[Term]
id: PR:O88703-1
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 (mouse)
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mHCN2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O88703-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000756 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1

[Term]
id: PR:000000985
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 glycosylated form with N-glycosylation at the N-linked glycosylation consensus sequence (Nx[ST]) in the extracellular domain between S5 and S6 transmembrane segments. Example: UniProtKB:O88703-1, Asn-380, MOD:00160." [PMID:12928435]
comment: Category=modification.
synonym: "HCN2/iso:1/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000936 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 glycosylated form
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: PR:000000936
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 glycosylated form
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 that includes at least one glycosylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "HCN2/iso:1/GlycoRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00693 ! glycosylated residue
intersection_of: PR:000000756 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1

[Term]
id: PR:000036574
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 (mouse)
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 in mouse. UniProtKB:O88703-1, Asn-380, MOD:00160." [PMID:12928435, PRO:CNA]
comment: Category=organism-modification.
synonym: "mHCN2/iso:1/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O88703-1, Asn-380, MOD:00160" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000985 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: PR:000046119
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 phosphorylated 1 (mouse)
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (mouse) that has been phosphorylated at Ser-641. UniProtKB:O88703, Ser-641, MOD:00046." [PMID:21347269, iPTMnet:O88703]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:21347269). Status=unreviewed.
synonym: "mHCN2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O88703, Ser-641, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:O88703 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (mouse)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000000756
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88703-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "HCN2/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000706 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

[Term]
id: PR:000000706
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein that is a translation product of the human HCN2 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "HCN2" EXACT PRO-short-label [PRO:DNx]
synonym: "Hac1" RELATED Gene-based []
synonym: "BCNG2" RELATED Gene-based []
synonym: "HAC-1" EXACT []
synonym: "BCNG-2" EXACT []
synonym: "brain cyclic nucleotide-gated channel 2" EXACT []
synonym: "hyperpolarization-activated cation channel 1" EXACT []
xref: IUPHARobj:401
xref: PIRSF:PIRSF500961
is_a: PR:000000676 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein

[Term]
id: PR:Q9UL51
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (human)
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9UL51]
comment: Category=organism-gene.
synonym: "HCN2" RELATED Gene-based [UniProtKB:Q9UL51]
synonym: "BCNG2" RELATED Gene-based [UniProtKB:Q9UL51]
synonym: "hHCN2" EXACT PRO-short-label [PRO:DNx]
synonym: "BCNG-2 (human)" EXACT [UniProtKB:Q9UL51]
synonym: "brain cyclic nucleotide-gated channel 2 (human)" EXACT [UniProtKB:Q9UL51]
xref: UniProtKB:Q9UL51
xref: Reactome:R-HSA-977502 "PR:Q9UL51 located_in GO:0005886"
xref: DTO:01100145
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000706 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
relationship: has_gene_template HGNC:4846 ! HCN2 (human)

[Term]
id: PR:Q9JKA9
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (rat)
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is encoded in the genome of rat." [OMA:Q9JKA9, PANTHER:PTHR10217:SF372, PRO:DNx]
comment: Category=organism-gene.
synonym: "Hcn2" RELATED Gene-based [UniProtKB:Q9JKA9]
synonym: "rHCN2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9JKA9
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000706 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
relationship: has_gene_template RGD:620689 ! Hcn2 (rat)

[Term]
id: PR:O88703
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (mouse)
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is encoded in the genome of mouse." [OMA:O88703, PRO:DNx]
comment: Category=organism-gene.
synonym: "Hac1" RELATED Gene-based [UniProtKB:O88703]
synonym: "Hcn2" RELATED Gene-based [UniProtKB:O88703]
synonym: "Bcng2" RELATED Gene-based [UniProtKB:O88703]
synonym: "mHCN2" EXACT PRO-short-label [PRO:DNx]
synonym: "HAC-1 (mouse)" EXACT [UniProtKB:O88703]
synonym: "BCNG-2 (mouse)" EXACT [UniProtKB:O88703]
synonym: "brain cyclic nucleotide-gated channel 2 (mouse)" EXACT [UniProtKB:O88703]
synonym: "hyperpolarization-activated cation channel 1 (mouse)" EXACT [UniProtKB:O88703]
xref: UniProtKB:O88703
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000706 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
relationship: has_gene_template MGI:1298210 ! Hcn2 (mouse)