[Term]
id: PR:000001663
name: proteinase-activated receptor 3
def: "A proteinase-activated receptor that is a translation product of the human F2RL2 gene or a 1:1 ortholog thereof. It is activated by thrombin, which cleaves the mature peptide, exposing a new amino end. The six new N-terminal residues act as a tethered ligand that induces activity." [PMID:15582715, PRO:WCB]
comment: Category=gene.
synonym: "PAR3" RELATED Gene-based []
synonym: "F2RL2" EXACT PRO-short-label [PRO:DNx]
synonym: "PAR-3" RELATED []
synonym: "thrombin receptor-like 2" EXACT []
synonym: "coagulation factor II receptor-like 2" EXACT []
xref: IUPHARobj:349
is_a: PR:000001550 ! proteinase-activated receptor

[Term]
id: PR:000047350
name: proteinase-activated receptor 3, signal peptide removed form (human)
def: "A proteinase-activated receptor 3 (human) that has had the signal peptide removed. UniProtKB:O00254, 22-374." [PRO:DNx, Reactome:R-HSA-61313]
comment: Category=organism-modification.
synonym: "hF2RL2/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O00254, 22-374" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-61313 "PR:000047350 located_in GO:0005886"
intersection_of: PR:O00254 ! proteinase-activated receptor 3 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O00254-1
name: proteinase-activated receptor 3 isoform h1 (human)
def: "A proteinase-activated receptor 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00254-1." [PRO:DNx, UniProtKB:O00254]
comment: Category=organism-sequence.
synonym: "hF2RL2/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O00254-1
is_a: PR:O00254 ! proteinase-activated receptor 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O00254-2
name: proteinase-activated receptor 3 isoform h2 (human)
def: "A proteinase-activated receptor 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00254-2." [PRO:DNx, UniProtKB:O00254]
comment: Category=organism-sequence.
synonym: "hF2RL2/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O00254-2
is_a: PR:O00254 ! proteinase-activated receptor 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O00254
name: proteinase-activated receptor 3 (human)
def: "A proteinase-activated receptor 3 that is encoded in the genome of human." [PRO:WCB, UniProtKB:O00254]
comment: Category=organism-gene.
synonym: "PAR3" RELATED Gene-based [UniProtKB:O00254]
synonym: "F2RL2" RELATED Gene-based [UniProtKB:O00254]
synonym: "hF2RL2" EXACT PRO-short-label [PRO:DNx]
synonym: "PAR-3 (human)" BROAD [UniProtKB:O00254]
synonym: "thrombin receptor-like 2 (human)" EXACT [UniProtKB:O00254]
synonym: "coagulation factor II receptor-like 2 (human)" EXACT [UniProtKB:O00254]
xref: DTO:02100739
xref: UniProtKB:O00254
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001663 ! proteinase-activated receptor 3
relationship: has_gene_template HGNC:3539 ! F2RL2 (human)