[Term]
id: PR:000001822
name: MHC class II histocompatibility antigen gamma chain
def: "A protein that is a translation product of the human CD74 gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "Ii" RELATED Gene-based []
synonym: "p33" BROAD [PRO:DNx]
synonym: "CD74" EXACT PRO-short-label [PRO:DNx]
synonym: "DHLAG" RELATED Gene-based []
synonym: "MHCcIIgamma" EXACT [PRO:DAN]
synonym: "Ia antigen-associated invariant chain" EXACT []
synonym: "MHC class II-associated invariant chain" EXACT []
synonym: "HLA-DR antigens-associated invariant chain" NARROW [PRO:DAN]
xref: IUPHARobj:2840
xref: PIRSF:PIRSF001992
is_a: PR:000000001 ! protein

[Term]
id: PR:P04233-5
name: HLA class II histocompatibility antigen gamma chain isoform hp33 (human)
def: "An HLA class II histocompatibility antigen gamma chain (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04233-5." [PRO:DNx, UniProtKB:P04233]
comment: Category=organism-sequence.
synonym: "hCD74/iso:hp33" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P04233-5
is_a: PR:P04233 ! HLA class II histocompatibility antigen gamma chain (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000053340
name: HLA class II histocompatibility antigen gamma chain O-glycosylated 4 (human)
def: "An HLA class II histocompatibility antigen gamma chain (human) that has been O-glycosylated at the residue equivalent to Thr-287 of the amino acid sequence represented by UniProtKB:P04233-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P04233-1, Thr-287, MOD:00005~GNO:G43417UB." [GlyGen:P04233-1, PMID:22171320, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hCD74/OGlyco:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04233-1, Thr-287, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P04233 ! HLA class II histocompatibility antigen gamma chain (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04233-1
name: HLA class II histocompatibility antigen gamma chain isoform hp45 (human)
def: "An HLA class II histocompatibility antigen gamma chain (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04233-1." [PRO:DNx, UniProtKB:P04233]
comment: Category=organism-sequence.
synonym: "hCD74/iso:hp45" EXACT PRO-short-label [PRO:DNx]
synonym: "HLA class II histocompatibility antigen gamma chain isoform Long (human)" EXACT [UniProtKB:P04233]
xref: UniProtKB:P04233-1
is_a: PR:P04233 ! HLA class II histocompatibility antigen gamma chain (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04233-2
name: HLA class II histocompatibility antigen gamma chain isoform hp35 (human)
def: "An HLA class II histocompatibility antigen gamma chain (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04233-2." [PRO:DNx, UniProtKB:P04233]
comment: Category=organism-sequence.
synonym: "hCD74/iso:hp35" EXACT PRO-short-label [PRO:DNx]
synonym: "HLA class II histocompatibility antigen gamma chain isoform Short (human)" EXACT [UniProtKB:P04233]
xref: UniProtKB:P04233-2
is_a: PR:P04233 ! HLA class II histocompatibility antigen gamma chain (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04233-3
name: HLA class II histocompatibility antigen gamma chain isoform h3 (human)
def: "An HLA class II histocompatibility antigen gamma chain (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04233-3." [PRO:DNx, UniProtKB:P04233]
comment: Category=organism-sequence.
synonym: "hCD74/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P04233-3
is_a: PR:P04233 ! HLA class II histocompatibility antigen gamma chain (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04233-4
name: HLA class II histocompatibility antigen gamma chain isoform hp41 (human)
def: "An HLA class II histocompatibility antigen gamma chain (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04233-4." [PRO:DNx, UniProtKB:P04233]
comment: Category=organism-sequence.
synonym: "hCD74/iso:hp41" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P04233-4
is_a: PR:P04233 ! HLA class II histocompatibility antigen gamma chain (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000053337
name: HLA class II histocompatibility antigen gamma chain O-glycosylated 1 (human)
def: "An HLA class II histocompatibility antigen gamma chain (human) that has been O-glycosylated at the residue equivalent to Ser-281 of the amino acid sequence represented by UniProtKB:P04233-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P04233-1, Ser-281, MOD:00002~GNO:G43417UB." [GlyGen:P04233-1, PMID:22171320, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hCD74/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04233-1, Ser-281, MOD:00002~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P04233 ! HLA class II histocompatibility antigen gamma chain (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000053338
name: HLA class II histocompatibility antigen gamma chain O-glycosylated 2 (human)
def: "An HLA class II histocompatibility antigen gamma chain (human) that has been O-glycosylated at the residue equivalent to Ser-282 of the amino acid sequence represented by UniProtKB:P04233-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P04233-1, Ser-282, MOD:00002~GNO:G43417UB." [GlyGen:P04233-1, PMID:22171320, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hCD74/OGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04233-1, Ser-282, MOD:00002~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P04233 ! HLA class II histocompatibility antigen gamma chain (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000053339
name: HLA class II histocompatibility antigen gamma chain O-glycosylated 3 (human)
def: "An HLA class II histocompatibility antigen gamma chain (human) that has been O-glycosylated at the residue equivalent to Thr-203 of the amino acid sequence represented by UniProtKB:P04233-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P04233-1, Thr-203, MOD:00005~GNO:G43417UB." [GlyGen:P04233-1, PMID:22171320, PMID:23234360, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hCD74/OGlyco:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04233-1, Thr-203, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P04233 ! HLA class II histocompatibility antigen gamma chain (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04233
name: HLA class II histocompatibility antigen gamma chain (human)
def: "An MHC class II histocompatibility antigen gamma chain that is encoded in the genome of human." [PRO:WCB, UniProtKB:P04233]
comment: Category=organism-gene.
synonym: "CD74" RELATED Gene-based [UniProtKB:P04233]
synonym: "DHLAG" RELATED Gene-based [UniProtKB:P04233]
synonym: "hCD74" EXACT PRO-short-label [PRO:DNx]
synonym: "Ii (human)" EXACT [UniProtKB:P04233]
synonym: "p33 (human)" BROAD [UniProtKB:P04233]
synonym: "HLA-DR antigens-associated invariant chain" EXACT [UniProtKB:P04233]
synonym: "Ia antigen-associated invariant chain (human)" EXACT [UniProtKB:P04233]
xref: Reactome:R-HSA-1181241 "PR:P04233 located_in GO:0071556"
xref: Reactome:R-HSA-2130320 "PR:P04233 located_in GO:0005765"
xref: Reactome:R-HSA-2130456 "PR:P04233 located_in GO:0012507"
xref: Reactome:R-HSA-2130460 "PR:P04233 located_in GO:0030666"
xref: Reactome:R-HSA-2130493 "PR:P04233 located_in GO:0032588"
xref: Reactome:R-HSA-2130522 "PR:P04233 located_in GO:0030669"
xref: Reactome:R-HSA-2130624 "PR:P04233 located_in GO:0030658"
xref: Reactome:R-HSA-2130666 "PR:P04233 located_in GO:0005886"
xref: Reactome:R-HSA-2214388 "PR:P04233 located_in GO:0000139"
xref: UniProtKB:P04233
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001822 ! MHC class II histocompatibility antigen gamma chain
relationship: has_gene_template HGNC:1697 ! CD74 (human)