[Term]
id: PR:O14745-2
name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform h2 (human)
def: "A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14745-2." [PRO:DNx, UniProtKB:O14745]
comment: Category=organism-sequence.
synonym: "hSLC9A3R1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O14745-2
is_a: PR:O14745 ! Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O14745
name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (human)
def: "A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O14745]
comment: Category=organism-gene.
synonym: "NHERF" RELATED Gene-based [UniProtKB:O14745]
synonym: "NHERF1" RELATED Gene-based [UniProtKB:O14745]
synonym: "SLC9A3R1" RELATED Gene-based [UniProtKB:O14745]
synonym: "hSLC9A3R1" EXACT PRO-short-label [PRO:DNx]
synonym: "EBP50 (human)" EXACT [UniProtKB:O14745]
synonym: "NHERF-1 (human)" EXACT [UniProtKB:O14745]
synonym: "regulatory cofactor of Na(+)/H(+) exchanger (human)" EXACT [UniProtKB:O14745]
synonym: "sodium-hydrogen exchanger regulatory factor 1 (human)" EXACT [UniProtKB:O14745]
synonym: "ezrin-radixin-moesin-binding phosphoprotein 50 (human)" EXACT [UniProtKB:O14745]
synonym: "solute carrier family 9 isoform A3 regulatory factor 1 (human)" EXACT [UniProtKB:O14745]
xref: UniProtKB:O14745
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001041 ! Na(+)/H(+) exchange regulatory cofactor NHE-RF1
relationship: has_gene_template HGNC:11075 ! SLC9A3R1 (human)

[Term]
id: PR:000001041
name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1
def: "A Na(+)/H(+) exchange regulatory cofactor with ERM-binding domain that is a translation product of the human SLC9A3R1 gene or a 1:1 ortholog thereof. It contains two copies of the PDZ domain at the N terminus and an EBP50 domain at the C-terminus. The latter allows interaction with FERM domains, resulting in the activation of ERM proteins (PR:000001030), with subsequent cytoskeletal modulation and cellular growth control." [PRO:CNA]
comment: Category=gene.
synonym: "EBP50" EXACT []
synonym: "NHERF" RELATED Gene-based []
synonym: "NHERF1" RELATED Gene-based []
synonym: "NHERF-1" EXACT []
synonym: "SLC9A3R1" EXACT PRO-short-label [PRO:DNx]
synonym: "regulatory cofactor of Na(+)/H(+) exchanger" EXACT []
synonym: "sodium-hydrogen exchanger regulatory factor 1" EXACT []
synonym: "ezrin-radixin-moesin-binding phosphoprotein 50" EXACT []
synonym: "solute carrier family 9 isoform A3 regulatory factor 1" EXACT []
is_a: PR:000001043 ! Na(+)/H(+) exchange regulatory cofactor with ERM-binding domain

[Term]
id: PR:O14745-1
name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 (human)
def: "A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSLC9A3R1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O14745-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001042 ! Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1