[Term]
id: PR:000000812
name: voltage-gated potassium channel subunit KCNA5
def: "A shaker-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCNA5 gene or a 1:1 ortholog thereof. The voltage-gated potassium channel Kv1.5 mediates the ultrarapid-activating potassium current (IKur) in heart, and also plays a critical role in the regulation of arterial tone." [PMID:10575199, PMID:16772329, PMID:18344374]
comment: Category=gene.
synonym: "HPCN1" EXACT []
synonym: "KCNA5" EXACT PRO-short-label [PRO:DNx]
synonym: "KV1-5" EXACT []
synonym: "voltage-gated potassium channel HK2" EXACT []
synonym: "voltage-gated potassium channel subunit Kv1.5" EXACT []
xref: IUPHARobj:542
xref: PANTHER:PTHR11537:SF25
is_a: PR:000000709 ! shaker-related voltage-gated potassium channel alpha subunit

[Term]
id: PR:000036568
name: potassium voltage-gated channel subfamily A member 5 isoform 1 sequence variant E375* (human)
def: "A potassium voltage-gated channel subfamily A member 5 isoform 1 (human) that has a C-terminal truncation and thus lacks the S4-S6 voltage sensor, pore region and C terminus, but preserves the N terminus and S1-S3 transmembrane domains that secure tetrameric subunit assembly. UniProtKB:P22460-1, 1-374." [PMID:16772329, PRO:CNA]
comment: Category=organism-sequence.
synonym: "hKCNA5/iso:1/var:E375*" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P22460-1, 1-374" EXACT PRO-proteoform-std [PRO:DAN]
is_a: PR:P22460-1 ! potassium voltage-gated channel subfamily A member 5 isoform 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P22460-1
name: potassium voltage-gated channel subfamily A member 5 isoform 1 (human)
def: "A voltage-gated potassium channel subunit KCNA5 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hKCNA5/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P22460-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000974 ! voltage-gated potassium channel subunit KCNA5 isoform 1

[Term]
id: PR:P22460-2
name: potassium voltage-gated channel subfamily A member 5 isoform h2 (human)
def: "A potassium voltage-gated channel subfamily A member 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22460-2." [PRO:DNx, UniProtKB:P22460]
comment: Category=organism-sequence.
synonym: "hKCNA5/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "potassium voltage-gated channel subfamily A member 5 isoform Short (human)" EXACT [UniProtKB:P22460]
xref: UniProtKB:P22460-2
is_a: PR:P22460 ! potassium voltage-gated channel subfamily A member 5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P22460
name: potassium voltage-gated channel subfamily A member 5 (human)
def: "A voltage-gated potassium channel subunit KCNA5 that is encoded in the genome of human." []
comment: Category=organism-gene.
synonym: "KCNA5" RELATED Gene-based [UniProtKB:P22460]
synonym: "hKCNA5" EXACT PRO-short-label [PRO:DNx]
synonym: "HPCN1 (human)" EXACT [UniProtKB:P22460]
synonym: "voltage-gated potassium channel HK2 (human)" EXACT [UniProtKB:P22460]
synonym: "voltage-gated potassium channel subunit Kv1.5 (human)" EXACT [UniProtKB:P22460]
xref: Reactome:R-HSA-977472 "PR:P22460 located_in GO:0005886"
xref: DTO:01100184
xref: UniProtKB:P22460
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000812 ! voltage-gated potassium channel subunit KCNA5
relationship: has_gene_template HGNC:6224 ! KCNA5 (human)