[Term]
id: PR:000001006
name: receptor-type tyrosine-protein phosphatase C
def: "A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule." [PMID:1351092, PRO:CNA]
comment: Category=gene. Requested by=CL.
synonym: "CD45" RELATED Gene-based []
synonym: "L-CA" EXACT []
synonym: "T200" BROAD [PRO:DNx]
synonym: "ly-5" EXACT []
synonym: "PTPRC" EXACT PRO-short-label [PRO:DNx]
synonym: "lymphocyte antigen 5" EXACT []
synonym: "leukocyte common antigen" EXACT []
xref: IUPHARobj:1852
xref: PIRSF:PIRSF002004
is_a: PR:000000001 ! protein