[Term]
id: PR:Q84M95-1
name: probable serine/threonine-protein kinase PBL28 isoform 1 (Arabidopsis thaliana)
def: "A probable serine/threonine-protein kinase PBL28 (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q84M95-1." [PRO:DNx, UniProtKB:Q84M95]
comment: Category=organism-sequence.
synonym: "At-IKBKB/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q84M95-1
is_a: PR:Q84M95 ! probable serine/threonine-protein kinase PBL28 (Arabidopsis thaliana)
relationship: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana

[Term]
id: PR:O88351
name: inhibitor of nuclear factor kappa-B kinase subunit beta (mouse)
def: "An inhibitor of nuclear factor kappa-B kinase subunit beta that is encoded in the genome of mouse." [OMA:O88351, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ikkb" RELATED Gene-based [UniProtKB:O88351]
synonym: "Ikbkb" RELATED Gene-based [UniProtKB:O88351]
synonym: "mIKBKB" EXACT PRO-short-label [PRO:DNx]
synonym: "IKK2 (mouse)" EXACT [UniProtKB:O88351]
synonym: "IKK-B (mouse)" EXACT [UniProtKB:O88351]
synonym: "IkBKB (mouse)" EXACT [UniProtKB:O88351]
synonym: "NFKBIKB (mouse)" EXACT [UniProtKB:O88351]
synonym: "IKK-beta (mouse)" EXACT [UniProtKB:O88351]
synonym: "I-kappa-B kinase 2 (mouse)" EXACT [UniProtKB:O88351]
synonym: "I-kappa-B-kinase beta (mouse)" EXACT [UniProtKB:O88351]
synonym: "serine/threonine protein kinase IKBKB (mouse)" EXACT [UniProtKB:O88351]
synonym: "nuclear factor NF-kappa-B inhibitor kinase beta (mouse)" EXACT [UniProtKB:O88351]
xref: UniProtKB:O88351
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001776 ! inhibitor of nuclear factor kappa-B kinase subunit beta
relationship: has_gene_template MGI:1338071 ! Ikbkb (mouse)

[Term]
id: PR:000035831
name: inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 (human)
def: "An inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 in human. UniProtKB:O14920, Ser-177/Ser-181, MOD:00046." [PRO:DNx, UniProtKB:O14920]
comment: Category=organism-modification. Kinase=("p-T184,187-TAK1"; PR:000035736).
synonym: "hIKBKB/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "phospho-IKK2 (human)" EXACT [Reactome:R-HSA-202506]
synonym: "p-S177,S181-IKK beta (human)" EXACT [Reactome:R-HSA-202506]
synonym: "UniProtKB:O14920, Ser-177/Ser-181, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-202506 "PR:000035831 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000035830 ! inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000036115
name: inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 (mouse)
def: "An inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 in mouse. Phosphorylation is necessary for activation, and occurs on two Ser residues in the activation loop. UniProtKB:O88351, Ser-177/Ser-181, MOD:00046." [PMID:16751795, PMID:18202307, PRO:CNA, PRO:DAN]
comment: Category=organism-modification.
synonym: "mIKBKB/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "p-S177,S181-IKK beta (mouse)" EXACT []
synonym: "UniProtKB:O88351, Ser-177/Ser-181, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000035830 ! inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:O14920
name: inhibitor of nuclear factor kappa-B kinase subunit beta (human)
def: "An inhibitor of nuclear factor kappa-B kinase subunit beta that is encoded in the genome of human." [PRO:DNx, UniProtKB:O14920]
comment: Category=organism-gene.
synonym: "IKKB" RELATED Gene-based [UniProtKB:O14920]
synonym: "IKBKB" RELATED Gene-based [UniProtKB:O14920]
synonym: "hIKBKB" EXACT PRO-short-label [PRO:DNx]
synonym: "IKK2 (human)" EXACT [UniProtKB:O14920]
synonym: "IKK-B (human)" EXACT [UniProtKB:O14920]
synonym: "IkBKB (human)" EXACT [UniProtKB:O14920]
synonym: "NFKBIKB (human)" EXACT [UniProtKB:O14920]
synonym: "IKK-beta (human)" EXACT [UniProtKB:O14920]
synonym: "I-kappa-B kinase 2 (human)" EXACT [UniProtKB:O14920]
synonym: "I-kappa-B-kinase beta (human)" EXACT [UniProtKB:O14920]
synonym: "serine/threonine protein kinase IKBKB (human)" EXACT [UniProtKB:O14920]
synonym: "nuclear factor NF-kappa-B inhibitor kinase beta (human)" EXACT [UniProtKB:O14920]
xref: Reactome:R-HSA-168114 "PR:O14920 located_in GO:0005829"
xref: Reactome:R-HSA-1168584 "PR:O14920 located_in GO:0005886"
xref: DTO:03100182
xref: UniProtKB:O14920
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001776 ! inhibitor of nuclear factor kappa-B kinase subunit beta
relationship: has_gene_template HGNC:5960 ! IKBKB (human)

[Term]
id: PR:000035830
name: inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1
def: "An inhibitor of nuclear factor kappa-B kinase subunit beta that has been phosphorylated at two Ser residues within the activation loop in the protein kinase domain. Example: UniProtKB:O14920, Ser-177/Ser-181, MOD:00046." [PRO:DNx, Reactome:R-HSA-202506]
comment: Category=modification.
synonym: "IKBKB/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001776 ! inhibitor of nuclear factor kappa-B kinase subunit beta
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:O14920-3
name: inhibitor of nuclear factor kappa-B kinase subunit beta isoform h3 (human)
def: "An inhibitor of nuclear factor kappa-B kinase subunit beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14920-3." [PRO:DNx, UniProtKB:O14920]
comment: Category=organism-sequence.
synonym: "hIKBKB/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O14920-3
is_a: PR:O14920 ! inhibitor of nuclear factor kappa-B kinase subunit beta (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O14920-2
name: inhibitor of nuclear factor kappa-B kinase subunit beta isoform h2 (human)
def: "An inhibitor of nuclear factor kappa-B kinase subunit beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14920-2." [PRO:DNx, UniProtKB:O14920]
comment: Category=organism-sequence.
synonym: "hIKBKB/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O14920-2
is_a: PR:O14920 ! inhibitor of nuclear factor kappa-B kinase subunit beta (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O14920-1
name: inhibitor of nuclear factor kappa-B kinase subunit beta isoform h1 (human)
def: "An inhibitor of nuclear factor kappa-B kinase subunit beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14920-1." [PRO:DNx, UniProtKB:O14920]
comment: Category=organism-sequence.
synonym: "hIKBKB/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O14920-1
is_a: PR:O14920 ! inhibitor of nuclear factor kappa-B kinase subunit beta (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9QY78
name: inhibitor of nuclear factor kappa-B kinase subunit beta (rat)
def: "An inhibitor of nuclear factor kappa-B kinase subunit beta that is encoded in the genome of rat." [PANTHER:PTHR22969:SF7, PRO:DAN]
comment: Category=organism-gene.
synonym: "Ikkb" RELATED Gene-based [UniProtKB:Q9QY78]
synonym: "Ikbkb" RELATED Gene-based [UniProtKB:Q9QY78]
synonym: "rIKBKB" EXACT PRO-short-label [PRO:DNx]
synonym: "IKK2 (rat)" EXACT [UniProtKB:Q9QY78]
synonym: "IKK-B (rat)" EXACT [UniProtKB:Q9QY78]
synonym: "IkBKB (rat)" EXACT [UniProtKB:Q9QY78]
synonym: "NFKBIKB (rat)" EXACT [UniProtKB:Q9QY78]
synonym: "IKK-beta (rat)" EXACT [UniProtKB:Q9QY78]
synonym: "I-kappa-B kinase 2 (rat)" EXACT [UniProtKB:Q9QY78]
synonym: "I-kappa-B-kinase beta (rat)" EXACT [UniProtKB:Q9QY78]
synonym: "serine/threonine protein kinase IKBKB (rat)" EXACT [UniProtKB:Q9QY78]
synonym: "nuclear factor NF-kappa-B inhibitor kinase beta (rat)" EXACT [UniProtKB:Q9QY78]
xref: UniProtKB:Q9QY78
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000001776 ! inhibitor of nuclear factor kappa-B kinase subunit beta
relationship: has_gene_template RGD:621375 ! Ikbkb (rat)

[Term]
id: PR:Q84M95
name: probable serine/threonine-protein kinase PBL28 (Arabidopsis thaliana)
def: "An inhibitor of nuclear factor kappa-B kinase subunit beta that is encoded in the genome of Arabidopsis thaliana." [PRO:CNA]
comment: Category=organism-gene.
synonym: "PBL28" RELATED Gene-based [UniProtKB:Q84M95]
synonym: "At-IKBKB" EXACT PRO-short-label [PRO:DNx]
synonym: "At1g24030" RELATED Gene-based [UniProtKB:Q84M95]
synonym: "T23E23.18" RELATED Gene-based [UniProtKB:Q84M95]
synonym: "PBS1-like protein 28 (Arabidopsis thaliana)" EXACT [UniProtKB:Q84M95]
xref: UniProtKB:Q84M95
intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana
intersection_of: PR:000001776 ! inhibitor of nuclear factor kappa-B kinase subunit beta
relationship: has_gene_template Araport:AT1G24030 ! PBL28 (Arabidopsis thaliana)

[Term]
id: PR:O14920-4
name: inhibitor of nuclear factor kappa-B kinase subunit beta isoform h4 (human)
def: "An inhibitor of nuclear factor kappa-B kinase subunit beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14920-4." [PRO:DNx, UniProtKB:O14920]
comment: Category=organism-sequence.
synonym: "hIKBKB/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O14920-4
is_a: PR:O14920 ! inhibitor of nuclear factor kappa-B kinase subunit beta (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q5ZI83
name: uncharacterized protein, RCJMB04_29g15 translation product (chicken)
def: "An inhibitor of nuclear factor kappa-B kinase subunit beta that is encoded in the genome of chicken." [PANTHER:PTHR22969:SF7, PRO:DNx]
comment: Category=organism-gene.
synonym: "chick-IKBKB" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q5ZI83
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000001776 ! inhibitor of nuclear factor kappa-B kinase subunit beta
relationship: has_gene_template CGNC:2733 ! IKBKB (chicken)

[Term]
id: PR:000001776
name: inhibitor of nuclear factor kappa-B kinase subunit beta
def: "An inhibitor of nuclear factor kappa-B kinase complex alpha/beta subunits that is a translation product of the human IKBKB gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "IKK2" EXACT []
synonym: "IKKB" RELATED Gene-based []
synonym: "IKBKB" EXACT PRO-short-label [PRO:DNx]
synonym: "IKK-B" EXACT []
synonym: "IkBKB" EXACT []
synonym: "NFKBIKB" EXACT []
synonym: "IKK-beta" EXACT []
synonym: "I-kappa-B kinase 2" EXACT []
synonym: "I-kappa-B-kinase beta" EXACT []
synonym: "serine/threonine protein kinase IKBKB" EXACT []
synonym: "nuclear factor NF-kappa-B inhibitor kinase beta" EXACT []
xref: IUPHARobj:2039
is_a: PR:000001774 ! inhibitor of nuclear factor kappa-B kinase complex alpha/beta subunits