[Term]
id: PR:000001339
name: cytokine receptor common subunit beta
def: "A protein that is a translation product of the human CSF2RB gene or a 1:1 ortholog thereof. This gene encodes the receptor beta chain shared by high-affinity IL5, IL3, and GM-CSF receptors. In mouse, there is also a closely related gene that encodes an IL3-specific beta chain." [PRO:WCB, UniProtKB:P26954]
comment: Category=gene.
synonym: "Aic2b" RELATED []
synonym: "CD131" EXACT []
synonym: "IL3RB" RELATED Gene-based []
synonym: "IL5RB" RELATED Gene-based []
synonym: "CDw131" EXACT []
synonym: "CSF2RB" EXACT PRO-short-label [PRO:DNx]
synonym: "Il3rb1" RELATED []
synonym: "Csf2rb1" RELATED []
synonym: "cytokine receptor common beta chain" EXACT []
synonym: "GM-CSF/IL-3/IL-5 receptor common beta subunit" EXACT []
xref: IUPHARobj:2306
is_a: PR:000000001 ! protein

[Term]
id: PR:000047083
name: cytokine receptor common subunit beta, signal peptide removed phosphorylated 1 (human)
def: "A cytokine receptor common subunit beta (human) that has had the signal peptide removed and has been post-translationally modified to include phosphoserine at position 585 of the amino acid sequence represented by UniProtKB:P32927. UniProtKB:P32927, 17-897, Ser-585, MOD:00046." [PRO:DNx, Reactome:R-HSA-914170]
comment: Category=organism-modification.
synonym: "hCSF2RB/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000010862, Ser-585, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P32927, 17-897, Ser-585, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-914170 "PR:000047083 located_in GO:0005886"
is_a: PR:P32927 ! cytokine receptor common subunit beta (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000047082
name: cytokine receptor common subunit beta, signal peptide removed form (human)
def: "A cytokine receptor common subunit beta (human) that has had the signal peptide removed. UniProtKB:P32927, 17-897." [PRO:DNx, Reactome:R-HSA-879960]
comment: Category=organism-modification.
synonym: "PRO_0000010862" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hCSF2RB/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P32927, 17-897" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-879960 "PR:000047082 located_in GO:0005886"
intersection_of: PR:P32927 ! cytokine receptor common subunit beta (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000047085
name: cytokine receptor common subunit beta, signal peptide removed phosphorylated 3 (human)
def: "A cytokine receptor common subunit beta (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 593 and 628 of the amino acid sequence represented by UniProtKB:P32927. UniProtKB:P32927, 17-897, Tyr-593/Tyr-628, MOD:00048." [PRO:DNx, Reactome:R-HSA-912312]
comment: Category=organism-modification.
synonym: "hCSF2RB/SigPep-/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000010862, Tyr-593/Tyr-628, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P32927, 17-897, Tyr-593/Tyr-628, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-912312 "PR:000047085 located_in GO:0005886"
is_a: PR:P32927 ! cytokine receptor common subunit beta (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000047084
name: cytokine receptor common subunit beta, signal peptide removed phosphorylated 2 (human)
def: "A cytokine receptor common subunit beta (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at position 593 of the amino acid sequence represented by UniProtKB:P32927. UniProtKB:P32927, 17-897, Tyr-593, MOD:00048." [PRO:DNx, Reactome:R-HSA-914092]
comment: Category=organism-modification.
synonym: "hCSF2RB/SigPep-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000010862, Tyr-593, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P32927, 17-897, Tyr-593, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-914092 "PR:000047084 located_in GO:0005886"
is_a: PR:P32927 ! cytokine receptor common subunit beta (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000044814
name: cytokine receptor common subunit beta isoform 1 phosphorylated 1 (human)
def: "A cytokine receptor common subunit beta isoform 1 (human) that has been phosphorylated in the Ser residue within the 14-3-3 recognition motif RSXSXP. UniProtKB:P32927-1, Ser-601, MOD:00046." [PMID:10477722, PMID:10949031, PRO:CNA]
comment: Category=organism-modification. Evidence=(ECO:0000006, PMID:10477722). Note: Proteoform created based on papers selected via the eFIP text mining tool. The site coordinate described in PMID:10477722 differs in from the one here because signal peptide is not considered in numbering.
synonym: "hCSF2RB/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "Bc phosphorylated 1 (human)" EXACT []
synonym: "beta c phosphorylated 1 (human)" RELATED []
synonym: "UniProtKB:P32927-1, Ser-601, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "CSF2RB isoform 1 phosphorylated 1 (human)" EXACT []
is_a: PR:P32927-1 ! cytokine receptor common subunit beta isoform 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P32927
name: cytokine receptor common subunit beta (human)
def: "A cytokine receptor common subunit beta that is encoded in the genome of human." [PRO:WCB, UniProtKB:P32927]
comment: Category=organism-gene.
synonym: "IL3RB" RELATED Gene-based [UniProtKB:P32927]
synonym: "IL5RB" RELATED Gene-based [UniProtKB:P32927]
synonym: "CSF2RB" RELATED Gene-based [UniProtKB:P32927]
synonym: "hCSF2RB" EXACT PRO-short-label [PRO:DNx]
synonym: "CD131 (human)" EXACT [UniProtKB:P32927]
synonym: "CDw131 (human)" EXACT [UniProtKB:P32927]
synonym: "GM-CSF/IL-3/IL-5 receptor common beta subunit (human)" EXACT [UniProtKB:P32927]
xref: UniProtKB:P32927
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001339 ! cytokine receptor common subunit beta
relationship: has_gene_template HGNC:2436 ! CSF2RB (human)

[Term]
id: PR:P32927-2
name: cytokine receptor common subunit beta isoform h2 (human)
def: "A cytokine receptor common subunit beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P32927-2." [PRO:DNx, UniProtKB:P32927]
comment: Category=organism-sequence.
synonym: "hCSF2RB/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P32927-2
is_a: PR:P32927 ! cytokine receptor common subunit beta (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P32927-1
name: cytokine receptor common subunit beta isoform 1 (human)
def: "A cytokine receptor common subunit beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P32927-1." [PRO:DNx, UniProtKB:P32927]
comment: Category=organism-sequence.
synonym: "hCSF2RB/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P32927-1
is_a: PR:P32927 ! cytokine receptor common subunit beta (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens