[Term]
id: PR:000000725
name: voltage-gated potassium channel KCNV1
def: "A voltage-gated potassium channel alpha subunit that is a translation product of the human KCNV1 gene or a 1:1 ortholog thereof. It has an atypical S6 segment containing the structural elements that modify inactivation of Kv2 channels. Similarly to KCNF1, KCNV1 and KCNS, KCNV2 subunits are not able to form functional channels on their own. Also in common with these modulatory subunits, it lacks the conserved PxP motif located in the distal part of S6. In this class the motif is PIA. The alteration of the PxP motif seems to be an important determinant of the regulatory function of modulatory subunits. It modulates the activity of KCNB1 and KCNB2 channels by changing kinetics and levels of expression and by shifting the half-inactivation potential to more polarized values." [PMID:16382104]
comment: Category=gene.
synonym: "KCNV1" EXACT PRO-short-label [PRO:DNx]
synonym: "neuronal potassium channel alpha subunit HNKA" EXACT []
synonym: "voltage-gated potassium channel subunit Kv8.1" EXACT []
xref: IUPHARobj:565
xref: PANTHER:PTHR11537:SF38
is_a: PR:000000685 ! voltage-gated potassium channel alpha subunit

[Term]
id: PR:Q9XXD1
name: probable voltage-gated potassium channel subunit kvs-4 (worm)
def: "A voltage-gated potassium channel KCNV1 that is encoded in the genome of worm." [PRO:DNx, UniProtKB:Q9XXD1]
comment: Category=organism-gene.
synonym: "kvs-4" RELATED Gene-based [UniProtKB:Q9XXD1]
synonym: "Y48A6B.6" RELATED Gene-based [UniProtKB:Q9XXD1]
synonym: "KCNV1 (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9XXD1
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000000725 ! voltage-gated potassium channel KCNV1
relationship: has_gene_template WormBase:WBGene00012967 ! kvs-4 (worm)

[Term]
id: PR:Q9XXD1-2
name: probable voltage-gated potassium channel subunit kvs-4 isoform b (worm)
def: "A probable voltage-gated potassium channel subunit kvs-4 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9XXD1-2." [PRO:DNx, UniProtKB:Q9XXD1]
comment: Category=organism-sequence.
synonym: "KCNV1/iso:b (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9XXD1-2
is_a: PR:Q9XXD1 ! probable voltage-gated potassium channel subunit kvs-4 (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:Q9XXD1-1
name: probable voltage-gated potassium channel subunit kvs-4 isoform a (worm)
def: "A probable voltage-gated potassium channel subunit kvs-4 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9XXD1-1." [PRO:DNx, UniProtKB:Q9XXD1]
comment: Category=organism-sequence.
synonym: "KCNV1/iso:a (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9XXD1-1
is_a: PR:Q9XXD1 ! probable voltage-gated potassium channel subunit kvs-4 (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans