[Term]
id: PR:P26361
name: cystic fibrosis transmembrane conductance regulator (mouse)
def: "A cystic fibrosis transmembrane conductance regulator that is encoded in the genome of mouse." [OMA:P26361, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cftr" RELATED Gene-based [UniProtKB:P26361]
synonym: "Abcc7" RELATED Gene-based [UniProtKB:P26361]
synonym: "mCFTR" EXACT PRO-short-label [PRO:DNx]
synonym: "CFTR (mouse)" EXACT [UniProtKB:P26361]
synonym: "cAMP-dependent chloride channel (mouse)" EXACT [UniProtKB:P26361]
synonym: "channel conductance-controlling ATPase (mouse)" EXACT [UniProtKB:P26361]
synonym: "ATP-binding cassette sub-family C member 7 (mouse)" EXACT [UniProtKB:P26361]
xref: UniProtKB:P26361
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001044 ! cystic fibrosis transmembrane conductance regulator
relationship: has_gene_template MGI:88388 ! Cftr (mouse)

[Term]
id: PR:000001044
name: cystic fibrosis transmembrane conductance regulator
def: "A chloride channel protein that is a translation product of the human CFTR gene or a 1:1 ortholog thereof. Involved in the transport of chloride ions. The characteristic domain composition of the functional isoform consists of two modules of a membrane-spanning domain (ABC transporter transmembrane region) followed by a nucleotide-binding domain (ABC transporter domains), separated by an intracellular regulatory domain (R-domain). It also contains a C-terminal PDZ-binding region. The R-domain is an inhibitory domain of CFTR, and phosphorylation of the R-domain removes this inhibition, allowing activation of chloride flux." [PMID:9922375, PRO:CNA]
comment: Category=gene. Note: The open conformation of the CFTR channel is stabilized via interaction of its N-terminal region with other proteins, most notably filamin. [PRO:DAN, PMID:29779042]
synonym: "CFTR" EXACT PRO-short-label [PRO:DNx]
synonym: "ABCC7" RELATED Gene-based []
synonym: "cAMP-dependent chloride channel" EXACT []
synonym: "channel conductance-controlling ATPase" EXACT []
synonym: "ATP-binding cassette sub-family C member 7" EXACT []
synonym: "ATP-binding cassette transporter sub-family C member 7" EXACT []
xref: IUPHARobj:707
xref: PIRSF:PIRSF002777
is_a: PR:000044678 ! chloride channel protein

[Term]
id: PR:P26361-1
name: cystic fibrosis transmembrane conductance regulator isoform 1 (mouse)
def: "A cftr isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mCFTR/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P26361-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001045 ! cftr isoform 1

[Term]
id: PR:P26361-2
name: cystic fibrosis transmembrane conductance regulator isoform m2 (mouse)
def: "A cystic fibrosis transmembrane conductance regulator (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P26361-2." [PRO:DNx, UniProtKB:P26361]
comment: Category=organism-sequence.
synonym: "mCFTR/iso:m2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P26361-2
is_a: PR:P26361 ! cystic fibrosis transmembrane conductance regulator (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P26361-3
name: cystic fibrosis transmembrane conductance regulator isoform m3 (mouse)
def: "A cystic fibrosis transmembrane conductance regulator (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P26361-3." [PRO:DNx, UniProtKB:P26361]
comment: Category=organism-sequence.
synonym: "mCFTR/iso:m3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P26361-3
is_a: PR:P26361 ! cystic fibrosis transmembrane conductance regulator (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus