[Term]
id: PR:000001661
name: proteinase-activated receptor 1
def: "A proteinase-activated receptor that is a translation product of the human F2R gene or a 1:1 ortholog thereof. It is activated by thrombin, which cleaves the mature peptide, exposing a new amino end. The new N-terminal residues act as a tethered ligand that induces activity." [PMID:1672265, PRO:WCB]
comment: Category=gene.
synonym: "TR" RELATED Gene-based []
synonym: "F2R" EXACT PRO-short-label [PRO:DNx]
synonym: "CF2R" RELATED Gene-based []
synonym: "PAR1" RELATED Gene-based []
synonym: "PAR-1" EXACT []
synonym: "thrombin receptor" EXACT []
synonym: "coagulation factor II receptor" EXACT []
xref: IUPHARobj:347
is_a: PR:000001550 ! proteinase-activated receptor