[Term]
id: PR:000001868
name: interleukin-6 receptor subunit beta
def: "A protein that is a translation product of the human IL6ST gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "CD130" EXACT []
synonym: "IL6ST" EXACT PRO-short-label [PRO:DNx]
synonym: "gp130" EXACT []
synonym: "CDw130" EXACT []
synonym: "IL-6RB" EXACT []
synonym: "IL-6R-beta" EXACT []
synonym: "IL-6R subunit beta" EXACT []
synonym: "membrane glycoprotein 130" EXACT []
synonym: "IL-6 receptor subunit beta" EXACT []
synonym: "interleukin-6 signal transducer" EXACT []
synonym: "oncostatin-M receptor subunit alpha" EXACT []
xref: IUPHARobj:2317
is_a: PR:000000001 ! protein

[Term]
id: PR:P40189
name: interleukin-6 receptor subunit beta (human)
def: "An interleukin-6 receptor subunit beta that is encoded in the genome of human." [PRO:WCB, UniProtKB:P40189]
comment: Category=organism-gene.
synonym: "IL6ST" RELATED Gene-based [UniProtKB:P40189]
synonym: "hIL6ST" EXACT PRO-short-label [PRO:DNx]
synonym: "CD130 (human)" EXACT [UniProtKB:P40189]
synonym: "gp130 (human)" EXACT [UniProtKB:P40189]
synonym: "CDw130 (human)" EXACT [UniProtKB:P40189]
synonym: "IL-6RB (human)" EXACT [UniProtKB:P40189]
synonym: "IL-6R-beta (human)" EXACT [UniProtKB:P40189]
synonym: "IL-6R subunit beta (human)" EXACT [UniProtKB:P40189]
synonym: "membrane glycoprotein 130 (human)" EXACT [UniProtKB:P40189]
synonym: "IL-6 receptor subunit beta (human)" EXACT [UniProtKB:P40189]
synonym: "interleukin-6 signal transducer (human)" EXACT [UniProtKB:P40189]
synonym: "oncostatin-M receptor subunit alpha (human)" EXACT [UniProtKB:P40189]
xref: UniProtKB:P40189
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001868 ! interleukin-6 receptor subunit beta
relationship: has_gene_template HGNC:6021 ! IL6ST (human)

[Term]
id: PR:000048030
name: interleukin-6 receptor subunit beta, signal peptide removed form (human)
def: "An interleukin-6 receptor subunit beta (human) that has had the signal peptide removed. UniProtKB:P40189, 23-918." [PRO:DNx, Reactome:R-HSA-448453]
comment: Category=organism-modification.
synonym: "PRO_0000010899" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hIL6ST/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P40189, 23-918" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-448453 "PR:000048030 located_in GO:0005886"
intersection_of: PR:P40189 ! interleukin-6 receptor subunit beta (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P40189-1
name: interleukin-6 receptor subunit beta isoform h1 (human)
def: "An interleukin-6 receptor subunit beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P40189-1." [PRO:DNx, UniProtKB:P40189]
comment: Category=organism-sequence.
synonym: "hIL6ST/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P40189-1
is_a: PR:P40189 ! interleukin-6 receptor subunit beta (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000056496
name: interleukin-6 receptor subunit beta N-glycosylated 1 (human)
def: "An interleukin-6 receptor subunit beta (human) that has been N-glycosylated at the residue equivalent to Asn-379 of the amino acid sequence represented by UniProtKB:P40189-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P40189-1, Asn-379, MOD:00160~GNO:G58001LT." [GlyGen:P40189-1, PMID:23345538, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hIL6ST/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P40189-1, Asn-379, MOD:00160~GNO:G58001LT" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P40189 ! interleukin-6 receptor subunit beta (human)
relationship: has_part GNO:G58001LT ! G58001LT
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000056497
name: interleukin-6 receptor subunit beta N-glycosylated 2 (human)
def: "An interleukin-6 receptor subunit beta (human) that has been N-glycosylated at the residue equivalent to Asn-390 of the amino acid sequence represented by UniProtKB:P40189-1, in which the glycan composition is represented by GlyTouCan:G72787SB. Example: UniProtKB:P40189-1, Asn-390, MOD:00160~GNO:G72787SB." [GlyGen:P40189-1, PMID:23345538, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hIL6ST/NGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P40189-1, Asn-390, MOD:00160~GNO:G72787SB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P40189 ! interleukin-6 receptor subunit beta (human)
relationship: has_part GNO:G72787SB ! G72787SB
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000056499
name: interleukin-6 receptor subunit beta N-glycosylated 4 (human)
def: "An interleukin-6 receptor subunit beta (human) that has been N-glycosylated at the residue equivalent to Asn-818 of the amino acid sequence represented by UniProtKB:P40189-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P40189-1, Asn-818, MOD:00160~GNO:G58001LT." [GlyGen:P40189-1, PMID:23345538, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hIL6ST/NGlyco:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P40189-1, Asn-818, MOD:00160~GNO:G58001LT" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P40189 ! interleukin-6 receptor subunit beta (human)
relationship: has_part GNO:G58001LT ! G58001LT
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P40189-2
name: interleukin-6 receptor subunit beta isoform h2 (human)
def: "An interleukin-6 receptor subunit beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P40189-2." [PRO:DNx, UniProtKB:P40189]
comment: Category=organism-sequence.
synonym: "hIL6ST/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "interleukin-6 receptor subunit beta isoform GP130-RAPS (human)" EXACT [UniProtKB:P40189]
xref: UniProtKB:P40189-2
is_a: PR:P40189 ! interleukin-6 receptor subunit beta (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P40189-3
name: interleukin-6 receptor subunit beta isoform h3 (human)
def: "An interleukin-6 receptor subunit beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P40189-3." [PRO:DNx, UniProtKB:P40189]
comment: Category=organism-sequence.
synonym: "hIL6ST/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P40189-3
is_a: PR:P40189 ! interleukin-6 receptor subunit beta (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens