[Term]
id: PR:000000686
name: cGMP-gated cation channel alpha-1
def: "A cyclic nucleotide-gated channel alpha subunit that is a translation product of the human CNGA1 gene or a 1:1 ortholog thereof. In the retina, these proteins can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors." [PRO:CNA]
comment: Category=gene.
synonym: "CNCG" RELATED Gene-based []
synonym: "CNG1" EXACT []
synonym: "CNCG1" RELATED Gene-based []
synonym: "CNG-1" EXACT []
synonym: "CNGA1" EXACT PRO-short-label [PRO:DNx]
synonym: "CNG channel alpha-1" EXACT []
synonym: "cyclic nucleotide-gated channel alpha-1" EXACT []
synonym: "cyclic nucleotide-gated cation channel 1" EXACT []
synonym: "cyclic nucleotide-gated channel, photoreceptor" EXACT []
synonym: "rod photoreceptor cGMP-gated channel subunit alpha" EXACT []
xref: IUPHARobj:394
is_a: PR:000000673 ! cyclic nucleotide-gated channel alpha subunit

[Term]
id: PR:000000981
name: cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1
def: "A cGMP-gated cation channel alpha-1 isoform 1 phosphorylated form in which the phosphorylation occurs at the Tyr residue within the VYSPGD motif located at the N terminus of the cyclic-nucleotide binding domain (CNDB). Example: UniProtKB:Q00194-1, Tyr-498, MOD:00048." [PMID:10366613, PMID:14602825]
comment: Category=modification. Note: This phosphorylation prevents Ca2+/CaM inhibition of the CNG channel, but at the same time decreases the apparent affinity for cGMP.
synonym: "CNGA1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000932 ! cGMP-gated cation channel alpha-1 isoform 1 phosphorylated form
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000000932
name: cGMP-gated cation channel alpha-1 isoform 1 phosphorylated form
def: "A cGMP-gated cation channel alpha-1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "CNGA1/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000737 ! cGMP-gated cation channel alpha-1 isoform 1

[Term]
id: PR:Q90980
name: cyclic nucleotide-gated channel rod photoreceptor subunit alpha (chicken)
def: "A cGMP-gated cation channel alpha-1 that is encoded in the genome of chicken." [OMA:Q90980, PANTHER:PTHR10217:SF387, PRO:DNx]
comment: Category=organism-gene.
synonym: "CNGA1" RELATED Gene-based [UniProtKB:Q90980]
synonym: "chick-CNGA1" EXACT PRO-short-label [PRO:DNx]
synonym: "CNG3 (chicken)" EXACT [UniProtKB:Q90980]
synonym: "CNG-3 (chicken)" EXACT [UniProtKB:Q90980]
synonym: "CNG channel 3 (chicken)" EXACT [UniProtKB:Q90980]
xref: UniProtKB:Q90980
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000000686 ! cGMP-gated cation channel alpha-1
relationship: has_gene_template CGNC:10542 ! CNGA1 (chicken)

[Term]
id: PR:P29973-1
name: cGMP-gated cation channel alpha-1 isoform 1 (human)
def: "A cGMP-gated cation channel alpha-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hCNGA1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P29973-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000737 ! cGMP-gated cation channel alpha-1 isoform 1

[Term]
id: PR:P29974
name: cGMP-gated cation channel alpha-1 (mouse)
def: "A cGMP-gated cation channel alpha-1 that is encoded in the genome of mouse." [OMA:P29974, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cncg" RELATED Gene-based [UniProtKB:P29974]
synonym: "Cncg1" RELATED Gene-based [UniProtKB:P29974]
synonym: "Cnga1" RELATED Gene-based [UniProtKB:P29974]
synonym: "mCNGA1" EXACT PRO-short-label [PRO:DNx]
synonym: "CNG1 (mouse)" EXACT [UniProtKB:P29974]
synonym: "CNG-1 (mouse)" EXACT [UniProtKB:P29974]
synonym: "CNG channel alpha-1 (mouse)" EXACT [UniProtKB:P29974]
synonym: "cyclic nucleotide-gated channel alpha-1 (mouse)" EXACT [UniProtKB:P29974]
synonym: "cyclic nucleotide-gated cation channel 1 (mouse)" EXACT [UniProtKB:P29974]
synonym: "cyclic nucleotide-gated channel, photoreceptor (mouse)" EXACT [UniProtKB:P29974]
synonym: "rod photoreceptor cGMP-gated channel subunit alpha (mouse)" EXACT [UniProtKB:P29974]
xref: UniProtKB:P29974
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000686 ! cGMP-gated cation channel alpha-1
relationship: has_gene_template MGI:88436 ! Cnga1 (mouse)

[Term]
id: PR:000045381
name: cGMP-gated cation channel alpha-1 isoform 1 unphosphorylated 1 (cow)
def: "A cGMP-gated cation channel alpha-1 isoform 1 (cow) that lacks phosphorylation on Tyr-498. UniProtKB:Q00194-1, Tyr-498, PR:000026291." [PMID:10366613, PRO:CNA]
comment: Category=organism-modification.
synonym: "cow-CNGA1/iso:1/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q00194-1, Tyr-498, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q00194-1 ! cGMP-gated cation channel alpha-1 isoform 1 (cow)
relationship: only_in_taxon NCBITaxon:9913 ! Bos taurus

[Term]
id: PR:000045379
name: cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 2 (cow)
def: "A cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 2 in cow. UniProtKB:Q00194-1, Tyr-498/Tyr-503, MOD:00048." [PMID:15381690, PRO:CNA]
comment: Category=organism-modification. Kinase=("INSR"; PR:000009064; Tyr-498/Tyr-503). Evidence=(ECO:0000006, based on PMID:15381690).
synonym: "cow-CNGA1/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q00194-1, Tyr-498/Tyr-503, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9913 ! Bos taurus
intersection_of: PR:000045378 ! cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 2
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000045378
name: cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 2
def: "A cGMP-gated cation channel alpha-1 isoform 1 phosphorylated form in which the phosphorylation occurs at the Tyr residue within the VYSPGD motif located at the N terminus of the cyclic-nucleotide binding domain (CNDB) and the residue at the position equivalent to Tyr-503 of the amino acid sequence represented by UniProtKB:Q00194-1. This phosphorylation prevents Ca2+/CaM inhibition of the CNG channel, but at the same time has a similar effect, that is decreases the apparent affinity for cGMP. Example: UniProtKB:Q00194-1, Tyr-498/Tyr-503, MOD:00048." [PMID:23032687, PRO:CNA, PRO:DAN]
comment: Category=modification.
synonym: "CNGA1/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000932 ! cGMP-gated cation channel alpha-1 isoform 1 phosphorylated form
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:Q62927
name: cGMP-gated cation channel alpha-1 (rat)
def: "A cGMP-gated cation channel alpha-1 that is encoded in the genome of rat." [OMA:Q62927, PANTHER:PTHR10217:SF387, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cncg" RELATED Gene-based [UniProtKB:Q62927]
synonym: "Cncg1" RELATED Gene-based [UniProtKB:Q62927]
synonym: "Cnga1" RELATED Gene-based [UniProtKB:Q62927]
synonym: "rCNGA1" EXACT PRO-short-label [PRO:DNx]
synonym: "CNG1 (rat)" EXACT [UniProtKB:Q62927]
synonym: "CNG-1 (rat)" EXACT [UniProtKB:Q62927]
synonym: "CNG channel alpha-1 (rat)" EXACT [UniProtKB:Q62927]
synonym: "cyclic nucleotide-gated channel alpha-1 (rat)" EXACT [UniProtKB:Q62927]
synonym: "cyclic nucleotide-gated cation channel 1 (rat)" EXACT [UniProtKB:Q62927]
synonym: "cyclic nucleotide-gated channel, photoreceptor (rat)" EXACT [UniProtKB:Q62927]
synonym: "rod photoreceptor cGMP-gated channel subunit alpha (rat)" EXACT [UniProtKB:Q62927]
xref: UniProtKB:Q62927
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000686 ! cGMP-gated cation channel alpha-1
relationship: has_gene_template RGD:621815 ! Cnga1 (rat)

[Term]
id: PR:P29973
name: cGMP-gated cation channel alpha-1 (human)
def: "A cGMP-gated cation channel alpha-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P29973]
comment: Category=organism-gene.
synonym: "CNCG" RELATED Gene-based [UniProtKB:P29973]
synonym: "CNCG1" RELATED Gene-based [UniProtKB:P29973]
synonym: "CNGA1" RELATED Gene-based [UniProtKB:P29973]
synonym: "hCNGA1" EXACT PRO-short-label [PRO:DNx]
synonym: "CNG1 (human)" EXACT [UniProtKB:P29973]
synonym: "CNG-1 (human)" EXACT [UniProtKB:P29973]
synonym: "CNG channel alpha-1 (human)" EXACT [UniProtKB:P29973]
synonym: "cyclic nucleotide-gated channel alpha-1 (human)" EXACT [UniProtKB:P29973]
synonym: "cyclic nucleotide-gated cation channel 1 (human)" EXACT [UniProtKB:P29973]
synonym: "cyclic nucleotide-gated channel, photoreceptor (human)" EXACT [UniProtKB:P29973]
synonym: "rod photoreceptor cGMP-gated channel subunit alpha (human)" EXACT [UniProtKB:P29973]
xref: Reactome:R-HSA-52425 "PR:P29973 located_in GO:0005886"
xref: DTO:01100085
xref: UniProtKB:P29973
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000686 ! cGMP-gated cation channel alpha-1
relationship: has_gene_template HGNC:2148 ! CNGA1 (human)

[Term]
id: PR:P29974-1
name: cGMP-gated cation channel alpha-1 isoform 1 (mouse)
def: "A cGMP-gated cation channel alpha-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mCNGA1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P29974-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000737 ! cGMP-gated cation channel alpha-1 isoform 1

[Term]
id: PR:Q00194
name: cGMP-gated cation channel alpha-1 (cow)
def: "A cGMP-gated cation channel alpha-1 that is encoded in the genome of cow." [OMA:Q00194, PRO:DNx]
comment: Category=organism-gene.
synonym: "CNCG" RELATED Gene-based [UniProtKB:Q00194]
synonym: "CNCG1" RELATED Gene-based [UniProtKB:Q00194]
synonym: "CNGA1" RELATED Gene-based [UniProtKB:Q00194]
synonym: "cow-CNGA1" EXACT PRO-short-label [PRO:DNx]
synonym: "CNG1 (cow)" EXACT [UniProtKB:Q00194]
synonym: "CNG-1 (cow)" EXACT [UniProtKB:Q00194]
synonym: "CNG channel alpha-1 (cow)" EXACT [UniProtKB:Q00194]
synonym: "cyclic nucleotide-gated channel alpha-1 (cow)" EXACT [UniProtKB:Q00194]
synonym: "cyclic nucleotide-gated cation channel 1 (cow)" EXACT [UniProtKB:Q00194]
synonym: "cyclic nucleotide-gated channel, photoreceptor (cow)" EXACT [UniProtKB:Q00194]
synonym: "rod photoreceptor cGMP-gated channel subunit alpha (cow)" EXACT [UniProtKB:Q00194]
xref: UniProtKB:Q00194
intersection_of: only_in_taxon NCBITaxon:9913 ! Bos taurus
intersection_of: PR:000000686 ! cGMP-gated cation channel alpha-1
relationship: has_gene_template NCBIGene:281700 ! CNGA1 (cow)

[Term]
id: PR:000036569
name: cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1 (cow)
def: "A cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1 in cow. UniProtKB:Q00194-1, Tyr-498, MOD:00048." [PMID:10366613, PMID:14602825, PRO:CNA]
comment: Category=organism-modification.
synonym: "cow-CNGA1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q00194-1, Tyr-498, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9913 ! Bos taurus
intersection_of: PR:000000981 ! cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000000737
name: cGMP-gated cation channel alpha-1 isoform 1
def: "A cGMP-gated cation channel alpha-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29973-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "CNGA1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000686 ! cGMP-gated cation channel alpha-1

[Term]
id: PR:000000738
name: cGMP-gated cation channel alpha-1 sequence variant S320F (human)
def: "A cGMP-gated cation channel alpha-1 (human) that has a Phe residue at the position equivalent to Ser-320 of the amino acid sequence represented by UniProtKB:P29973-1. Example: UniProtKB:P29973-1, Ser-320, CHEBI:29997." [PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hCNGA1/var:S320F" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P29973-1, Ser-320, CHEBI:29997" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "cGMP-gated cation channel alpha-1 sequence variant 1 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_009297
is_a: PR:P29973 ! cGMP-gated cation channel alpha-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q00194-1
name: cGMP-gated cation channel alpha-1 isoform 1 (cow)
def: "A cGMP-gated cation channel alpha-1 isoform 1 that is encoded in the genome of cow." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "cow-CNGA1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q00194-1
intersection_of: only_in_taxon NCBITaxon:9913 ! Bos taurus
intersection_of: PR:000000737 ! cGMP-gated cation channel alpha-1 isoform 1