[Term]
id: PR:Q9WVS0
name: inducible T-cell costimulator (mouse)
def: "An inducible T-cell costimulator that is encoded in the genome of mouse." [OMA:Q9WVS0, PRO:DNx]
comment: Category=organism-gene.
synonym: "Icos" RELATED Gene-based [UniProtKB:Q9WVS0]
synonym: "Ailim" RELATED Gene-based [UniProtKB:Q9WVS0]
synonym: "mICOS" EXACT PRO-short-label [PRO:DNx]
synonym: "CCLP (mouse)" EXACT [UniProtKB:Q9WVS0]
synonym: "CD278 (mouse)" EXACT [UniProtKB:Q9WVS0]
synonym: "CRP-1 (mouse)" RELATED [UniProtKB:Q9WVS0]
synonym: "CD28-related protein 1 (mouse)" EXACT [UniProtKB:Q9WVS0]
synonym: "CD28 and CTLA-4-like protein (mouse)" EXACT [UniProtKB:Q9WVS0]
synonym: "activation-inducible lymphocyte immunomediatory molecule (mouse)" EXACT [UniProtKB:Q9WVS0]
xref: UniProtKB:Q9WVS0
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001860 ! inducible T-cell costimulator
relationship: has_gene_template MGI:1858745 ! Icos (mouse)

[Term]
id: PR:Q9WVS0-1
name: inducible T-cell costimulator isoform 1 (mouse)
def: "An inducible T-cell costimulator isoform 1 that is encoded in the genome of mouse." [PRO:CNx]
comment: Category=organism-sequence.
synonym: "mICOS/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9WVS0-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000026924 ! inducible T-cell costimulator isoform 1

[Term]
id: PR:Q9R1T7-2
name: inducible T-cell costimulator isoform r2 (rat)
def: "An inducible T-cell costimulator (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9R1T7-2." [PRO:DNx, UniProtKB:Q9R1T7]
comment: Category=organism-sequence.
synonym: "rICOS/iso:r2" EXACT PRO-short-label [PRO:DNx]
synonym: "inducible T-cell costimulator isoform AILIM-2 (rat)" EXACT [UniProtKB:Q9R1T7]
xref: UniProtKB:Q9R1T7-2
is_a: PR:Q9R1T7 ! inducible T-cell costimulator (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:Q9Y6W8-2
name: inducible T-cell costimulator isoform h2 (human)
def: "An inducible T-cell costimulator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6W8-2." [PRO:DNx, UniProtKB:Q9Y6W8]
comment: Category=organism-sequence.
synonym: "hICOS/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Y6W8-2
is_a: PR:Q9Y6W8 ! inducible T-cell costimulator (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9R1T7-1
name: inducible T-cell costimulator isoform r1 (rat)
def: "An inducible T-cell costimulator (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9R1T7-1." [PRO:DNx, UniProtKB:Q9R1T7]
comment: Category=organism-sequence.
synonym: "rICOS/iso:r1" EXACT PRO-short-label [PRO:DNx]
synonym: "inducible T-cell costimulator isoform AILIM-1 (rat)" EXACT [UniProtKB:Q9R1T7]
xref: UniProtKB:Q9R1T7-1
is_a: PR:Q9R1T7 ! inducible T-cell costimulator (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:000001860
name: inducible T-cell costimulator
def: "A protein that is a translation product of the human ICOS gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene. Requested by=CL.
synonym: "CCLP" EXACT []
synonym: "ICOS" EXACT PRO-short-label [PRO:DNx]
synonym: "AILIM" RELATED Gene-based []
synonym: "CD278" EXACT []
synonym: "CRP-1" RELATED []
synonym: "CD28-related protein 1" EXACT []
synonym: "CD28 and CTLA-4-like protein" EXACT []
synonym: "activation-inducible lymphocyte immunomediatory molecule" EXACT []
xref: IUPHARobj:2939
is_a: PR:000000001 ! protein

[Term]
id: PR:Q9Y6W8-1
name: inducible T-cell costimulator isoform 1 (human)
def: "An inducible T-cell costimulator isoform 1 that is encoded in the genome of human." [PRO:CNx]
comment: Category=organism-sequence.
synonym: "hICOS/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Y6W8-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026924 ! inducible T-cell costimulator isoform 1

[Term]
id: PR:Q9Y6W8
name: inducible T-cell costimulator (human)
def: "An inducible T-cell costimulator that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q9Y6W8]
comment: Category=organism-gene.
synonym: "ICOS" RELATED Gene-based [UniProtKB:Q9Y6W8]
synonym: "AILIM" RELATED Gene-based [UniProtKB:Q9Y6W8]
synonym: "hICOS" EXACT PRO-short-label [PRO:DNx]
synonym: "CD278 (human)" EXACT [UniProtKB:Q9Y6W8]
synonym: "activation-inducible lymphocyte immunomediatory molecule (human)" EXACT [UniProtKB:Q9Y6W8]
xref: UniProtKB:Q9Y6W8
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001860 ! inducible T-cell costimulator
relationship: has_gene_template HGNC:5351 ! ICOS (human)

[Term]
id: PR:Q9R1T7
name: inducible T-cell costimulator (rat)
def: "An inducible T-cell costimulator that is encoded in the genome of rat." [OMA:Q9R1T7, PANTHER:PTHR20904:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "Icos" RELATED Gene-based [UniProtKB:Q9R1T7]
synonym: "Ailim" RELATED Gene-based [UniProtKB:Q9R1T7]
synonym: "rICOS" EXACT PRO-short-label [PRO:DNx]
synonym: "CD278 (rat)" EXACT [UniProtKB:Q9R1T7]
synonym: "activation-inducible lymphocyte immunomediatory molecule (rat)" EXACT [UniProtKB:Q9R1T7]
xref: UniProtKB:Q9R1T7
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000001860 ! inducible T-cell costimulator
relationship: has_gene_template RGD:620123 ! Icos (rat)

[Term]
id: PR:000026927
name: inducible T-cell costimulator isoform 1, signal peptide removed form (human)
def: "An inducible T-cell costimulator isoform 1, signal peptide removed form in human. UniProtKB:Q9Y6W8-1, 21-199." [PRO:CNx, Reactome:R-HSA-198144]
comment: Category=organism-modification.
synonym: "PRO_0000014806" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hICOS/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Y6W8-1, 21-199" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-198144 "PR:000026927 located_in GO:0005886"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026926 ! inducible T-cell costimulator isoform 1, signal peptide removed form

[Term]
id: PR:000026926
name: inducible T-cell costimulator isoform 1, signal peptide removed form
def: "An inducible T-cell costimulator isoform 1 that has had the signal peptide removed. Example: UniProtKB:Q9Y6W8-1, 21-199." [PRO:CNx]
comment: Category=modification.
synonym: "ICOS/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000026924 ! inducible T-cell costimulator isoform 1
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000026924
name: inducible T-cell costimulator isoform 1
def: "An inducible T-cell costimulator that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6W8-1 or a 1:1 ortholog thereof." [PRO:CNx]
comment: Category=sequence.
synonym: "ICOS/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001860 ! inducible T-cell costimulator