[Term]
id: PR:000001565
name: H4 histamine receptor
def: "A histamine receptor that is a translation product of the human HRH4 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor is expressed primarily in the bone marrow and eosinophils but also in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node." [PRO:WCB, UniProtKB:Q9H3N8]
comment: Category=gene.
synonym: "H4R" EXACT []
synonym: "HH4R" EXACT []
synonym: "HRH4" EXACT PRO-short-label [PRO:DNx]
synonym: "AXOR35" EXACT []
synonym: "GPRv53" EXACT []
synonym: "SP9144" EXACT []
synonym: "GPCR105" RELATED Gene-based []
synonym: "Pfi-013" EXACT []
synonym: "G-protein coupled receptor 105" RELATED []
xref: IUPHARobj:265
is_a: PR:000049994 ! histamine receptor

[Term]
id: PR:Q9H3N8
name: histamine H4 receptor (human)
def: "An H4 histamine receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q9H3N8]
comment: Category=organism-gene.
synonym: "HRH4" RELATED Gene-based [UniProtKB:Q9H3N8]
synonym: "hHRH4" EXACT PRO-short-label [PRO:DNx]
synonym: "GPCR105" RELATED Gene-based [UniProtKB:Q9H3N8]
synonym: "H4R (human)" EXACT [UniProtKB:Q9H3N8]
synonym: "HH4R (human)" EXACT [UniProtKB:Q9H3N8]
synonym: "AXOR35 (human)" EXACT [UniProtKB:Q9H3N8]
synonym: "GPRv53 (human)" EXACT [UniProtKB:Q9H3N8]
synonym: "SP9144 (human)" EXACT [UniProtKB:Q9H3N8]
synonym: "Pfi-013 (human)" EXACT [UniProtKB:Q9H3N8]
synonym: "G-protein coupled receptor 105 (human)" BROAD [UniProtKB:Q9H3N8]
xref: UniProtKB:Q9H3N8
xref: Reactome:R-HSA-390910 "PR:Q9H3N8 located_in GO:0005886"
xref: DTO:02100233
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001565 ! H4 histamine receptor
relationship: has_gene_template HGNC:17383 ! HRH4 (human)

[Term]
id: PR:Q9H3N8-2
name: histamine H4 receptor isoform h2 (human)
def: "A histamine H4 receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H3N8-2." [PRO:DNx, UniProtKB:Q9H3N8]
comment: Category=organism-sequence.
synonym: "hHRH4/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9H3N8-2
is_a: PR:Q9H3N8 ! histamine H4 receptor (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9H3N8-1
name: histamine H4 receptor isoform h1 (human)
def: "A histamine H4 receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H3N8-1." [PRO:DNx, UniProtKB:Q9H3N8]
comment: Category=organism-sequence.
synonym: "hHRH4/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9H3N8-1
is_a: PR:Q9H3N8 ! histamine H4 receptor (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens