[Term]
id: PR:000025404
name: T-cell surface glycoprotein CD8 alpha chain isoform 2
def: "A T-cell surface glycoprotein CD8 alpha chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01732-2 or a 1:1 ortholog thereof. Lacking the transmembrane domain found in isoform mCD8alpha, this form is therefore secreted." [PRO:DAN]
comment: Category=sequence.
synonym: "sCD8alpha" EXACT []
synonym: "CD8A/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "CD8alpha secreted form" EXACT []
is_a: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain

[Term]
id: PR:000025406
name: T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form
def: "A T-cell surface glycoprotein CD8 alpha chain isoform 1 that has had the signal peptide removed to yield the mature form." [PRO:DAN]
comment: Category=modification.
synonym: "CD8A/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000025403 ! T-cell surface glycoprotein CD8 alpha chain isoform 1
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000046653
name: T-cell surface glycoprotein CD8 alpha chain, signal peptide removed form (human)
def: "A T-cell surface glycoprotein CD8 alpha chain (human) that has had the signal peptide removed. UniProtKB:P01732, 22-235." [PRO:DNx, Reactome:R-HSA-197601]
comment: Category=organism-modification.
synonym: "hCD8A/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000014638" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P01732, 22-235" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-197601 "PR:000046653 located_in GO:0005886"
intersection_of: PR:P01732 ! T-cell surface glycoprotein CD8 alpha chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000025403
name: T-cell surface glycoprotein CD8 alpha chain isoform 1
def: "A T-cell surface glycoprotein CD8 alpha chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01732-1 or a 1:1 ortholog thereof. Having a single-pass transmembrane domain, this form is membrane bound." [PRO:DAN]
comment: Category=sequence. Requested by=CL.
synonym: "mCD8alpha" EXACT []
synonym: "CD8A/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain

[Term]
id: PR:000052043
name: T-cell surface glycoprotein CD8 alpha chain O-glycosylated 2 (human)
def: "A T-cell surface glycoprotein CD8 alpha chain (human) that has been O-glycosylated at the residue equivalent to Ser-158 of the amino acid sequence represented by UniProtKB:P01732-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P01732-1, Ser-158, MOD:00002~GNO:G43417UB." [GlyGen:P01732-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hCD8A/OGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01732-1, Ser-158, MOD:00002~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P01732 ! T-cell surface glycoprotein CD8 alpha chain (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000052042
name: T-cell surface glycoprotein CD8 alpha chain O-glycosylated 1 (human)
def: "A T-cell surface glycoprotein CD8 alpha chain (human) that has been O-glycosylated at the residue equivalent to Ser-158 of the amino acid sequence represented by UniProtKB:P01732-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P01732-1, Ser-158, MOD:00002~GNO:G29068FM." [GlyGen:P01732-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hCD8A/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01732-1, Ser-158, MOD:00002~GNO:G29068FM" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P01732 ! T-cell surface glycoprotein CD8 alpha chain (human)
relationship: has_part GNO:G29068FM ! G29068FM
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000018335
name: T-cell surface glycoprotein CD8 alpha chain, signal peptide removed form
def: "A T-cell surface glycoprotein CD8 alpha chain that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "CD8A/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000025408
name: T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed glycosylated form
def: "A T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form that includes at least one glycosylated residue." [PRO:DAN]
comment: Category=modification.
synonym: "CD8A/iso:1/SigPep-/GlycoRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00693 ! glycosylated residue
intersection_of: PR:000025406 ! T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form

[Term]
id: PR:F1NXT4
name: uncharacterized protein, CD8A translation product (chicken)
def: "A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of chicken." [PRO:CNA]
comment: Category=organism-gene.
synonym: "chick-CD8A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:F1NXT4
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: has_gene_template CGNC:49868 ! CD8A (chicken)

[Term]
id: PR:P01732
name: T-cell surface glycoprotein CD8 alpha chain (human)
def: "A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of human." [PRO:CNA, UniProtKB:P01732]
comment: Category=organism-gene.
synonym: "MAL" RELATED Gene-based [UniProtKB:P01732]
synonym: "CD8A" RELATED Gene-based [UniProtKB:P01732]
synonym: "hCD8A" EXACT PRO-short-label [PRO:DNx]
synonym: "CD8a (human)" EXACT [UniProtKB:P01732]
synonym: "T-lymphocyte differentiation antigen T8/Leu-2 (human)" EXACT [UniProtKB:P01732]
xref: UniProtKB:P01732
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: has_gene_template HGNC:1706 ! CD8A (human)

[Term]
id: PR:P01732-3
name: T-cell surface glycoprotein CD8 alpha chain isoform h3 (human)
def: "A T-cell surface glycoprotein CD8 alpha chain (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01732-3." [PRO:DNx, UniProtKB:P01732]
comment: Category=organism-sequence.
synonym: "hCD8A/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P01732-3
is_a: PR:P01732 ! T-cell surface glycoprotein CD8 alpha chain (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P01732-2
name: T-cell surface glycoprotein CD8 alpha chain isoform 2 (human)
def: "A T-cell surface glycoprotein CD8 alpha chain isoform 2 that is encoded in the genome of human." [PRO:DAN]
comment: Category=organism-sequence.
synonym: "hCD8A/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "T-cell surface glycoprotein CD8 alpha chain isoform secreted (human)" EXACT [UniProtKB:P01732]
synonym: "T-cell surface glycoprotein CD8 alpha chain isoform sCD8alpha (human)" EXACT [UniProtKB:P01732]
xref: UniProtKB:P01732-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025404 ! T-cell surface glycoprotein CD8 alpha chain isoform 2

[Term]
id: PR:P01732-1
name: T-cell surface glycoprotein CD8 alpha chain isoform 1 (human)
def: "A T-cell surface glycoprotein CD8 alpha chain isoform 1 that is encoded in the genome of human." [PRO:DAN]
comment: Category=organism-sequence.
synonym: "hCD8A/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "T-cell surface glycoprotein CD8 alpha chain isoform membrane (human)" EXACT [UniProtKB:P01732]
synonym: "T-cell surface glycoprotein CD8 alpha chain isoform mCD8alpha (human)" EXACT [UniProtKB:P01732]
xref: UniProtKB:P01732-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025403 ! T-cell surface glycoprotein CD8 alpha chain isoform 1

[Term]
id: PR:P01731
name: T-cell surface glycoprotein CD8 alpha chain (mouse)
def: "A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of mouse." [OMA:P01731, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cd8a" RELATED Gene-based [UniProtKB:P01731]
synonym: "Lyt2" RELATED Gene-based [UniProtKB:P01731]
synonym: "Lyt-2" RELATED Gene-based [UniProtKB:P01731]
synonym: "mCD8A" EXACT PRO-short-label [PRO:DNx]
synonym: "CD8a (mouse)" EXACT [UniProtKB:P01731]
synonym: "T-cell surface glycoprotein Lyt-2 (mouse)" EXACT [UniProtKB:P01731]
xref: UniProtKB:P01731
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: has_gene_template MGI:88346 ! Cd8a (mouse)

[Term]
id: PR:P07725
name: T-cell surface glycoprotein CD8 alpha chain (rat)
def: "A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of rat." [OMA:P07725, PANTHER:PTHR10441:SF1, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cd8a" RELATED Gene-based [UniProtKB:P07725]
synonym: "rCD8A" EXACT PRO-short-label [PRO:DNx]
synonym: "CD8a (rat)" EXACT [UniProtKB:P07725]
synonym: "OX-8 membrane antigen (rat)" RELATED [UniProtKB:P07725]
synonym: "CD8 antigen 32 kDa chain (rat)" EXACT [UniProtKB:P07725]
xref: UniProtKB:P07725
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: has_gene_template RGD:2316 ! Cd8a (rat)

[Term]
id: PR:P01731-1
name: T-cell surface glycoprotein CD8 alpha chain isoform m1 (mouse)
def: "A T-cell surface glycoprotein CD8 alpha chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01731-1." [PRO:DNx, UniProtKB:P01731]
comment: Category=organism-sequence.
synonym: "mCD8A/iso:m1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P01731-1
is_a: PR:P01731 ! T-cell surface glycoprotein CD8 alpha chain (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000001084
name: T-cell surface glycoprotein CD8 alpha chain
def: "A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain." [PMID:11114424, PRO:CNA, Wikipedia:CD8]
comment: Category=gene. Requested by=CL.
synonym: "MAL" RELATED Gene-based []
synonym: "CD8A" EXACT PRO-short-label [PRO:DNx]
synonym: "CD8a" EXACT []
synonym: "Lyt2" RELATED Gene-based []
synonym: "Lyt-2" RELATED Gene-based []
synonym: "T-cell surface glycoprotein Lyt-2" EXACT []
synonym: "T-lymphocyte differentiation antigen T8/Leu-2" EXACT []
xref: PANTHER:PTHR10441:SF1
is_a: PR:000000001 ! protein