[Term]
id: PR:000000672
name: cation channel sperm-associated auxiliary subunit beta
def: "A protein that is a translation product of the human CATSPERB gene or a 1:1 ortholog thereof. Members of this class are auxiliary proteins to the CatSper channel. They have four putative transmembrane-spanning domains. In mammals, four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel." [PMID:17478420, PRO:CNA]
comment: Category=gene.
synonym: "CATSPERB" EXACT PRO-short-label [PRO:DNx]
synonym: "C14orf161" RELATED Gene-based []
synonym: "CatSper-beta" EXACT []
xref: PIRSF:PIRSF038543
is_a: PR:000000001 ! protein