[Term]
id: PR:Q86XQ3-1
name: cation channel sperm-associated protein 3 isoform 1 (human)
def: "A cation channel sperm-associated protein 3 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hCATSPER3/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q86XQ3-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000693 ! cation channel sperm-associated protein 3 isoform 1

[Term]
id: PR:Q86XQ3
name: cation channel sperm-associated protein 3 (human)
def: "A cation channel sperm-associated protein 3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q86XQ3]
comment: Category=organism-gene.
synonym: "CATSPER3" RELATED Gene-based [UniProtKB:Q86XQ3]
synonym: "hCATSPER3" EXACT PRO-short-label [PRO:DNx]
synonym: "CatSper3 (human)" EXACT [UniProtKB:Q86XQ3]
synonym: "Ca(v)-like protein (human)" EXACT [UniProtKB:Q86XQ3]
synonym: "one-repeat calcium channel-like protein (human)" EXACT [UniProtKB:Q86XQ3]
xref: UniProtKB:Q86XQ3
xref: Reactome:R-HSA-2534360 "PR:Q86XQ3 located_in GO:0005886"
xref: DTO:01100095
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000671 ! cation channel sperm-associated protein 3
relationship: has_gene_template HGNC:20819 ! CATSPER3 (human)

[Term]
id: PR:000000671
name: cation channel sperm-associated protein 3
def: "A CatSper channel protein that is a translation product of the human CATSPER3 gene or a 1:1 ortholog thereof. In mammals, four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. CatSper channels seem to require auxiliary subunits, such as CatSperB (PR:000000672). In common with other channels, CatSper3 proteins have an architecture consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane." [PRO:CNA]
comment: Category=gene.
synonym: "CATSPER3" EXACT PRO-short-label [PRO:DNx]
synonym: "CatSper3" EXACT []
synonym: "Ca(v)-like protein" EXACT []
synonym: "one-repeat calcium channel-like protein" EXACT []
xref: IUPHARobj:390
is_a: PR:000044645 ! CatSper channel protein