[Term]
id: PR:Q8R4D5
name: transient receptor potential cation channel subfamily M member 8 (mouse)
def: "A transient receptor potential cation channel TRPM8 that is encoded in the genome of mouse." [OMA:Q8R4D5, PRO:DNx]
comment: Category=organism-gene.
synonym: "Trpm8" RELATED Gene-based [UniProtKB:Q8R4D5]
synonym: "Trpp8" RELATED Gene-based [UniProtKB:Q8R4D5]
synonym: "Ltrpc6" RELATED Gene-based [UniProtKB:Q8R4D5]
synonym: "mTRPM8" EXACT PRO-short-label [PRO:DNx]
synonym: "LTrpC6 (mouse)" EXACT [UniProtKB:Q8R4D5]
synonym: "Trp-p8 (mouse)" EXACT [UniProtKB:Q8R4D5]
synonym: "LTrpC-6 (mouse)" EXACT [UniProtKB:Q8R4D5]
synonym: "transient receptor potential p8 (mouse)" EXACT [UniProtKB:Q8R4D5]
synonym: "long transient receptor potential channel 6 (mouse)" EXACT [UniProtKB:Q8R4D5]
xref: UniProtKB:Q8R4D5
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001719 ! transient receptor potential cation channel TRPM8
relationship: has_gene_template MGI:2181435 ! Trpm8 (mouse)

[Term]
id: PR:000036607
name: transient receptor potential cation channel TRPM8 isoform 1 N-glycosylated 1 (mouse)
def: "A transient receptor potential cation channel TRPM8 isoform 1 N-glycosylated 1 in mouse. UniProtKB:Q8R4D5-1, Asn-934, MOD:00160." [PMID:17015441, PRO:HJD]
comment: Category=organism-modification.
synonym: "mTRPM8/iso:1/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8R4D5-1, Asn-934, MOD:00160" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001724 ! transient receptor potential cation channel TRPM8 isoform 1 N-glycosylated 1
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: PR:Q8R4D5-1
name: transient receptor potential cation channel subfamily M member 8 isoform 1 (mouse)
def: "A transient receptor potential cation channel TRPM8 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mTRPM8/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8R4D5-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001720 ! transient receptor potential cation channel TRPM8 isoform 1

[Term]
id: PR:000001719
name: transient receptor potential cation channel TRPM8
def: "A transient receptor potential channel protein that is a translation product of the human TRPM8 gene or a 1:1 ortholog thereof. TRPM8 is a member of the subfamily M of the transient receptor potential cation channels (TRPs). In common with other TRPs, these proteins have amino- and carboxyl-terminal intracellular domains separated by a domain containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity.TRPM8 forms a nonselective cation channel that is activated by cold and by menthol and other substances that produce the sensation of coolness. These channels exhibit voltage-dependance and regulation by phosphatidylinositol-4,5-bisphosphate (PIP2)." [PMID:15852009, PRO:CNA]
comment: Category=gene.
synonym: "TRPM8" EXACT PRO-short-label [PRO:DNx]
synonym: "TRPP8" RELATED Gene-based []
synonym: "LTRPC6" RELATED Gene-based []
synonym: "LTrpC6" EXACT []
synonym: "Trp-p8" EXACT []
synonym: "LTrpC-6" EXACT []
synonym: "transient receptor potential p8" EXACT []
synonym: "long transient receptor potential channel 6" EXACT []
xref: IUPHARobj:500
xref: PIRSF:PIRSF038526
is_a: PR:000044657 ! transient receptor potential channel protein