[Term]
id: PR:000001401
name: membrane cofactor protein
def: "A protein that is a translation product of the human CD46 gene or a 1:1 ortholog thereof. This protein act as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue." [PRO:JAN, UniProtKB:P15529]
comment: Category=gene.
synonym: "MCP" RELATED Gene-based []
synonym: "TLX" EXACT []
synonym: "CD46" EXACT PRO-short-label [PRO:DNx]
synonym: "MIC10" RELATED Gene-based []
synonym: "trophoblast leukocyte common antigen" EXACT []
xref: PIRSF:PIRSF037971
is_a: PR:000000001 ! protein