[Term]
id: PR:P31977-1
name: ezrin isoform 1 (rat)
def: "An ezrin isoform 1 that is encoded in the genome of rat." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "rEZR/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P31977-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000001032 ! ezrin isoform 1

[Term]
id: PR:000036592
name: ezrin isoform 1 phosphorylated 5 (human)
def: "An ezrin isoform 1 phosphorylated 5 in human. UniProtKB:P15311-1, Thr-567, MOD:00047." [PMID:16144865, PMID:18025306, PRO:AL, PRO:CNA]
comment: Category=organism-modification.
synonym: "hEZR/iso:1/Phos:5" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P15311-1, Thr-567, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001040 ! ezrin isoform 1 phosphorylated 5
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000036591
name: ezrin isoform 1 phosphorylated 4 (human)
def: "An ezrin isoform 1 phosphorylated 4 in human. UniProtKB:P15311-1, Tyr-146/Tyr-191, MOD:00048|Thr-567, MOD:00047." [PMID:15647376, PRO:CNA]
comment: Category=organism-modification.
synonym: "hEZR/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P15311-1, Tyr-146/Tyr-191, MOD:00048|Thr-567, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001039 ! ezrin isoform 1 phosphorylated 4
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000036590
name: ezrin isoform 1 phosphorylated 3 (human)
def: "An ezrin isoform 1 phosphorylated 3 in human. UniProtKB:P15311-1, Tyr-191, MOD:00048." [PMID:15647376, PRO:CNA]
comment: Category=organism-modification.
synonym: "hEZR/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P15311-1, Tyr-191, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001038 ! ezrin isoform 1 phosphorylated 3
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:P46150-5
name: moesin/ezrin/radixin homolog 1 isoform C (fruit fly)
def: "A moesin/ezrin/radixin homolog 1 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46150-5." [PRO:DNx, UniProtKB:P46150]
comment: Category=organism-sequence.
synonym: "fly-EZR/iso:C" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P46150-5
is_a: PR:P46150 ! moesin/ezrin/radixin homolog 1 (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:000003042
name: ezrin isoform 1 phosphorylated 6
def: "An ezrin isoform 1 phosphorylated form in which the phosphorylation occurs at either the C-terminal Thr (Thr-567 in human), through kinases such as Rho-kinase, or the N-terminal tyrosine residue (Tyr-354 in human). Example: UniProtKB:P15311-1, Tyr-354, MOD:00048|Thr-567, MOD:00047." [PMID:18852256, PRO:AL]
comment: Category=modification.
synonym: "EZR/iso:1/Phos:6" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001033 ! ezrin isoform 1 phosphorylated form
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000047346
name: ezrin, initiator methionine removed phosphorylated 1 (human)
def: "An ezrin (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at positions 146 and 354 of the amino acid sequence represented by UniProtKB:P15311. UniProtKB:P15311, 2-586, Tyr-146/Tyr-354, MOD:00048." [PRO:DNx, Reactome:R-HSA-374572]
comment: Category=organism-modification.
synonym: "hEZR/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000219408, Tyr-146/Tyr-354, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P15311, 2-586, Tyr-146/Tyr-354, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-374572 "PR:000047346 located_in GO:0005829"
is_a: PR:P15311 ! ezrin (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000047345
name: ezrin, initiator methionine removed phosphorylated 5 (human)
def: "An ezrin (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 567 of the amino acid sequence represented by UniProtKB:P15311. UniProtKB:P15311, 2-586, Thr-567, MOD:00047." [PRO:DNx, Reactome:R-HSA-374559]
comment: Category=organism-modification.
synonym: "hEZR/InitMet-/Phos:5" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000219408, Thr-567, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P15311, 2-586, Thr-567, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-374559 "PR:000047345 located_in GO:0005829"
is_a: PR:P15311 ! ezrin (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000001040
name: ezrin isoform 1 phosphorylated 5
def: "An ezrin isoform 1 phosphorylated form in which the phosphorylation occurs at a Thr residue located within the C-terminal domain. Example: UniProtKB:P15311-1, Thr-567, MOD:00047." [PMID:16144865]
comment: Category=modification.
synonym: "EZR/iso:1/Phos:5" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001033 ! ezrin isoform 1 phosphorylated form
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:P46150-1
name: moesin/ezrin/radixin homolog 1 isoform J (fruit fly)
def: "A moesin/ezrin/radixin homolog 1 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46150-1." [PRO:DNx, UniProtKB:P46150]
comment: Category=organism-sequence.
synonym: "fly-EZR/iso:J" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P46150-1
is_a: PR:P46150 ! moesin/ezrin/radixin homolog 1 (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:P46150-2
name: moesin/ezrin/radixin homolog 1 isoform D (fruit fly)
def: "A moesin/ezrin/radixin homolog 1 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46150-2." [PRO:DNx, UniProtKB:P46150]
comment: Category=organism-sequence.
synonym: "fly-EZR/iso:D" EXACT PRO-short-label [PRO:DNx]
synonym: "moesin/ezrin/radixin homolog 1 isoform E (fruit fly)" EXACT [UniProtKB:P46150]
synonym: "moesin/ezrin/radixin homolog 1 isoform F (fruit fly)" EXACT [UniProtKB:P46150]
synonym: "moesin/ezrin/radixin homolog 1 isoform G (fruit fly)" EXACT [UniProtKB:P46150]
synonym: "moesin/ezrin/radixin homolog 1 isoform H (fruit fly)" EXACT [UniProtKB:P46150]
synonym: "moesin/ezrin/radixin homolog 1 isoform I (fruit fly)" EXACT [UniProtKB:P46150]
xref: UniProtKB:P46150-2
is_a: PR:P46150 ! moesin/ezrin/radixin homolog 1 (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:P46150-3
name: moesin/ezrin/radixin homolog 1 isoform A (fruit fly)
def: "A moesin/ezrin/radixin homolog 1 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46150-3." [PRO:DNx, UniProtKB:P46150]
comment: Category=organism-sequence.
synonym: "fly-EZR/iso:A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P46150-3
is_a: PR:P46150 ! moesin/ezrin/radixin homolog 1 (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:P46150-4
name: moesin/ezrin/radixin homolog 1 isoform B (fruit fly)
def: "A moesin/ezrin/radixin homolog 1 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46150-4." [PRO:DNx, UniProtKB:P46150]
comment: Category=organism-sequence.
synonym: "fly-EZR/iso:B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P46150-4
is_a: PR:P46150 ! moesin/ezrin/radixin homolog 1 (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:P26040-1
name: ezrin isoform 1 (mouse)
def: "An ezrin isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mEZR/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P26040-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001032 ! ezrin isoform 1

[Term]
id: PR:000018330
name: ezrin, initiator methionine removed form
def: "An ezrin that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "EZR/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000001031 ! ezrin
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000036588
name: ezrin isoform 1 phosphorylated 1 (human)
def: "An ezrin isoform 1 phosphorylated 1 in human. UniProtKB:P15311-1, Tyr-146/Tyr-354, MOD:00048." [PMID:1382070, PRO:CNA]
comment: Category=organism-modification.
synonym: "hEZR/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P15311-1, Tyr-146/Tyr-354, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001034 ! ezrin isoform 1 phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000036589
name: ezrin isoform 1 phosphorylated 2 (human)
def: "An ezrin isoform 1 phosphorylated 2 in human. UniProtKB:P15311-1, Ser-66, MOD:00046." [PMID:12840026, PMID:16438931, PRO:CNA]
comment: Category=organism-modification.
synonym: "hEZR/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P15311-1, Ser-66, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001035 ! ezrin isoform 1 phosphorylated 2
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000036625
name: ezrin isoform 1 phosphorylated 6 (human)
def: "An ezrin isoform 1 phosphorylated 6 in human. UniProtKB:P15311-1, Tyr-354, MOD:00048|Thr-567, MOD:00047." [PMID:18852256, PRO:AL]
comment: Category=organism-modification.
synonym: "hEZR/iso:1/Phos:6" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P15311-1, Tyr-354, MOD:00048|Thr-567, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003042 ! ezrin isoform 1 phosphorylated 6
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:P31977
name: ezrin (rat)
def: "An ezrin that is encoded in the genome of rat." [OMA:P31977, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ezr" RELATED Gene-based [UniProtKB:P31977]
synonym: "Vil2" RELATED Gene-based [UniProtKB:P31977]
synonym: "rEZR" EXACT PRO-short-label [PRO:DNx]
synonym: "p81 (rat)" BROAD [UniProtKB:P31977]
synonym: "villin-2 (rat)" EXACT [UniProtKB:P31977]
synonym: "cytovillin (rat)" EXACT [UniProtKB:P31977]
xref: UniProtKB:P31977
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000001031 ! ezrin
relationship: has_gene_template RGD:621161 ! Ezr (rat)

[Term]
id: PR:P26040
name: ezrin (mouse)
def: "An ezrin that is encoded in the genome of mouse." [OMA:P26040, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ezr" RELATED Gene-based [UniProtKB:P26040]
synonym: "Vil2" RELATED Gene-based [UniProtKB:P26040]
synonym: "mEZR" EXACT PRO-short-label [PRO:DNx]
synonym: "p81 (mouse)" BROAD [UniProtKB:P26040]
synonym: "villin-2 (mouse)" EXACT [UniProtKB:P26040]
synonym: "cytovillin (mouse)" EXACT [UniProtKB:P26040]
xref: UniProtKB:P26040
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001031 ! ezrin
relationship: has_gene_template MGI:98931 ! Ezr (mouse)

[Term]
id: PR:P46150
name: moesin/ezrin/radixin homolog 1 (fruit fly)
def: "An ezrin that is encoded in the genome of fruit fly." [PRO:CNA]
comment: Category=organism-gene.
synonym: "Moe" RELATED Gene-based [UniProtKB:P46150]
synonym: "EMR1" RELATED Gene-based [UniProtKB:P46150]
synonym: "CG10701" RELATED Gene-based [UniProtKB:P46150]
synonym: "dMoesin" EXACT [UniProtKB:P46150]
synonym: "fly-EZR" EXACT PRO-short-label [PRO:DNx]
synonym: "moesin (fruit fly)" EXACT [UniProtKB:P46150]
synonym: "protein D17 (fruit fly)" EXACT [UniProtKB:P46150]
synonym: "ezrin-moesin-radixin 1 (fruit fly)" EXACT [UniProtKB:P46150]
xref: UniProtKB:P46150
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000001031 ! ezrin
relationship: has_gene_template FlyBase:FBgn0011661 ! Moe (fruit fly)

[Term]
id: PR:000001038
name: ezrin isoform 1 phosphorylated 3
def: "An ezrin isoform 1 phosphorylated form in which the phosphorylation occurs at the first Tyr residue within the ITAM-like motif EYLKIAQDLEMYGINYFEI. Example: UniProtKB:P15311-1, Tyr-191, MOD:00048." [PMID:15647376, PMID:9052872]
comment: Category=modification.
synonym: "EZR/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001033 ! ezrin isoform 1 phosphorylated form
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000001039
name: ezrin isoform 1 phosphorylated 4
def: "An ezrin isoform 1 phosphorylated form in which the phosphorylation occurs both in a Tyr residue within the FERM central domain, and the first Tyr residue within the ITAM-like motif EYLKIAQDLEMYGINYFEI. Example: UniProtKB:P15311-1, Tyr-146/Tyr-191, MOD:00048|Thr-567, MOD:00047." [PMID:15647376]
comment: Category=modification.
synonym: "EZR/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001033 ! ezrin isoform 1 phosphorylated form
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000001034
name: ezrin isoform 1 phosphorylated 1
def: "An ezrin isoform 1 phosphorylated form in which the phosphorylation occurs upon EGF stimulation. Example: UniProtKB:P15311-1, Tyr-146/Tyr-354, MOD:00048." [PMID:1382070]
comment: Category=modification.
synonym: "EZR/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001033 ! ezrin isoform 1 phosphorylated form
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000001035
name: ezrin isoform 1 phosphorylated 2
def: "An ezrin isoform 1 phosphorylated form in which the phosphorylation occurs by the action of protein kinase A (PKA). Example: UniProtKB:P15311-1, Ser-66, MOD:00046." [PMID:12840026, PMID:16438931, PhosphoSitePlus:28933]
comment: Category=modification.
synonym: "EZR/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001033 ! ezrin isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000001032
name: ezrin isoform 1
def: "An ezrin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15311-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "EZR/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001031 ! ezrin

[Term]
id: PR:000001033
name: ezrin isoform 1 phosphorylated form
def: "An ezrin isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "EZR/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000001032 ! ezrin isoform 1

[Term]
id: PR:P15311-1
name: ezrin isoform 1 (human)
def: "An ezrin isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hEZR/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P15311-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001032 ! ezrin isoform 1

[Term]
id: PR:000001031
name: ezrin
def: "An erm protein that is a translation product of the human EZR gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "EZR" EXACT PRO-short-label [PRO:DNx]
synonym: "p81" BROAD [PRO:DNx]
synonym: "VIL2" RELATED Gene-based []
synonym: "villin-2" EXACT []
synonym: "cytovillin" EXACT []
is_a: PR:000001030 ! erm protein

[Term]
id: PR:P15311
name: ezrin (human)
def: "An ezrin that is encoded in the genome of human." [PRO:CNA, UniProtKB:P15311]
comment: Category=organism-gene.
synonym: "EZR" RELATED Gene-based [UniProtKB:P15311]
synonym: "VIL2" RELATED Gene-based [UniProtKB:P15311]
synonym: "hEZR" EXACT PRO-short-label [PRO:DNx]
synonym: "p81 (human)" BROAD [UniProtKB:P15311]
synonym: "villin-2 (human)" EXACT [UniProtKB:P15311]
synonym: "cytovillin (human)" EXACT [UniProtKB:P15311]
xref: Reactome:R-HSA-9020826 "PR:P15311 located_in GO:0005829"
xref: UniProtKB:P15311
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001031 ! ezrin
relationship: has_gene_template HGNC:12691 ! EZR (human)

[Term]
id: PR:000044790
name: ezrin isoform 1 phosphorylated 5 (mouse)
def: "An ezrin isoform 1 phosphorylated 5 in mouse. UniProtKB:P26040-1, Thr-567, MOD:00047." [PRO:DAN]
comment: Category=organism-modification.
synonym: "mEZR/iso:1/Phos:5" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P26040-1, Thr-567, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001040 ! ezrin isoform 1 phosphorylated 5
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000026720
name: ezrin isoform 1, initiator methionine removed form
def: "An ezrin isoform 1 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "EZR/iso:1/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000001032 ! ezrin isoform 1
intersection_of: lacks_part PR:000021937 ! initiator methionine