 (human)
def: "A transcription factor E2-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15923-3." [PRO:DNx, UniProtKB:P15923]
comment: Category=organism-sequence.
synonym: "hTCF3/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P15923-3
is_a: PR:P15923 ! transcription factor E2-alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P15923-1
name: transcription factor E2-alpha isoform hE12 (human)
def: "A transcription factor E2-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15923-1." [PRO:DNx, UniProtKB:P15923]
comment: Category=organism-sequence.
synonym: "hTCF3/iso:hE12" EXACT PRO-short-label [PRO:DNx]
synonym: "transcription factor E2-alpha isoform PAN-2 (human)" EXACT [UniProtKB:P15923]
xref: UniProtKB:P15923-1
is_a: PR:P15923 ! transcription factor E2-alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens