[Term]
id: PR:P08575-9
name: receptor-type tyrosine-protein phosphatase C isoform CD45RB (human)
def: "A receptor-type tyrosine-protein phosphatase C isoform CD45RB that is encoded in the genome of human." [GOC:add, PRO:ADD, PRO:DAN]
comment: Category=organism-sequence.
synonym: "CD45RB (human)" EXACT [UniProtKB:P08575]
synonym: "hPTPRC/iso:CD45RB" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P08575-9
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001016 ! receptor-type tyrosine-protein phosphatase C isoform CD45RB

[Term]
id: PR:P08575-8
name: receptor-type tyrosine-protein phosphatase C isoform CD45RA (human)
def: "A receptor-type tyrosine-protein phosphatase C isoform CD45RA that is encoded in the genome of human." [GOC:add, PRO:ADD, PRO:DAN]
comment: Category=organism-sequence. Requested by=CL.
synonym: "CD45RA (human)" EXACT []
synonym: "hPTPRC/iso:CD45RA" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P08575-8
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA

[Term]
id: PR:P08575-3
name: receptor-type tyrosine-protein phosphatase C isoform CD45RABC (human)
def: "A receptor-type tyrosine-protein phosphatase C isoform CD45RABC that is encoded in the genome of human." [PRO:DAN]
comment: Category=organism-sequence.
synonym: "hPTPRC/iso:CD45RABC" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P08575-3
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45RABC

[Term]
id: PR:P08575-5
name: receptor-type tyrosine-protein phosphatase C isoform CD45RAB (human)
def: "A receptor-type tyrosine-protein phosphatase C isoform CD45RAB that is encoded in the genome of human." [PRO:DNx, UniProtKB:P08575]
comment: Category=organism-sequence.
synonym: "CD45RAB (human)" EXACT [PRO:ADD, GOC:add]
synonym: "hPTPRC/iso:CD45RAB" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P08575-5
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025802 ! receptor-type tyrosine-protein phosphatase C isoform CD45RAB

[Term]
id: PR:P08575-4
name: receptor-type tyrosine-protein phosphatase C isoform CD45RO (human)
def: "A receptor-type tyrosine-protein phosphatase C isoform CD45RO that is encoded in the genome of human." [GOC:add, PRO:ADD, PRO:DAN]
comment: Category=organism-sequence.
synonym: "CD45RO (human)" EXACT [PRO:ADD, GOC:add]
synonym: "hPTPRC/iso:CD45RO" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P08575-4
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO

[Term]
id: PR:P08575-7
name: receptor-type tyrosine-protein phosphatase C isoform CD45RBC (human)
def: "A receptor-type tyrosine-protein phosphatase C isoform CD45RBC that is encoded in the genome of human." [PRO:DNx, UniProtKB:P08575]
comment: Category=organism-sequence.
synonym: "CD45RBC (human)" EXACT [UniProtKB:P08575]
synonym: "hPTPRC/iso:CD45RBC" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P08575-7
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025804 ! receptor-type tyrosine-protein phosphatase C isoform CD45RBC

[Term]
id: PR:P08575-6
name: receptor-type tyrosine-protein phosphatase C isoform CD45RAC (human)
def: "A receptor-type tyrosine-protein phosphatase C isoform CD45RAC that is encoded in the genome of human." [PRO:DNx, UniProtKB:P08575]
comment: Category=organism-sequence.
synonym: "CD45RAC (human)" EXACT [PRO:ADD, GOC:add]
synonym: "hPTPRC/iso:CD45RAC" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P08575-6
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025803 ! receptor-type tyrosine-protein phosphatase C isoform CD45RAC

[Term]
id: PR:P08575
name: receptor-type tyrosine-protein phosphatase C (human)
def: "A receptor-type tyrosine-protein phosphatase C that is encoded in the genome of human." [PRO:CNA, UniProtKB:P08575]
comment: Category=organism-gene.
synonym: "CD45" RELATED Gene-based [UniProtKB:P08575]
synonym: "PTPRC" RELATED Gene-based [UniProtKB:P08575]
synonym: "hPTPRC" EXACT PRO-short-label [PRO:DNx]
synonym: "L-CA (human)" EXACT [UniProtKB:P08575]
synonym: "T200 (human)" EXACT [UniProtKB:P08575]
synonym: "leukocyte common antigen (human)" EXACT [UniProtKB:P08575]
xref: UniProtKB:P08575
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001006 ! receptor-type tyrosine-protein phosphatase C
relationship: has_gene_template HGNC:9666 ! PTPRC (human)

[Term]
id: PR:000048962
name: receptor-type tyrosine-protein phosphatase C, signal peptide removed form (human)
def: "A receptor-type tyrosine-protein phosphatase C (human) that has had the signal peptide removed. UniProtKB:P08575, 24-1304." [PRO:DNx, Reactome:R-HSA-197931]
comment: Category=organism-modification.
synonym: "PRO_0000025470" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hPTPRC/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P08575, 24-1304" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-197931 "PR:000048962 located_in GO:0005886"
xref: Reactome:R-HSA-6806150 "PR:000048962 located_in GO:0030667"
intersection_of: PR:P08575 ! receptor-type tyrosine-protein phosphatase C (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000001006
name: receptor-type tyrosine-protein phosphatase C
def: "A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule." [PMID:1351092, PRO:CNA]
comment: Category=gene. Requested by=CL.
synonym: "CD45" RELATED Gene-based []
synonym: "L-CA" EXACT []
synonym: "T200" BROAD [PRO:DNx]
synonym: "ly-5" EXACT []
synonym: "PTPRC" EXACT PRO-short-label [PRO:DNx]
synonym: "lymphocyte antigen 5" EXACT []
synonym: "leukocyte common antigen" EXACT []
xref: IUPHARobj:1852
xref: PIRSF:PIRSF002004
is_a: PR:000000001 ! protein

[Term]
id: PR:000054485
name: receptor-type tyrosine-protein phosphatase C O-glycosylated 2 (human)
def: "A receptor-type tyrosine-protein phosphatase C (human) that has been O-glycosylated at the residue equivalent to Thr-167 of the amino acid sequence represented by UniProtKB:P08575-3, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P08575-3, Thr-167, MOD:00005~GNO:G53434XO." [GlyGen:P08575-3, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hPTPRC/OGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P08575-3, Thr-167, MOD:00005~GNO:G53434XO" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P08575 ! receptor-type tyrosine-protein phosphatase C (human)
relationship: has_part GNO:G53434XO ! G53434XO
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000054484
name: receptor-type tyrosine-protein phosphatase C O-glycosylated 1 (human)
def: "A receptor-type tyrosine-protein phosphatase C (human) that has been O-glycosylated at the residue equivalent to Ser-176 of the amino acid sequence represented by UniProtKB:P08575-3, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08575-3, Ser-176, MOD:00002~GNO:G43417UB." [GlyGen:P08575-3, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hPTPRC/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P08575-3, Ser-176, MOD:00002~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P08575 ! receptor-type tyrosine-protein phosphatase C (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000054486
name: receptor-type tyrosine-protein phosphatase C O-glycosylated 3 (human)
def: "A receptor-type tyrosine-protein phosphatase C (human) that has been O-glycosylated at the residue equivalent to Thr-167 of the amino acid sequence represented by UniProtKB:P08575-3, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P08575-3, Thr-167, MOD:00005~GNO:G58001LT." [GlyGen:P08575-3, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hPTPRC/OGlyco:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P08575-3, Thr-167, MOD:00005~GNO:G58001LT" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P08575 ! receptor-type tyrosine-protein phosphatase C (human)
relationship: has_part GNO:G58001LT ! G58001LT
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P08575-10
name: receptor-type tyrosine-protein phosphatase C isoform CD45RC (human)
def: "A receptor-type tyrosine-protein phosphatase C isoform CD45RC that is encoded in the genome of human." [PRO:DAN, UniProtKB:P08575]
comment: Category=organism-sequence.
synonym: "CD45RC (human)" EXACT [PRO:ADD, GOC:add]
synonym: "hPTPRC/iso:CD45RC" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P08575-10
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025801 ! receptor-type tyrosine-protein phosphatase C isoform CD45RC