[Term]
id: PR:000000686
name: cGMP-gated cation channel alpha-1
def: "A cyclic nucleotide-gated channel alpha subunit that is a translation product of the human CNGA1 gene or a 1:1 ortholog thereof. In the retina, these proteins can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors." [PRO:CNA]
comment: Category=gene.
synonym: "CNCG" RELATED Gene-based []
synonym: "CNG1" EXACT []
synonym: "CNCG1" RELATED Gene-based []
synonym: "CNG-1" EXACT []
synonym: "CNGA1" EXACT PRO-short-label [PRO:DNx]
synonym: "CNG channel alpha-1" EXACT []
synonym: "cyclic nucleotide-gated channel alpha-1" EXACT []
synonym: "cyclic nucleotide-gated cation channel 1" EXACT []
synonym: "cyclic nucleotide-gated channel, photoreceptor" EXACT []
synonym: "rod photoreceptor cGMP-gated channel subunit alpha" EXACT []
xref: IUPHARobj:394
is_a: PR:000000673 ! cyclic nucleotide-gated channel alpha subunit

[Term]
id: PR:000045381
name: cGMP-gated cation channel alpha-1 isoform 1 unphosphorylated 1 (cow)
def: "A cGMP-gated cation channel alpha-1 isoform 1 (cow) that lacks phosphorylation on Tyr-498. UniProtKB:Q00194-1, Tyr-498, PR:000026291." [PMID:10366613, PRO:CNA]
comment: Category=organism-modification.
synonym: "cow-CNGA1/iso:1/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q00194-1, Tyr-498, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q00194-1 ! cGMP-gated cation channel alpha-1 isoform 1 (cow)
relationship: only_in_taxon NCBITaxon:9913 ! Bos taurus

[Term]
id: PR:Q00194
name: cGMP-gated cation channel alpha-1 (cow)
def: "A cGMP-gated cation channel alpha-1 that is encoded in the genome of cow." [OMA:Q00194, PRO:DNx]
comment: Category=organism-gene.
synonym: "CNCG" RELATED Gene-based [UniProtKB:Q00194]
synonym: "CNCG1" RELATED Gene-based [UniProtKB:Q00194]
synonym: "CNGA1" RELATED Gene-based [UniProtKB:Q00194]
synonym: "cow-CNGA1" EXACT PRO-short-label [PRO:DNx]
synonym: "CNG1 (cow)" EXACT [UniProtKB:Q00194]
synonym: "CNG-1 (cow)" EXACT [UniProtKB:Q00194]
synonym: "CNG channel alpha-1 (cow)" EXACT [UniProtKB:Q00194]
synonym: "cyclic nucleotide-gated channel alpha-1 (cow)" EXACT [UniProtKB:Q00194]
synonym: "cyclic nucleotide-gated cation channel 1 (cow)" EXACT [UniProtKB:Q00194]
synonym: "cyclic nucleotide-gated channel, photoreceptor (cow)" EXACT [UniProtKB:Q00194]
synonym: "rod photoreceptor cGMP-gated channel subunit alpha (cow)" EXACT [UniProtKB:Q00194]
xref: UniProtKB:Q00194
intersection_of: only_in_taxon NCBITaxon:9913 ! Bos taurus
intersection_of: PR:000000686 ! cGMP-gated cation channel alpha-1
relationship: has_gene_template NCBIGene:281700 ! CNGA1 (cow)

[Term]
id: PR:000036569
name: cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1 (cow)
def: "A cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1 in cow. UniProtKB:Q00194-1, Tyr-498, MOD:00048." [PMID:10366613, PMID:14602825, PRO:CNA]
comment: Category=organism-modification.
synonym: "cow-CNGA1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q00194-1, Tyr-498, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9913 ! Bos taurus
intersection_of: PR:000000981 ! cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000045379
name: cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 2 (cow)
def: "A cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 2 in cow. UniProtKB:Q00194-1, Tyr-498/Tyr-503, MOD:00048." [PMID:15381690, PRO:CNA]
comment: Category=organism-modification. Kinase=("INSR"; PR:000009064; Tyr-498/Tyr-503). Evidence=(ECO:0000006, based on PMID:15381690).
synonym: "cow-CNGA1/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q00194-1, Tyr-498/Tyr-503, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9913 ! Bos taurus
intersection_of: PR:000045378 ! cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 2
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:Q00194-1
name: cGMP-gated cation channel alpha-1 isoform 1 (cow)
def: "A cGMP-gated cation channel alpha-1 isoform 1 that is encoded in the genome of cow." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "cow-CNGA1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q00194-1
intersection_of: only_in_taxon NCBITaxon:9913 ! Bos taurus
intersection_of: PR:000000737 ! cGMP-gated cation channel alpha-1 isoform 1