[Term]
id: PR:Q9H7T0-1
name: cation channel sperm-associated auxiliary subunit beta isoform 1 (human)
def: "A cation channel sperm-associated auxiliary subunit beta isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hCATSPERB/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9H7T0-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000695 ! cation channel sperm-associated auxiliary subunit beta isoform 1

[Term]
id: PR:Q9H7T0
name: cation channel sperm-associated auxiliary subunit beta (human)
def: "A cation channel sperm-associated auxiliary subunit beta that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9H7T0]
comment: Category=organism-gene.
synonym: "CATSPERB" RELATED Gene-based [UniProtKB:Q9H7T0]
synonym: "C14orf161" RELATED Gene-based [UniProtKB:Q9H7T0]
synonym: "hCATSPERB" EXACT PRO-short-label [PRO:DNx]
synonym: "CatSper-beta (human)" EXACT [UniProtKB:Q9H7T0]
xref: UniProtKB:Q9H7T0
xref: Reactome:R-HSA-2534369 "PR:Q9H7T0 located_in GO:0005886"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000672 ! cation channel sperm-associated auxiliary subunit beta
relationship: has_gene_template HGNC:20500 ! CATSPERB (human)

[Term]
id: PR:000000672
name: cation channel sperm-associated auxiliary subunit beta
def: "A protein that is a translation product of the human CATSPERB gene or a 1:1 ortholog thereof. Members of this class are auxiliary proteins to the CatSper channel. They have four putative transmembrane-spanning domains. In mammals, four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel." [PMID:17478420, PRO:CNA]
comment: Category=gene.
synonym: "CATSPERB" EXACT PRO-short-label [PRO:DNx]
synonym: "C14orf161" RELATED Gene-based []
synonym: "CatSper-beta" EXACT []
xref: PIRSF:PIRSF038543
is_a: PR:000000001 ! protein

[Term]
id: PR:Q9H7T0-2
name: cation channel sperm-associated auxiliary subunit beta isoform h2 (human)
def: "A cation channel sperm-associated auxiliary subunit beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H7T0-2." [PRO:DNx, UniProtKB:Q9H7T0]
comment: Category=organism-sequence.
synonym: "hCATSPERB/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9H7T0-2
is_a: PR:Q9H7T0 ! cation channel sperm-associated auxiliary subunit beta (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens