[Term]
id: PR:P60568
name: interleukin-2 (human)
def: "An interleukin-2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P60568]
comment: Category=organism-gene.
synonym: "IL2" RELATED Gene-based [UniProtKB:P60568]
synonym: "hIL2" EXACT PRO-short-label [PRO:DNx]
synonym: "IL-2 (human)" EXACT [UniProtKB:P60568]
synonym: "TCGF (human)" EXACT [UniProtKB:P60568]
synonym: "aldesleukin (human)" EXACT [UniProtKB:P60568]
synonym: "T-cell growth factor (human)" EXACT [UniProtKB:P60568]
xref: UniProtKB:P60568
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001379 ! interleukin-2
relationship: has_gene_template HGNC:6001 ! IL2 (human)

[Term]
id: PR:000001379
name: interleukin-2
def: "A protein that is a translation product of the human IL2 gene or a 1:1 ortholog thereof. Interleukin-2 has a dual role in maintaining tolerance and contributing to immunity." [PMID:18062768, PRO:CNA]
comment: Category=gene.
synonym: "IL2" EXACT PRO-short-label [PRO:DNx]
synonym: "IL-2" EXACT []
synonym: "TCGF" EXACT []
synonym: "aldesleukin" EXACT []
synonym: "T-cell growth factor" EXACT []
xref: PIRSF:PIRSF001938
is_a: PR:000000001 ! protein

[Term]
id: PR:P04351
name: interleukin-2 (mouse)
def: "An interleukin-2 that is encoded in the genome of mouse." [OMA:P04351, PRO:DNx]
comment: Category=organism-gene.
synonym: "Il2" RELATED Gene-based [UniProtKB:P04351]
synonym: "Il-2" RELATED Gene-based [UniProtKB:P04351]
synonym: "mIL2" EXACT PRO-short-label [PRO:DNx]
synonym: "IL-2 (mouse)" EXACT [UniProtKB:P04351]
synonym: "TCGF (mouse)" EXACT [UniProtKB:P04351]
synonym: "T-cell growth factor (mouse)" EXACT [UniProtKB:P04351]
xref: UniProtKB:P04351
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001379 ! interleukin-2
relationship: has_gene_template MGI:96548 ! Il2 (mouse)

[Term]
id: PR:000018442
name: interleukin-2, signal peptide removed form
def: "An interleukin-2 that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "IL2/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000001379 ! interleukin-2
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000056668
name: interleukin-2 O-glycosylated 3 (human)
def: "An interleukin-2 (human) that has been O-glycosylated at the residue equivalent to Thr-23 of the amino acid sequence represented by UniProtKB:P60568-1, in which the glycan structure is represented by GlyTouCan:G65562ZE. Example: UniProtKB:P60568-1, Thr-23, MOD:00005~GNO:G65562ZE." [GlyGen:P60568-1, PMID:10861392, PMID:2793860, PMID:3935432, PMID:8344280, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hIL2/OGlyco:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P60568-1, Thr-23, MOD:00005~UniCarbKB:7" NARROW [PRO:DNx]
synonym: "UniProtKB:P60568-1, Thr-23, MOD:00005~GNO:G65562ZE" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P60568 ! interleukin-2 (human)
relationship: has_part GNO:G65562ZE ! G65562ZE
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048003
name: interleukin-2, signal peptide removed form (human)
def: "An interleukin-2 (human) that has had the signal peptide removed. UniProtKB:P60568, 21-153." [PRO:DNx, Reactome:R-HSA-447099]
comment: Category=organism-modification.
synonym: "hIL2/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000015484" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P60568, 21-153" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-447099 "PR:000048003 located_in GO:0005576"
intersection_of: PR:P60568 ! interleukin-2 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P17108
name: interleukin-2 (rat)
def: "An interleukin-2 that is encoded in the genome of rat." [OMA:P17108, PANTHER:PTHR11443:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "Il2" RELATED Gene-based [UniProtKB:P17108]
synonym: "Il-2" RELATED Gene-based [UniProtKB:P17108]
synonym: "rIL2" EXACT PRO-short-label [PRO:DNx]
synonym: "IL-2 (rat)" EXACT [UniProtKB:P17108]
synonym: "TCGF (rat)" EXACT [UniProtKB:P17108]
synonym: "T-cell growth factor (rat)" EXACT [UniProtKB:P17108]
xref: UniProtKB:P17108
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000001379 ! interleukin-2
relationship: has_gene_template RGD:620047 ! Il2 (rat)

[Term]
id: PR:000056667
name: interleukin-2 O-glycosylated 2 (human)
def: "An interleukin-2 (human) that has been O-glycosylated at the residue equivalent to Thr-23 of the amino acid sequence represented by UniProtKB:P60568-1, in which the glycan structure is represented by GlyTouCan:G01614ZM. Example: UniProtKB:P60568-1, Thr-23, MOD:00005~GNO:G01614ZM." [GlyGen:P60568-1, PMID:10861392, PMID:2793860, PMID:3935432, PMID:8344280, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hIL2/OGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P60568-1, Thr-23, MOD:00005~GNO:G01614ZM" NARROW PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P60568-1, Thr-23, MOD:00005~UniCarbKB:96" NARROW [PRO:DNx]
is_a: PR:P60568 ! interleukin-2 (human)
relationship: has_part GNO:G01614ZM ! G01614ZM
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000056666
name: interleukin-2 O-glycosylated 1 (human)
def: "An interleukin-2 (human) that has been O-glycosylated at the residue equivalent to Thr-23 of the amino acid sequence represented by UniProtKB:P60568-1, in which the glycan structure is represented by GlyTouCan:G00031MO. Example: UniProtKB:P60568-1, Thr-23, MOD:00005~GNO:G00031MO." [GlyGen:P60568-1, PMID:10861392, PMID:2793860, PMID:3935432, PMID:8344280, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hIL2/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P60568-1, Thr-23, MOD:00005~UniCarbKB:4" NARROW [PRO:DNx]
synonym: "UniProtKB:P60568-1, Thr-23, MOD:00005~GNO:G00031MO" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P60568 ! interleukin-2 (human)
relationship: has_part GNO:G00031MO ! G00031MO
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens