[Term]
id: PR:000001719
name: transient receptor potential cation channel TRPM8
def: "A transient receptor potential channel protein that is a translation product of the human TRPM8 gene or a 1:1 ortholog thereof. TRPM8 is a member of the subfamily M of the transient receptor potential cation channels (TRPs). In common with other TRPs, these proteins have amino- and carboxyl-terminal intracellular domains separated by a domain containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity.TRPM8 forms a nonselective cation channel that is activated by cold and by menthol and other substances that produce the sensation of coolness. These channels exhibit voltage-dependance and regulation by phosphatidylinositol-4,5-bisphosphate (PIP2)." [PMID:15852009, PRO:CNA]
comment: Category=gene.
synonym: "TRPM8" EXACT PRO-short-label [PRO:DNx]
synonym: "TRPP8" RELATED Gene-based []
synonym: "LTRPC6" RELATED Gene-based []
synonym: "LTrpC6" EXACT []
synonym: "Trp-p8" EXACT []
synonym: "LTrpC-6" EXACT []
synonym: "transient receptor potential p8" EXACT []
synonym: "long transient receptor potential channel 6" EXACT []
xref: IUPHARobj:500
xref: PIRSF:PIRSF038526
is_a: PR:000044657 ! transient receptor potential channel protein