[Term]
id: PR:000001322
name: angiotensin-converting enzyme
def: "A protein that is a translation product of the human ACE gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "ACE" EXACT PRO-short-label [PRO:DNx]
synonym: "DCP" RELATED Gene-based []
synonym: "DCP1" RELATED Gene-based []
synonym: "CD143" EXACT []
synonym: "kininase II" EXACT []
synonym: "dipeptidyl carboxypeptidase I" EXACT []
synonym: "angiotensin-converting enzyme, somatic isoform" EXACT []
xref: IUPHARobj:1613
is_a: PR:000000001 ! protein

[Term]
id: PR:P12821-1
name: angiotensin-converting enzyme isoform hSomatic-1 (human)
def: "An angiotensin-converting enzyme (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P12821-1." [PRO:DNx, UniProtKB:P12821]
comment: Category=organism-sequence.
synonym: "hACE/iso:hSomatic-1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P12821-1
is_a: PR:P12821 ! angiotensin-converting enzyme (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P12821-2
name: angiotensin-converting enzyme isoform hSomatic-2 (human)
def: "An angiotensin-converting enzyme (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P12821-2." [PRO:DNx, UniProtKB:P12821]
comment: Category=organism-sequence.
synonym: "hACE/iso:hSomatic-2" EXACT PRO-short-label [PRO:DNx]
synonym: "angiotensin-converting enzyme isoform Soluble (human)" EXACT [UniProtKB:P12821]
xref: UniProtKB:P12821-2
is_a: PR:P12821 ! angiotensin-converting enzyme (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P12821-3
name: angiotensin-converting enzyme isoform Testis-specific (human)
def: "An angiotensin-converting enzyme (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P12821-3." [PRO:DNx, UniProtKB:P12821]
comment: Category=organism-sequence.
synonym: "hACE/iso:Testis-specific" EXACT PRO-short-label [PRO:DNx]
synonym: "angiotensin-converting enzyme isoform ACE-T (human)" EXACT [UniProtKB:P12821]
xref: UniProtKB:P12821-3
is_a: PR:P12821 ! angiotensin-converting enzyme (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P12821-4
name: angiotensin-converting enzyme isoform h4 (human)
def: "An angiotensin-converting enzyme (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P12821-4." [PRO:DNx, UniProtKB:P12821]
comment: Category=organism-sequence.
synonym: "hACE/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P12821-4
is_a: PR:P12821 ! angiotensin-converting enzyme (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046237
name: angiotensin-converting enzyme, signal peptide removed form (human)
def: "An angiotensin-converting enzyme (human) that has had the signal peptide removed. UniProtKB:P12821, 30-1306." [PRO:DNx, Reactome:R-HSA-508496]
comment: Category=organism-modification.
synonym: "hACE/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000028530" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P12821, 30-1306" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-508496 "PR:000046237 located_in GO:0005886"
intersection_of: PR:P12821 ! angiotensin-converting enzyme (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000055028
name: angiotensin-converting enzyme N-glycosylated 1 (human)
def: "An angiotensin-converting enzyme (human) that has been N-glycosylated at the residue equivalent to Asn-714 of the amino acid sequence represented by UniProtKB:P12821-1, in which the glycan composition is represented by GlyTouCan:G02815KT. Example: UniProtKB:P12821-1, Asn-714, MOD:00160~GNO:G02815KT." [GlyGen:P12821-1, PMID:26791533, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hACE/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P12821-1, Asn-714, MOD:00160~GNO:G02815KT" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P12821 ! angiotensin-converting enzyme (human)
relationship: has_part GNO:G02815KT ! G02815KT
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000055029
name: angiotensin-converting enzyme N-glycosylated 2 (human)
def: "An angiotensin-converting enzyme (human) that has been N-glycosylated at the residue equivalent to Asn-714 of the amino acid sequence represented by UniProtKB:P12821-1, in which the glycan composition is represented by GlyTouCan:G31852PQ. Example: UniProtKB:P12821-1, Asn-714, MOD:00160~GNO:G31852PQ." [GlyGen:P12821-1, PMID:26791533, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hACE/NGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P12821-1, Asn-714, MOD:00160~GNO:G31852PQ" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P12821 ! angiotensin-converting enzyme (human)
relationship: has_part GNO:G31852PQ ! G31852PQ
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P12821
name: angiotensin-converting enzyme (human)
def: "An angiotensin-converting enzyme that is encoded in the genome of human." [PRO:WCB, UniProtKB:P12821]
comment: Category=organism-gene.
synonym: "ACE" RELATED Gene-based [UniProtKB:P12821]
synonym: "DCP" RELATED Gene-based [UniProtKB:P12821]
synonym: "DCP1" RELATED Gene-based [UniProtKB:P12821]
synonym: "hACE" EXACT PRO-short-label [PRO:DNx]
synonym: "CD143 (human)" EXACT [UniProtKB:P12821]
synonym: "kininase II (human)" EXACT [UniProtKB:P12821]
synonym: "dipeptidyl carboxypeptidase I (human)" EXACT [UniProtKB:P12821]
xref: UniProtKB:P12821
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001322 ! angiotensin-converting enzyme
relationship: has_gene_template HGNC:2707 ! ACE (human)