[Term]
id: PR:O35219
name: potassium voltage-gated channel subfamily H member 2 (mouse)
def: "A voltage-gated potassium channel KCNH2 that is encoded in the genome of mouse." [OMA:O35219, PRO:DNx]
comment: Category=organism-gene.
synonym: "Erg" RELATED Gene-based [UniProtKB:O35219]
synonym: "Kcnh2" RELATED Gene-based [UniProtKB:O35219]
synonym: "Merg1" RELATED Gene-based [UniProtKB:O35219]
synonym: "mKCNH2" EXACT PRO-short-label [PRO:DNx]
synonym: "MERG (mouse)" EXACT [UniProtKB:O35219]
synonym: "ERG-1 (mouse)" EXACT [UniProtKB:O35219]
synonym: "Eag-related protein 1 (mouse)" EXACT [UniProtKB:O35219]
synonym: "ether-a-go-go-related protein 1 (mouse)" EXACT [UniProtKB:O35219]
synonym: "ether-a-go-go-related gene potassium channel 1 (mouse)" EXACT [UniProtKB:O35219]
synonym: "voltage-gated potassium channel subunit Kv11.1 (mouse)" EXACT [UniProtKB:O35219]
xref: UniProtKB:O35219
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000791 ! voltage-gated potassium channel KCNH2
relationship: has_gene_template MGI:1341722 ! Kcnh2 (mouse)

[Term]
id: PR:000000989
name: voltage-gated potassium channel KCNH2 isoform A glycosylated form
def: "A voltage-gated potassium channel KCNH2 isoform A that includes at least one glycosylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "KCNH2/iso:1/GlycoRes+" EXACT [PRO:DNx]
synonym: "KCNH2/iso:A/GlycoRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00693 ! glycosylated residue
intersection_of: PR:000000957 ! voltage-gated potassium channel KCNH2 isoform A

[Term]
id: PR:000000791
name: voltage-gated potassium channel KCNH2
def: "A voltage-gated potassium channel Erg alpha subunit that is a translation product of the human KCNH2 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "ERG" RELATED Gene-based []
synonym: "ERG1" RELATED Gene-based []
synonym: "HERG" RELATED Gene-based []
synonym: "ERG-1" EXACT []
synonym: "KCNH2" EXACT PRO-short-label [PRO:DNx]
synonym: "KHCN2" RELATED [PRO:CNA]
synonym: "Eag homolog" EXACT []
synonym: "Eag-related protein 1" EXACT []
synonym: "ether-a-go-go-related protein 1" EXACT []
synonym: "ether-a-go-go-related gene potassium channel 1" EXACT []
synonym: "voltage-gated potassium channel subunit Kv11.1" EXACT []
xref: IUPHARobj:572
is_a: PR:000000721 ! voltage-gated potassium channel Erg alpha subunit

[Term]
id: PR:O08962
name: potassium voltage-gated channel subfamily H member 2 (rat)
def: "A voltage-gated potassium channel KCNH2 that is encoded in the genome of rat." [OMA:O08962, PANTHER:PTHR10217:SF382, PRO:DNx]
comment: Category=organism-gene.
synonym: "Erg" RELATED Gene-based [UniProtKB:O08962]
synonym: "Kcnh2" RELATED Gene-based [UniProtKB:O08962]
synonym: "r-ERG" EXACT [UniProtKB:O08962]
synonym: "rKCNH2" EXACT PRO-short-label [PRO:DNx]
synonym: "RERG (rat)" EXACT [UniProtKB:O08962]
synonym: "ERG-1 (rat)" EXACT [UniProtKB:O08962]
synonym: "Eag-related protein 1 (rat)" EXACT [UniProtKB:O08962]
synonym: "ether-a-go-go-related protein 1 (rat)" EXACT [UniProtKB:O08962]
synonym: "ether-a-go-go-related gene potassium channel 1 (rat)" EXACT [UniProtKB:O08962]
synonym: "voltage-gated potassium channel subunit Kv11.1 (rat)" EXACT [UniProtKB:O08962]
xref: UniProtKB:O08962
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000791 ! voltage-gated potassium channel KCNH2
relationship: has_gene_template RGD:621414 ! Kcnh2 (rat)

[Term]
id: PR:Q12809-1
name: potassium voltage-gated channel subfamily H member 2 isoform A (human)
def: "A voltage-gated potassium channel KCNH2 isoform A that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hKCNH2/iso:A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q12809-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000957 ! voltage-gated potassium channel KCNH2 isoform A

[Term]
id: PR:Q12809-2
name: potassium voltage-gated channel subfamily H member 2 isoform B (human)
def: "A voltage-gated potassium channel KCNH2 isoform B that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q12809]
comment: Category=organism-sequence.
synonym: "hKCNH2/iso:B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q12809-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000958 ! voltage-gated potassium channel KCNH2 isoform B

[Term]
id: PR:Q12809-5
name: potassium voltage-gated channel subfamily H member 2 isoform A-USO (human)
def: "A voltage-gated potassium channel KCNH2 isoform A-USO that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q12809]
comment: Category=organism-sequence.
synonym: "hKCNH2/iso:A-USO" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q12809-5
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000959 ! voltage-gated potassium channel KCNH2 isoform A-USO

[Term]
id: PR:O35219-3
name: potassium voltage-gated channel subfamily H member 2 isoform B (mouse)
def: "A voltage-gated potassium channel KCNH2 isoform B that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:O35219]
comment: Category=organism-sequence.
synonym: "mKCNH2/iso:B" EXACT PRO-short-label [PRO:DNx]
synonym: "Kcnh2 isoform 3 (mouse)" EXACT [PRO:DNx]
synonym: "potassium voltage-gated channel subfamily H member 2 isoform 3 (mouse)" EXACT [UniProtKB:O35219]
synonym: "potassium voltage-gated channel subfamily H member 2 isoform 1B (mouse)" EXACT [UniProtKB:O35219]
xref: UniProtKB:O35219-3
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000958 ! voltage-gated potassium channel KCNH2 isoform B

[Term]
id: PR:Q12809-7
name: potassium voltage-gated channel subfamily H member 2 isoform h3.1 (human)
def: "A potassium voltage-gated channel subfamily H member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-7." [PRO:DNx, UniProtKB:Q12809]
comment: Category=organism-sequence.
synonym: "hKCNH2/iso:h3.1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q12809-7
is_a: PR:Q12809 ! potassium voltage-gated channel subfamily H member 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q12809-6
name: potassium voltage-gated channel subfamily H member 2 isoform B-USO (human)
def: "A potassium voltage-gated channel subfamily H member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-6." [PRO:DNx, UniProtKB:Q12809]
comment: Category=organism-sequence.
synonym: "hKCNH2/iso:B-USO" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q12809-6
is_a: PR:Q12809 ! potassium voltage-gated channel subfamily H member 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O35219-2
name: potassium voltage-gated channel subfamily H member 2 isoform 1A' (mouse)
def: "A voltage-gated potassium channel KCNH2 isoform 1A' that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:O35219]
comment: Category=organism-sequence.
synonym: "mKCNH2/iso:1A'" EXACT PRO-short-label [PRO:DNx]
synonym: "Kcnh2 isoform 2 (mouse)" EXACT [PRO:DNx]
synonym: "potassium voltage-gated channel subfamily H member 2 isoform 2 (mouse)" EXACT [UniProtKB:O35219]
xref: UniProtKB:O35219-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000960 ! voltage-gated potassium channel KCNH2 isoform 1A'

[Term]
id: PR:000045393
name: voltage-gated potassium channel KCNH2 isoform A unphosphorylated form (human)
def: "A potassium voltage-gated channel subfamily H member 2 isoform A (human) that lacks phosphorylated residues." [PMID:10837251, PRO:CNA]
comment: Category=organism-modification.
synonym: "hKCNH2/iso:A/PhosRes-" EXACT PRO-short-label [PRO:DAN]
intersection_of: lacks_part MOD:00696 ! phosphorylated residue
intersection_of: PR:Q12809-1 ! potassium voltage-gated channel subfamily H member 2 isoform A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045392
name: voltage-gated potassium channel KCNH2 isoform A non-glycosylated 1 (human)
def: "A voltage-gated potassium channel KCNH2 isoform A non-glycosylated 1 in human. UniProtKB:Q12809-1, Asn-598, PR:000026291." [PMID:12063277, PRO:CNA]
comment: Category=organism-modification.
synonym: "hKCNH2/iso:A/UnGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q12809-1, Asn-598, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000045391 ! voltage-gated potassium channel KCNH2 isoform A non-glycosylated 1

[Term]
id: PR:000045391
name: voltage-gated potassium channel KCNH2 isoform A non-glycosylated 1
def: "A voltage-gated potassium channel KCNH2 isoform A that lacks a glycosylated Asn residue in the Nx[T/S] motif located approximately 26 amino acids downstream of the S5 transmembrane domain. Example: UniProtKB:Q12809-1, Asn-598, PR:000026291." [PMID:12063277]
comment: Category=modification.
synonym: "KCNH2/iso:A/UnGlyco:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000957 ! voltage-gated potassium channel KCNH2 isoform A

[Term]
id: PR:000002666
name: voltage-gated potassium channel KCNH2 isoform A unmodified form
def: "A voltage-gated potassium channel KCNH2 isoform A that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "KCNH2/iso:1/UnMod" EXACT [PRO:DNx]
synonym: "KCNH2/iso:A/UnMod" EXACT PRO-short-label [PRO:DNx]
synonym: "voltage-gated potassium channel KCNH2 isoform 1 unmodified form" EXACT [PRO:DNx]
intersection_of: PR:000000957 ! voltage-gated potassium channel KCNH2 isoform A
intersection_of: has_part PR:000021935 ! immature protein part
intersection_of: lacks_part PR:000025513 ! modified amino-acid residue
disjoint_from: PR:000018264 ! proteolytic cleavage product

[Term]
id: PR:000000960
name: voltage-gated potassium channel KCNH2 isoform 1A'
def: "A voltage-gated potassium channel KCNH2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O35219-2 or a 1:1 ortholog thereof." [PMID:9351462, PRO:CNA, PRO:DAN]
comment: Category=sequence. Note: This form has rapid deactivation kinetics.
synonym: "erg1a'" EXACT []
synonym: "KCNH2/iso:1A'" EXACT PRO-short-label [PRO:DNx]
synonym: "voltage-gated potassium channel KCNH2 isoform 4" EXACT [PRO:DNx]
is_a: PR:000000791 ! voltage-gated potassium channel KCNH2

[Term]
id: PR:Q12809
name: potassium voltage-gated channel subfamily H member 2 (human)
def: "A voltage-gated potassium channel KCNH2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q12809]
comment: Category=organism-gene.
synonym: "ERG" RELATED Gene-based [UniProtKB:Q12809]
synonym: "ERG1" RELATED Gene-based [UniProtKB:Q12809]
synonym: "HERG" RELATED Gene-based [UniProtKB:Q12809]
synonym: "H-ERG" EXACT [UniProtKB:Q12809]
synonym: "KCNH2" RELATED Gene-based [UniProtKB:Q12809]
synonym: "hERG1" EXACT [UniProtKB:Q12809]
synonym: "hERG-1" EXACT [UniProtKB:Q12809]
synonym: "hKCNH2" EXACT PRO-short-label [PRO:DNx]
synonym: "ERG-1 (human)" EXACT [UniProtKB:Q12809]
synonym: "Eag homolog (human)" EXACT [UniProtKB:Q12809]
synonym: "Eag-related protein 1 (human)" EXACT [UniProtKB:Q12809]
synonym: "ether-a-go-go-related protein 1 (human)" EXACT [UniProtKB:Q12809]
synonym: "ether-a-go-go-related gene potassium channel 1 (human)" EXACT [UniProtKB:Q12809]
synonym: "voltage-gated potassium channel subunit Kv11.1 (human)" EXACT [UniProtKB:Q12809]
xref: UniProtKB:Q12809
xref: Reactome:R-HSA-977529 "PR:Q12809 located_in GO:0005886"
xref: DTO:01100206
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000791 ! voltage-gated potassium channel KCNH2
relationship: has_gene_template HGNC:6251 ! KCNH2 (human)

[Term]
id: PR:000000990
name: voltage-gated potassium channel KCNH2 isoform A phosphorylated form
def: "A voltage-gated potassium channel KCNH2 isoform A that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "KCNH2/iso:1/PhosRes+" EXACT [PRO:DNx]
synonym: "KCNH2/iso:A/PhosRes+" EXACT PRO-short-label [PRO:DNx]
synonym: "voltage-gated potassium channel KCNH2 isoform 1 phosphorylated form" EXACT [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000957 ! voltage-gated potassium channel KCNH2 isoform A

[Term]
id: PR:000000998
name: voltage-gated potassium channel KCNH2 isoform A N-glycosylated 1
def: "A voltage-gated potassium channel KCNH2 isoform A glycosylated form that has been glycosylated at the Asn residue within the Nx[T/S] motif located approximately 26 amino acids downstream of the S5 transmembrane domain. Example: UniProtKB:Q12809-1, Asn-598, MOD:00160." [PMID:12063277]
comment: Category=modification.
synonym: "KCNH2/iso:1/Glyco:1" EXACT [PRO:DNx]
synonym: "KCNH2/iso:A/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "voltage-gated potassium channel KCNH2 isoform 1 glycosylated 1" EXACT [PRO:DNx]
is_a: PR:000000989 ! voltage-gated potassium channel KCNH2 isoform A glycosylated form
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: PR:000000999
name: voltage-gated potassium channel KCNH2 isoform A phosphorylated 1
def: "A voltage-gated potassium channel KCNH2 isoform A phosphorylated form in which the phosphorylation occurs at Ser and Thr residues located in the intracellular loops by PKA." [PMID:10837251]
comment: Category=modification.
synonym: "KCNH2/iso:1/Phos:1" EXACT [PRO:DNx]
synonym: "KCNH2/iso:A/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "voltage-gated potassium channel KCNH2 isoform 1 phosphorylated 1" EXACT [PRO:DNx]
is_a: PR:000000990 ! voltage-gated potassium channel KCNH2 isoform A phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:O35219-1
name: potassium voltage-gated channel subfamily H member 2 isoform A (mouse)
def: "A voltage-gated potassium channel KCNH2 isoform A that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mKCNH2/iso:A" EXACT PRO-short-label [PRO:DNx]
synonym: "potassium voltage-gated channel subfamily H member 2 isoform 1 (mouse)" EXACT [UniProtKB:O35219]
synonym: "potassium voltage-gated channel subfamily H member 2 isoform 1A (mouse)" EXACT [UniProtKB:O35219]
xref: UniProtKB:O35219-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000957 ! voltage-gated potassium channel KCNH2 isoform A

[Term]
id: PR:000036581
name: voltage-gated potassium channel KCNH2 isoform A N-glycosylated 1 (human)
def: "A voltage-gated potassium channel KCNH2 isoform A N-glycosylated 1 in human. UniProtKB:Q12809-1, Asn-598, MOD:00160." [PMID:12063277, PRO:CNA]
comment: Category=organism-modification.
synonym: "hKCNH2/iso:1/Glyco:1" EXACT [PRO:DNx]
synonym: "hKCNH2/iso:A/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q12809-1, Asn-598, MOD:00160" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "voltage-gated potassium channel KCNH2 isoform 1 glycosylated 1 (human)" EXACT [PRO:CNA]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000998 ! voltage-gated potassium channel KCNH2 isoform A N-glycosylated 1
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: PR:000036582
name: voltage-gated potassium channel KCNH2 isoform A N-glycosylated 1 (mouse)
def: "A voltage-gated potassium channel KCNH2 isoform A N-glycosylated 1 in mouse. UniProtKB:O35219-1, Asn-600, MOD:00160." [PMID:14668215, PRO:CNA]
comment: Category=organism-modification. Note: Positional information inferred by alignment with human protein represented by PR:000036581 [PRO:DAN].
synonym: "mKCNH2/iso:1/Glyco:1" EXACT [PRO:DNx]
synonym: "mKCNH2/iso:A/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O35219-1, Asn-600, MOD:00160" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "voltage-gated potassium channel KCNH2 isoform 1 glycosylated 1 (mouse)" EXACT [PRO:CNA]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000998 ! voltage-gated potassium channel KCNH2 isoform A N-glycosylated 1
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: PR:000036583
name: voltage-gated potassium channel KCNH2 isoform A phosphorylated 1 (human)
def: "A voltage-gated potassium channel KCNH2 isoform A phosphorylated 1 in human." [PMID:10837251, PRO:CNA]
comment: Category=organism-modification.
synonym: "hKCNH2/iso:1/Phos:1" EXACT [PRO:DNx]
synonym: "hKCNH2/iso:A/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "voltage-gated potassium channel KCNH2 isoform 1 phosphorylated 1 (human)" EXACT [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000999 ! voltage-gated potassium channel KCNH2 isoform A phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:Q12809-4
name: potassium voltage-gated channel subfamily H member 2 isoform h4 (human)
def: "A potassium voltage-gated channel subfamily H member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-4." [PRO:DNx, UniProtKB:Q12809]
comment: Category=organism-sequence.
synonym: "hKCNH2/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q12809-4
is_a: PR:Q12809 ! potassium voltage-gated channel subfamily H member 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000958
name: voltage-gated potassium channel KCNH2 isoform B
def: "A voltage-gated potassium channel KCNH2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-2 or a 1:1 ortholog thereof." [PMID:9351446, PMID:9351462, PRO:CNA, PRO:DAN]
comment: Category=sequence. Note: This form has rapid deactivation kinetics.
synonym: "ERG1b" EXACT []
synonym: "KCNH2/iso:B" EXACT PRO-short-label [PRO:DNx]
synonym: "voltage-gated potassium channel KCNH2 isoform 2" EXACT [PRO:DNx]
is_a: PR:000000791 ! voltage-gated potassium channel KCNH2

[Term]
id: PR:000000959
name: voltage-gated potassium channel KCNH2 isoform A-USO
def: "A voltage-gated potassium channel KCNH2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-5 or a 1:1 ortholog thereof." [PMID:9765245, PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "ERG A-USO" RELATED []
synonym: "KCNH2/iso:A-USO" EXACT PRO-short-label [PRO:DNx]
synonym: "voltage-gated potassium channel KCNH2 isoform 3" RELATED [PRO:DNx]
is_a: PR:000000791 ! voltage-gated potassium channel KCNH2

[Term]
id: PR:000000957
name: voltage-gated potassium channel KCNH2 isoform A
def: "A voltage-gated potassium channel KCNH2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "KCNH2/iso:A" EXACT PRO-short-label [PRO:DNx]
synonym: "voltage-gated potassium channel KCNH2 isoform 1" EXACT [PRO:CNA, PRO:DAN]
is_a: PR:000000791 ! voltage-gated potassium channel KCNH2