[Term]
id: PR:Q91ZR5-1
name: cation channel sperm-associated protein 1 isoform 1 (mouse)
def: "A cation channel sperm-associated protein 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mCATSPER1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q91ZR5-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000688 ! cation channel sperm-associated protein 1 isoform 1

[Term]
id: PR:000000669
name: cation channel sperm-associated protein 1
def: "A CatSper channel protein that is a translation product of the human CATSPER1 gene or a 1:1 ortholog thereof. In mammals, four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. CatSper channels seem to require auxiliary subunits, such as CatSperB (PR:000000672). In common with other channels, CatSper1 proteins have an architecture consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane. Unique to this class is the His-rich N terminus that seems to be involved the pH sensitivity of the channel calcium currents." [PRO:CNA]
comment: Category=gene.
synonym: "CatSper" BROAD [PRO:DAN]
synonym: "CATSPER1" EXACT PRO-short-label [PRO:DNx]
synonym: "CatSper1" EXACT []
xref: IUPHARobj:388
is_a: PR:000044645 ! CatSper channel protein

[Term]
id: PR:Q91ZR5
name: cation channel sperm-associated protein 1 (mouse)
def: "A cation channel sperm-associated protein 1 that is encoded in the genome of mouse." [OMA:Q91ZR5, PRO:DNx]
comment: Category=organism-gene.
synonym: "Catsper1" RELATED Gene-based [UniProtKB:Q91ZR5]
synonym: "mCATSPER1" EXACT PRO-short-label [PRO:DNx]
synonym: "CatSper1 (mouse)" EXACT [UniProtKB:Q91ZR5]
xref: UniProtKB:Q91ZR5
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000669 ! cation channel sperm-associated protein 1
relationship: has_gene_template MGI:2179947 ! Catsper1 (mouse)