[Term]
id: PR:000026585
name: Toll-like receptor 4 isoform 1, signal peptide removed form
def: "A Toll-like receptor 4 isoform 1 that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "TLR4/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000025490 ! Toll-like receptor 4 isoform 1
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000025492
name: Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1
def: "A Toll-like receptor 4 isoform 1 that is the mature N-glycosylated form. Example: UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160." [PMID:11706042, PMID:19252480]
comment: Category=modification.
synonym: "TLR4 glycosylated" RELATED []
synonym: "TLR4/iso:1/SigPep-/NGlyco:1" EXACT PRO-short-label [PRO:DAN]
is_a: PR:000025490 ! Toll-like receptor 4 isoform 1
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:Q9QX05
name: Toll-like receptor 4 (rat)
def: "A Toll-like receptor 4 that is encoded in the genome of rat." [PANTHER:PTHR24365:SF55, PRO:DNx]
comment: Category=organism-gene.
synonym: "Tlr4" RELATED Gene-based [UniProtKB:Q9QX05]
synonym: "rTLR4" EXACT PRO-short-label [PRO:DNx]
synonym: "CD284 (rat)" EXACT [UniProtKB:Q9QX05]
synonym: "Toll4 (rat)" EXACT [UniProtKB:Q9QX05]
xref: UniProtKB:Q9QX05
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000001155 ! Toll-like receptor 4
relationship: has_gene_template RGD:3870 ! Tlr4 (rat)

[Term]
id: PR:000025787
name: Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
def: "A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160." [PMID:11706042, PMID:19252480]
comment: Category=organism-modification. Note: The Reactome cross-reference cites only glycosylations at positions 526 and 575, as these were found to be the key functional modifications. Nonetheless, structural studies indicate the modifications listed here provide a more-complete representation. [PRO:DAN, PMID:11706042]
synonym: "hTLR4/iso:1/SigPep-/NGlyco:1" EXACT PRO-short-label [PRO:DAN]
synonym: "Toll-like receptor 4 isoform 1 cleaved and glycosylated 1 (human)" EXACT []
synonym: "PRO_0000034722, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-166045 "PR:000025787 located_in GO:0005886"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025492 ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: PR:O00206
name: Toll-like receptor 4 (human)
def: "A Toll-like receptor 4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O00206]
comment: Category=organism-gene.
synonym: "TLR4" RELATED Gene-based [UniProtKB:O00206]
synonym: "hTLR4" EXACT PRO-short-label [PRO:DNx]
synonym: "hToll" EXACT [UniProtKB:O00206]
synonym: "CD284 (human)" EXACT [UniProtKB:O00206]
xref: UniProtKB:O00206
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001155 ! Toll-like receptor 4
relationship: has_gene_template HGNC:11850 ! TLR4 (human)

[Term]
id: PR:000001155
name: Toll-like receptor 4
def: "A Toll-like receptor that is a translation product of the human TLR4 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "Lps" RELATED Gene-based []
synonym: "TLR4" EXACT PRO-short-label [PRO:DNx]
synonym: "Toll" BROAD [PRO:DAN]
synonym: "CD284" EXACT []
xref: IUPHARobj:1754
is_a: PR:000001096 ! Toll-like receptor

[Term]
id: PR:000036075
name: Toll-like receptor 4 isoform 1, signal peptide removed form (human)
def: "A Toll-like receptor 4 isoform 1, signal peptide removed form in human. UniProtKB:O00206-1, 24-839." [PRO:DNx, UniProtKB:O00206]
comment: Category=organism-modification.
synonym: "PRO_0000034722" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hTLR4/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O00206-1, 24-839" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2201285 "PR:000036075 located_in GO:0010008"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026585 ! Toll-like receptor 4 isoform 1, signal peptide removed form

[Term]
id: PR:Q9QUK6-1
name: Toll-like receptor 4 isoform 1 (mouse)
def: "A Toll-like receptor 4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mTLR4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9QUK6-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000025490 ! Toll-like receptor 4 isoform 1

[Term]
id: PR:000018359
name: Toll-like receptor 4, signal peptide removed form
def: "A Toll-like receptor 4 that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "TLR4/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000001155 ! Toll-like receptor 4
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000025490
name: Toll-like receptor 4 isoform 1
def: "A Toll-like receptor 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00206-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "TLR4/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001155 ! Toll-like receptor 4

[Term]
id: PR:000025491
name: Toll-like receptor 4 isoform 2
def: "A Toll-like receptor 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00206-2 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "TLR4/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001155 ! Toll-like receptor 4

[Term]
id: PR:Q9QUK6
name: Toll-like receptor 4 (mouse)
def: "A Toll-like receptor 4 that is encoded in the genome of mouse." [OMA:Q9QUK6, PRO:DNx]
comment: Category=organism-gene.
synonym: "Lps" RELATED Gene-based [UniProtKB:Q9QUK6]
synonym: "Tlr4" RELATED Gene-based [UniProtKB:Q9QUK6]
synonym: "mTLR4" EXACT PRO-short-label [PRO:DNx]
synonym: "CD284 (mouse)" EXACT [UniProtKB:Q9QUK6]
xref: UniProtKB:Q9QUK6
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001155 ! Toll-like receptor 4
relationship: has_gene_template MGI:96824 ! Tlr4 (mouse)

[Term]
id: PR:000027172
name: Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
def: "A Toll-like receptor 4 isoform 1, signal peptide removed form in mouse that has been N-glycosylated on Asn residues at positions 34, 75, 172, 204, 237, 307, 492, 524 and 572 of the amino acid sequence represented by UniProtKB:Q9QUK6-1. UniProtKB:Q9QUK6-1, 26-835, Asn-34/Asn-75/Asn-172/Asn-204/Asn-237/Asn-307/Asn-492/Asn-524/Asn-572, MOD:00160." [PMID:17803912, PRO:CNA]
comment: Category=organism-modification.
synonym: "mTLR4/iso:1/SigPep-/NGlyco:1" EXACT PRO-short-label [PRO:DAN]
synonym: "Toll-like receptor 4 isoform 1 cleaved and glycosylated 1 (mouse)" EXACT []
synonym: "PRO_0000034723, Asn-34/Asn-75/Asn-172/Asn-204/Asn-237/Asn-307/Asn-492/Asn-524/Asn-572, MOD:00160" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q9QUK6-1, 26-835, Asn-34/Asn-75/Asn-172/Asn-204/Asn-237/Asn-307/Asn-492/Asn-524/Asn-572, MOD:00160" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:000026585 ! Toll-like receptor 4 isoform 1, signal peptide removed form
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q7ZTG5
name: Toll-like receptor 4 (chicken)
def: "A Toll-like receptor 4 that is encoded in the genome of chicken." [PMID:18768894, PMID:20483729, PRO:CNA]
comment: Category=organism-gene.
synonym: "chTLR4" EXACT [PMID:18768894]
synonym: "chick-TLR4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q7ZTG5
xref: Reactome:R-GGA-433970 "PR:Q7ZTG5 located_in GO:0005886"
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000001155 ! Toll-like receptor 4
relationship: has_gene_template CGNC:5282 ! TLR4 (chicken)

[Term]
id: PR:O00206-1
name: Toll-like receptor 4 isoform 1 (human)
def: "A Toll-like receptor 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hTLR4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O00206-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025490 ! Toll-like receptor 4 isoform 1

[Term]
id: PR:O00206-3
name: Toll-like receptor 4 isoform h3 (human)
def: "A Toll-like receptor 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00206-3." [PRO:DNx, UniProtKB:O00206]
comment: Category=organism-sequence.
synonym: "hTLR4/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O00206-3
is_a: PR:O00206 ! Toll-like receptor 4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O00206-2
name: Toll-like receptor 4 isoform 2 (human)
def: "A Toll-like receptor 4 isoform 2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hTLR4/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O00206-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025491 ! Toll-like receptor 4 isoform 2