[Term]
id: PR:000001315
name: frizzled-like G-protein coupled receptor
def: "A G-protein coupled receptor with core architecture consisting of an Fz domain (Pfam:PF01392), also known as Frizzled CRD (cysteine rich domain), followed by a Frizzled/Smoothened family membrane region (Pfam:PF01534), which includes 7 transmembrane helices, and a cytoplasmic domain containing the motif Lys-Thr-x-x-x-Trp. They generally function as cell-surface receptors for Wnts." [InterPro:IPR015526, PRO:DAN, PRO:WCB]
comment: Category=family. Classification based on GRAFS system. [PMID:12761335]
synonym: "fam:frizzled" EXACT PRO-short-label [PRO:DAN]
synonym: "class F G-protein coupled receptor" EXACT [IUPHARfam:25]
xref: IUPHAR:GPCRListForward?class=frizzled
xref: IUPHARfam:25
xref: PIRSF:PIRSF006696
is_a: PR:000030035 ! G-protein coupled receptor