[Term]
id: PR:Q7Z2W7-4
name: transient receptor potential cation channel subfamily M member 8 isoform h4 (human)
def: "A transient receptor potential cation channel subfamily M member 8 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z2W7-4." [PRO:DNx, UniProtKB:Q7Z2W7]
comment: Category=organism-sequence.
synonym: "hTRPM8/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q7Z2W7-4
is_a: PR:Q7Z2W7 ! transient receptor potential cation channel subfamily M member 8 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q7Z2W7-2
name: transient receptor potential cation channel subfamily M member 8 isoform 2 (human)
def: "A transient receptor potential cation channel TRPM8 isoform 2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hTRPM8/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "transient receptor potential cation channel subfamily M member 8 isoform sM8-18 (human)" EXACT [UniProtKB:Q7Z2W7]
synonym: "transient receptor potential cation channel subfamily M member 8 isoform sTRPM8-18 (human)" EXACT [UniProtKB:Q7Z2W7]
xref: UniProtKB:Q7Z2W7-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001721 ! transient receptor potential cation channel TRPM8 isoform 2

[Term]
id: PR:Q7Z2W7-3
name: transient receptor potential cation channel subfamily M member 8 isoform 3 (human)
def: "A transient receptor potential cation channel TRPM8 isoform 3 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hTRPM8/iso:3" EXACT PRO-short-label [PRO:DNx]
synonym: "transient receptor potential cation channel subfamily M member 8 isoform sM8-6 (human)" EXACT [UniProtKB:Q7Z2W7]
synonym: "transient receptor potential cation channel subfamily M member 8 isoform sTRPM8-6 (human)" EXACT [UniProtKB:Q7Z2W7]
xref: UniProtKB:Q7Z2W7-3
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001722 ! transient receptor potential cation channel TRPM8 isoform 3

[Term]
id: PR:000001719
name: transient receptor potential cation channel TRPM8
def: "A transient receptor potential channel protein that is a translation product of the human TRPM8 gene or a 1:1 ortholog thereof. TRPM8 is a member of the subfamily M of the transient receptor potential cation channels (TRPs). In common with other TRPs, these proteins have amino- and carboxyl-terminal intracellular domains separated by a domain containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity.TRPM8 forms a nonselective cation channel that is activated by cold and by menthol and other substances that produce the sensation of coolness. These channels exhibit voltage-dependance and regulation by phosphatidylinositol-4,5-bisphosphate (PIP2)." [PMID:15852009, PRO:CNA]
comment: Category=gene.
synonym: "TRPM8" EXACT PRO-short-label [PRO:DNx]
synonym: "TRPP8" RELATED Gene-based []
synonym: "LTRPC6" RELATED Gene-based []
synonym: "LTrpC6" EXACT []
synonym: "Trp-p8" EXACT []
synonym: "LTrpC-6" EXACT []
synonym: "transient receptor potential p8" EXACT []
synonym: "long transient receptor potential channel 6" EXACT []
xref: IUPHARobj:500
xref: PIRSF:PIRSF038526
is_a: PR:000044657 ! transient receptor potential channel protein

[Term]
id: PR:Q7Z2W7-1
name: transient receptor potential cation channel subfamily M member 8 isoform 1 (human)
def: "A transient receptor potential cation channel TRPM8 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hTRPM8/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q7Z2W7-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001720 ! transient receptor potential cation channel TRPM8 isoform 1

[Term]
id: PR:Q7Z2W7
name: transient receptor potential cation channel subfamily M member 8 (human)
def: "A transient receptor potential cation channel TRPM8 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q7Z2W7]
comment: Category=organism-gene.
synonym: "TRPM8" RELATED Gene-based [UniProtKB:Q7Z2W7]
synonym: "TRPP8" RELATED Gene-based [UniProtKB:Q7Z2W7]
synonym: "LTRPC6" RELATED Gene-based [UniProtKB:Q7Z2W7]
synonym: "hTRPM8" EXACT PRO-short-label [PRO:DNx]
synonym: "Trp-p8 (human)" EXACT [UniProtKB:Q7Z2W7]
synonym: "LTrpC-6 (human)" EXACT [UniProtKB:Q7Z2W7]
synonym: "transient receptor potential p8 (human)" EXACT [UniProtKB:Q7Z2W7]
synonym: "long transient receptor potential channel 6 (human)" EXACT [UniProtKB:Q7Z2W7]
xref: UniProtKB:Q7Z2W7
xref: Reactome:R-HSA-2671931 "PR:Q7Z2W7 located_in GO:0005886"
xref: DTO:01100332
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001719 ! transient receptor potential cation channel TRPM8
relationship: has_gene_template HGNC:17961 ! TRPM8 (human)