[Term]
id: PR:P22272
name: interleukin-6 receptor subunit alpha (mouse)
def: "An interleukin-6 receptor subunit alpha that is encoded in the genome of mouse." [OMA:P22272, PRO:DNx]
comment: Category=organism-gene.
synonym: "Il6r" RELATED Gene-based [UniProtKB:P22272]
synonym: "Il6ra" RELATED Gene-based [UniProtKB:P22272]
synonym: "mIL6R" EXACT PRO-short-label [PRO:DNx]
synonym: "CD126 (mouse)" EXACT [UniProtKB:P22272]
synonym: "IL-6RA (mouse)" EXACT [UniProtKB:P22272]
synonym: "IL-6R 1 (mouse)" EXACT [UniProtKB:P22272]
synonym: "IL-6R-alpha (mouse)" EXACT [UniProtKB:P22272]
synonym: "IL-6R subunit alpha (mouse)" EXACT [UniProtKB:P22272]
synonym: "IL-6 receptor subunit alpha (mouse)" EXACT [UniProtKB:P22272]
xref: UniProtKB:P22272
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001394 ! interleukin-6 receptor subunit alpha
relationship: has_gene_template MGI:105304 ! Il6ra (mouse)

[Term]
id: PR:P22273
name: interleukin-6 receptor subunit alpha (rat)
def: "An interleukin-6 receptor subunit alpha that is encoded in the genome of rat." [OMA:P22273, PANTHER:PTHR23036:SF27, PRO:DNx]
comment: Category=organism-gene.
synonym: "Il6r" RELATED Gene-based [UniProtKB:P22273]
synonym: "Il6ra" RELATED Gene-based [UniProtKB:P22273]
synonym: "rIL6R" EXACT PRO-short-label [PRO:DNx]
synonym: "CD126 (rat)" EXACT [UniProtKB:P22273]
synonym: "IL-6RA (rat)" EXACT [UniProtKB:P22273]
synonym: "IL-6R 1 (rat)" EXACT [UniProtKB:P22273]
synonym: "IL-6R-alpha (rat)" EXACT [UniProtKB:P22273]
synonym: "IL-6R subunit alpha (rat)" EXACT [UniProtKB:P22273]
synonym: "IL-6 receptor subunit alpha (rat)" EXACT [UniProtKB:P22273]
xref: UniProtKB:P22273
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000001394 ! interleukin-6 receptor subunit alpha
relationship: has_gene_template RGD:2902 ! Il6r (rat)

[Term]
id: PR:Q5DWQ5
name: interleukin-6 receptor alpha chain (chicken)
def: "An interleukin-6 receptor subunit alpha that is encoded in the genome of chicken." [PANTHER:PTHR23036:SF27, PRO:DNx]
comment: Category=organism-gene.
synonym: "chick-IL6R" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q5DWQ5
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000001394 ! interleukin-6 receptor subunit alpha
relationship: has_gene_template CGNC:54349 ! IL6R (chicken)

[Term]
id: PR:000054603
name: interleukin-6 receptor subunit alpha O-glycosylated 2 (human)
def: "An interleukin-6 receptor subunit alpha (human) that has been O-glycosylated at the residue equivalent to Thr-335 of the amino acid sequence represented by UniProtKB:P08887-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P08887-1, Thr-335, MOD:00005~GNO:G53434XO." [GlyGen:P08887-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hIL6R/OGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P08887-1, Thr-335, MOD:00005~GNO:G53434XO" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P08887 ! interleukin-6 receptor subunit alpha (human)
relationship: has_part GNO:G53434XO ! G53434XO
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000025429
name: interleukin-6 receptor subunit alpha proteolytic cleavage product
def: "An interleukin-6 receptor subunit alpha that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "IL6R/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000001394 ! interleukin-6 receptor subunit alpha

[Term]
id: PR:000018458
name: interleukin-6 receptor subunit alpha, signal peptide removed form
def: "An interleukin-6 receptor subunit alpha that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "IL6R/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000001394 ! interleukin-6 receptor subunit alpha
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000001394
name: interleukin-6 receptor subunit alpha
def: "A protein that is a translation product of the human IL6R gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "IL6R" EXACT PRO-short-label [PRO:DNx]
synonym: "gp80" EXACT []
synonym: "CD126" EXACT []
synonym: "Il6ra" RELATED Gene-based []
synonym: "IL-6RA" EXACT []
synonym: "IL-6R 1" EXACT []
synonym: "IL-6R-alpha" EXACT []
synonym: "IL-6R subunit alpha" EXACT []
synonym: "membrane glycoprotein 80" EXACT []
synonym: "IL-6 receptor subunit alpha" EXACT []
xref: IUPHARobj:1708
is_a: PR:000000001 ! protein

[Term]
id: PR:P08887-1
name: interleukin-6 receptor subunit alpha isoform 1 (human)
def: "An interleukin-6 receptor subunit alpha isoform 2 that is encoded in the genome of human." [PRO:HJD]
comment: Category=organism-sequence.
synonym: "hIL6R/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "interleukin-6 receptor subunit alpha isoform Long (human)" EXACT [UniProtKB:P08887]
xref: UniProtKB:P08887-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001795 ! interleukin-6 receptor subunit alpha isoform 2

[Term]
id: PR:000054602
name: interleukin-6 receptor subunit alpha O-glycosylated 1 (human)
def: "An interleukin-6 receptor subunit alpha (human) that has been O-glycosylated at the residue equivalent to Thr-329 of the amino acid sequence represented by UniProtKB:P08887-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08887-1, Thr-329, MOD:00005~GNO:G43417UB." [GlyGen:P08887-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hIL6R/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P08887-1, Thr-329, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P08887 ! interleukin-6 receptor subunit alpha (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000026630
name: interleukin-6 receptor subunit alpha isoform 1, signal peptide removed form
def: "An interleukin-6 receptor subunit alpha isoform 1 that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "IL6R/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000001794 ! interleukin-6 receptor subunit alpha isoform 1
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000026634
name: interleukin-6 receptor subunit alpha isoform 2, signal peptide removed form
def: "An interleukin-6 receptor subunit alpha isoform 2 that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "IL6R/iso:2/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000001795 ! interleukin-6 receptor subunit alpha isoform 2
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000001796
name: interleukin-6 receptor subunit alpha isoform 3
def: "An interleukin-6 receptor subunit alpha that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08887-2 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "IL6R/iso:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001394 ! interleukin-6 receptor subunit alpha

[Term]
id: PR:000001795
name: interleukin-6 receptor subunit alpha isoform 2
def: "An interleukin-6 receptor subunit alpha that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08887-1 or a 1:1 ortholog thereof." [PRO:HJD]
comment: Category=sequence.
synonym: "IL6R/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001394 ! interleukin-6 receptor subunit alpha

[Term]
id: PR:000001794
name: interleukin-6 receptor subunit alpha isoform 1
def: "An interleukin-6 receptor subunit alpha that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22272-1 or a 1:1 ortholog thereof." [PRO:HJD]
comment: Category=sequence.
synonym: "IL6R/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001394 ! interleukin-6 receptor subunit alpha

[Term]
id: PR:000044514
name: interleukin-6 receptor subunit alpha isoform 1 soluble form (mouse)
def: "An interleukin-6 receptor subunit alpha isoform 1 soluble form in mouse." [PRO:DNx]
comment: Category=organism-modification.
synonym: "mIL6R/iso:1/Clv:soluble" EXACT PRO-short-label [PRO:DAN]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001798 ! interleukin-6 receptor subunit alpha isoform 1 soluble form

[Term]
id: PR:P22272-1
name: interleukin-6 receptor subunit alpha isoform 1 (mouse)
def: "An interleukin-6 receptor subunit alpha isoform 1 that is encoded in the genome of mouse." [PRO:HJD]
comment: Category=organism-sequence.
synonym: "mIL6R/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P22272-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001794 ! interleukin-6 receptor subunit alpha isoform 1

[Term]
id: PR:P08887
name: interleukin-6 receptor subunit alpha (human)
def: "An interleukin-6 receptor subunit alpha that is encoded in the genome of human." [PRO:WCB, UniProtKB:P08887]
comment: Category=organism-gene.
synonym: "IL6R" RELATED Gene-based [UniProtKB:P08887]
synonym: "hIL6R" EXACT PRO-short-label [PRO:DNx]
synonym: "gp80 (human)" EXACT [UniProtKB:P08887]
synonym: "CD126 (human)" EXACT [UniProtKB:P08887]
synonym: "IL-6RA (human)" EXACT [UniProtKB:P08887]
synonym: "IL-6R 1 (human)" EXACT [UniProtKB:P08887]
synonym: "IL-6R-alpha (human)" EXACT [UniProtKB:P08887]
synonym: "IL-6R subunit alpha (human)" EXACT [UniProtKB:P08887]
synonym: "membrane glycoprotein 80 (human)" EXACT [UniProtKB:P08887]
synonym: "IL-6 receptor subunit alpha (human)" EXACT [UniProtKB:P08887]
xref: UniProtKB:P08887
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001394 ! interleukin-6 receptor subunit alpha
relationship: has_gene_template HGNC:6019 ! IL6R (human)

[Term]
id: PR:000048029
name: interleukin-6 receptor subunit alpha, signal peptide removed form (human)
def: "An interleukin-6 receptor subunit alpha (human) that has had the signal peptide removed. UniProtKB:P08887, 20-468." [PRO:DNx, Reactome:R-HSA-197824]
comment: Category=organism-modification.
synonym: "hIL6R/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000010895" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P08887, 20-468" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-197824 "PR:000048029 located_in GO:0005886"
intersection_of: PR:P08887 ! interleukin-6 receptor subunit alpha (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P08887-2
name: interleukin-6 receptor subunit alpha isoform 2 (human)
def: "An interleukin-6 receptor subunit alpha isoform 3 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hIL6R/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "interleukin-6 receptor subunit alpha isoform Short (human)" EXACT [UniProtKB:P08887]
xref: UniProtKB:P08887-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001796 ! interleukin-6 receptor subunit alpha isoform 3

[Term]
id: PR:000001798
name: interleukin-6 receptor subunit alpha isoform 1 soluble form
def: "An interleukin-6 receptor subunit alpha isoform 1 that has been post-translationally cleaved to release the extracellular domain into the extracellular space." [PMID:8477802, PRO:HJD]
comment: Category=modification.
synonym: "sIL-6R" EXACT []
synonym: "IL6R/iso:1/Clv:soluble" EXACT PRO-short-label [PRO:DAN]
is_a: PR:000001794 ! interleukin-6 receptor subunit alpha isoform 1
relationship: output_of GO:0016485 ! protein processing