[Term]
id: PR:P21453-1
name: sphingosine 1-phosphate receptor 1 isoform 1 (human)
def: "A sphingosine 1-phosphate receptor 1 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hS1PR1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P21453-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039053 ! sphingosine 1-phosphate receptor 1 isoform 1

[Term]
id: PR:000001706
name: sphingosine 1-phosphate receptor 1
def: "A lysophospholipid (S1P) receptor that is a translation product of the human S1PR1 gene or a 1:1 ortholog thereof. The receptor is specifically expressed in endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin." [PRO:WCB, UniProtKB:P21453]
comment: Category=gene.
synonym: "EDG1" RELATED Gene-based []
synonym: "Lpb1" RELATED Gene-based []
synonym: "S1P1" EXACT []
synonym: "CD363" EXACT [ImmPort:DSD]
synonym: "S1PR1" EXACT PRO-short-label [PRO:DNx]
synonym: "CHEDG1" RELATED Gene-based []
synonym: "S1P receptor 1" EXACT []
synonym: "S1P receptor Edg-1" EXACT []
synonym: "lysophospholipid receptor B1" EXACT []
synonym: "sphingosine 1-phosphate receptor Edg-1" EXACT []
synonym: "endothelial differentiation G-protein coupled receptor 1" EXACT []
xref: IUPHARobj:275
is_a: PR:000001673 ! lysophospholipid (S1P) receptor

[Term]
id: PR:P21453
name: sphingosine 1-phosphate receptor 1 (human)
def: "A sphingosine 1-phosphate receptor 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P21453]
comment: Category=organism-gene.
synonym: "EDG1" RELATED Gene-based [UniProtKB:P21453]
synonym: "S1PR1" RELATED Gene-based [UniProtKB:P21453]
synonym: "CHEDG1" RELATED Gene-based [UniProtKB:P21453]
synonym: "hS1PR1" EXACT PRO-short-label [PRO:DNx]
synonym: "S1P1 (human)" EXACT [UniProtKB:P21453]
synonym: "CD363 (human)" EXACT [UniProtKB:P21453]
synonym: "S1P receptor 1 (human)" EXACT [UniProtKB:P21453]
synonym: "S1P receptor Edg-1 (human)" EXACT [UniProtKB:P21453]
synonym: "sphingosine 1-phosphate receptor Edg-1 (human)" EXACT [UniProtKB:P21453]
synonym: "endothelial differentiation G-protein coupled receptor 1 (human)" EXACT [UniProtKB:P21453]
xref: Reactome:R-HSA-419340 "PR:P21453 located_in GO:0005886"
xref: DTO:02100763
xref: UniProtKB:P21453
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001706 ! sphingosine 1-phosphate receptor 1
relationship: has_gene_template HGNC:3165 ! S1PR1 (human)

[Term]
id: PR:000045710
name: sphingosine 1-phosphate receptor 1 phosphorylated 1 (human)
def: "A sphingosine 1-phosphate receptor 1 (human) that has been phosphorylated at Thr-236. UniProtKB:P21453, Thr-236, MOD:00047." [PMID:11583630, iPTMnet:P21453]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:11583630). Status=unreviewed.
synonym: "hS1PR1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P21453, Thr-236, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P21453 ! sphingosine 1-phosphate receptor 1 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens