[Term]
id: PR:000001393
name: interleukin-6
def: "A protein that is a translation product of the human IL6 gene or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=gene.
synonym: "CDF" EXACT []
synonym: "IL6" EXACT PRO-short-label [PRO:DNx]
synonym: "IL-6" EXACT []
synonym: "BSF-2" EXACT []
synonym: "IFNB2" RELATED Gene-based []
synonym: "IFN-beta-2" EXACT []
synonym: "interleukin HP-1" EXACT []
synonym: "interferon beta-2" EXACT []
synonym: "hybridoma growth factor" EXACT []
synonym: "CTL differentiation factor" EXACT []
synonym: "B-cell stimulatory factor 2" EXACT []
synonym: "B-cell hybridoma growth factor" EXACT []
xref: PIRSF:PIRSF001935
is_a: PR:000000001 ! protein

[Term]
id: PR:P20607
name: interleukin-6 (rat)
def: "An interleukin-6 that is encoded in the genome of rat." [OMA:P20607, PANTHER:PTHR11457:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "Il6" RELATED Gene-based [UniProtKB:P20607]
synonym: "Il-6" RELATED Gene-based [UniProtKB:P20607]
synonym: "rIL6" EXACT PRO-short-label [PRO:DNx]
synonym: "IL-6 (rat)" EXACT [UniProtKB:P20607]
xref: UniProtKB:P20607
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000001393 ! interleukin-6
relationship: has_gene_template RGD:2901 ! Il6 (rat)

[Term]
id: PR:000018456
name: interleukin-6, signal peptide removed form
def: "An interleukin-6 that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "IL6/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000001393 ! interleukin-6
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:P08505-1
name: interleukin-6 isoform 1 (mouse)
def: "An interleukin-6 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mIL6/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P08505-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038739 ! interleukin-6 isoform 1

[Term]
id: PR:P08505
name: interleukin-6 (mouse)
def: "An interleukin-6 that is encoded in the genome of mouse." [OMA:P08505, PRO:DNx]
comment: Category=organism-gene.
synonym: "Il6" RELATED Gene-based [UniProtKB:P08505]
synonym: "Il-6" RELATED Gene-based [UniProtKB:P08505]
synonym: "mIL6" EXACT PRO-short-label [PRO:DNx]
synonym: "IL-6 (mouse)" EXACT [UniProtKB:P08505]
synonym: "interleukin HP-1 (mouse)" EXACT [UniProtKB:P08505]
synonym: "B-cell hybridoma growth factor (mouse)" EXACT [UniProtKB:P08505]
xref: UniProtKB:P08505
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001393 ! interleukin-6
relationship: has_gene_template MGI:96559 ! Il6 (mouse)

[Term]
id: PR:P05231
name: interleukin-6 (human)
def: "An interleukin-6 that is encoded in the genome of human." [PRO:JAN, UniProtKB:P05231]
comment: Category=organism-gene.
synonym: "IL6" RELATED Gene-based [UniProtKB:P05231]
synonym: "hIL6" EXACT PRO-short-label [PRO:DNx]
synonym: "IFNB2" RELATED Gene-based [UniProtKB:P05231]
synonym: "CDF (human)" EXACT [UniProtKB:P05231]
synonym: "IL-6 (human)" EXACT [UniProtKB:P05231]
synonym: "BSF-2 (human)" EXACT [UniProtKB:P05231]
synonym: "IFN-beta-2 (human)" EXACT [UniProtKB:P05231]
synonym: "interferon beta-2 (human)" EXACT [UniProtKB:P05231]
synonym: "hybridoma growth factor (human)" EXACT [UniProtKB:P05231]
synonym: "CTL differentiation factor (human)" EXACT [UniProtKB:P05231]
synonym: "B-cell stimulatory factor 2 (human)" EXACT [UniProtKB:P05231]
xref: UniProtKB:P05231
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001393 ! interleukin-6
relationship: has_gene_template HGNC:6018 ! IL6 (human)

[Term]
id: PR:000048028
name: interleukin-6, signal peptide removed form (human)
def: "An interleukin-6 (human) that has had the signal peptide removed. UniProtKB:P05231, 30-212." [PRO:DNx, Reactome:R-HSA-447100]
comment: Category=organism-modification.
synonym: "hIL6/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000015582" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P05231, 30-212" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-447100 "PR:000048028 located_in GO:0005576"
xref: Reactome:R-HSA-8956764 "PR:000048028 located_in GO:0005788"
intersection_of: PR:P05231 ! interleukin-6 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000038739
name: interleukin-6 isoform 1
def: "An interleukin-6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08505-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "IL6/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001393 ! interleukin-6

[Term]
id: PR:P20607-1
name: interleukin-6 isoform 1 (rat)
def: "An interleukin-6 isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rIL6/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P20607-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000038739 ! interleukin-6 isoform 1

[Term]
id: PR:Q90YI0
name: interleukin-6 (chicken)
def: "An interleukin-6 that is encoded in the genome of chicken." [PANTHER:PTHR11457:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "IL6" RELATED Gene-based [UniProtKB:Q90YI0]
synonym: "chick-IL6" EXACT PRO-short-label [PRO:DNx]
synonym: "IL-6 (chicken)" EXACT [UniProtKB:Q90YI0]
synonym: "ChIL-6 (chicken)" EXACT [UniProtKB:Q90YI0]
xref: UniProtKB:Q90YI0
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000001393 ! interleukin-6
relationship: has_gene_template NCBIGene:395337 ! IL6 (chicken)