[Term]
id: PR:000049802
name: mothers against decapentaplegic homolog 7 isoform A unmethylated 1 (mouse)
def: "A mothers against decapentaplegic homolog 7 isoform A (mouse) that lacks a monomethylated Lys at position 70. UniProtKB:O35253-1, Lys-70, PR:000026291." [PMID:27292644, PRO:HJD]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27292644).
synonym: "mSMAD7/iso:A/UnMe:1" EXACT PRO-short-label [PRO:DNx]
synonym: "mSMAD7 isoform A unmethylated 1" EXACT []
synonym: "UniProtKB:O35253-1, Lys-70, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:O35253-1 ! mothers against decapentaplegic homolog 7 isoform A (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049801
name: mothers against decapentaplegic homolog 7 isoform A monomethylated 1 (mouse)
def: "A mothers against decapentaplegic homolog 7 isoform A (mouse) that has been monomethylated at the position equivalent to Lys-70. UniProtKB:O35253-1, Lys-70, MOD:00085." [PMID:27292644, PRO:HJD]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27292644). Methylase=("Setd7"; PR:Q8VHL1, Lys-70).
synonym: "mSMAD7/iso:A/Me1:1" EXACT PRO-short-label [PRO:DNx]
synonym: "mSMAD7 isoform A K70 methylated" EXACT []
synonym: "UniProtKB:O35253-1, Lys-70, MOD:00085" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:O35253-1 ! mothers against decapentaplegic homolog 7 isoform A (mouse)
relationship: has_part MOD:00085 ! N6-methyl-L-lysine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000000583
name: smad7 isoform 1 phosphorylated form
def: "A smad7 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "SMAD7/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000481 ! smad7 isoform 1

[Term]
id: PR:O35253
name: mothers against decapentaplegic homolog 7 (mouse)
def: "A smad7 that is encoded in the genome of mouse." [OMA:O35253, PRO:DNx]
comment: Category=organism-gene.
synonym: "Madh7" RELATED Gene-based [UniProtKB:O35253]
synonym: "Madh8" RELATED Gene-based [UniProtKB:O35253]
synonym: "Smad7" RELATED Gene-based [UniProtKB:O35253]
synonym: "mSMAD7" EXACT PRO-short-label [PRO:DNx]
synonym: "SMAD 7 (mouse)" EXACT [UniProtKB:O35253]
synonym: "MAD homolog 7 (mouse)" EXACT [UniProtKB:O35253]
synonym: "MAD homolog 8 (mouse)" EXACT [UniProtKB:O35253]
synonym: "SMAD family member 7 (mouse)" EXACT [UniProtKB:O35253]
synonym: "mothers against DPP homolog 7 (mouse)" EXACT [UniProtKB:O35253]
synonym: "mothers against DPP homolog 8 (mouse)" EXACT [UniProtKB:O35253]
synonym: "mothers against decapentaplegic homolog 8 (mouse)" EXACT [UniProtKB:O35253]
xref: UniProtKB:O35253
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000374 ! smad7
relationship: has_gene_template MGI:1100518 ! Smad7 (mouse)

[Term]
id: PR:000000584
name: smad7 isoform 1 ubiquitinated form
def: "A smad7 isoform 1 that includes at least one ubiquitinated lysine." [PRO:CNA]
comment: Category=modification.
synonym: "SMAD7/iso:1/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:000000481 ! smad7 isoform 1

[Term]
id: PR:O88406
name: mothers against decapentaplegic homolog 7 (rat)
def: "A smad7 that is encoded in the genome of rat." [OMA:O88406, PRO:DNx]
comment: Category=organism-gene.
synonym: "Madh7" RELATED Gene-based [UniProtKB:O88406]
synonym: "Smad7" RELATED Gene-based [UniProtKB:O88406]
synonym: "rSMAD7" EXACT PRO-short-label [PRO:DNx]
synonym: "SMAD 7 (rat)" EXACT [UniProtKB:O88406]
synonym: "MAD homolog 7 (rat)" EXACT [UniProtKB:O88406]
synonym: "SMAD family member 7 (rat)" EXACT [UniProtKB:O88406]
synonym: "mothers against DPP homolog 7 (rat)" EXACT [UniProtKB:O88406]
xref: UniProtKB:O88406
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000374 ! smad7
relationship: has_gene_template RGD:69314 ! Smad7 (rat)

[Term]
id: PR:O15105-3
name: mothers against decapentaplegic homolog 7 isoform 3 (human)
def: "A smad7 isoform 3 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hSMAD7/iso:3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O15105-3
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038037 ! smad7 isoform 3

[Term]
id: PR:O15105-2
name: mothers against decapentaplegic homolog 7 isoform h2 (human)
def: "A mothers against decapentaplegic homolog 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15105-2." [PRO:DNx, UniProtKB:O15105]
comment: Category=organism-sequence.
synonym: "hSMAD7/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O15105-2
is_a: PR:O15105 ! mothers against decapentaplegic homolog 7 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O15105-1
name: mothers against decapentaplegic homolog 7 isoform 1 (human)
def: "A smad7 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSMAD7/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O15105-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000481 ! smad7 isoform 1

[Term]
id: PR:000000582
name: smad7 isoform 1 acetylated form
def: "A smad7 isoform 1 that includes at least one acetylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "SMAD7/iso:1/AcRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00394 ! acetylated residue
intersection_of: PR:000000481 ! smad7 isoform 1

[Term]
id: PR:O15105
name: mothers against decapentaplegic homolog 7 (human)
def: "A smad7 that is encoded in the genome of human." []
comment: Category=organism-gene.
synonym: "MADH7" RELATED Gene-based [UniProtKB:O15105]
synonym: "MADH8" RELATED Gene-based [UniProtKB:O15105]
synonym: "SMAD7" RELATED Gene-based [UniProtKB:O15105]
synonym: "hSMAD7" EXACT PRO-short-label [PRO:DNx]
synonym: "Smad7 (human)" EXACT [UniProtKB:O15105]
synonym: "SMAD 7 (human)" EXACT [UniProtKB:O15105]
synonym: "MAD homolog 7 (human)" EXACT [UniProtKB:O15105]
synonym: "MAD homolog 8 (human)" EXACT [UniProtKB:O15105]
synonym: "SMAD family member 7 (human)" EXACT [UniProtKB:O15105]
synonym: "mothers against DPP homolog 7 (human)" EXACT [UniProtKB:O15105]
synonym: "mothers against DPP homolog 8 (human)" EXACT [UniProtKB:O15105]
synonym: "mothers against decapentaplegic homolog 8 (human)" EXACT [UniProtKB:O15105]
xref: Reactome:R-HSA-173478 "PR:O15105 located_in GO:0005829"
xref: Reactome:R-HSA-178197 "PR:O15105 located_in GO:0005654"
xref: UniProtKB:O15105
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000374 ! smad7
relationship: has_gene_template HGNC:6773 ! SMAD7 (human)

[Term]
id: PR:000000481
name: smad7 isoform 1
def: "A smad7 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O35253-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "SMAD7/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000374 ! smad7

[Term]
id: PR:000000374
name: smad7
def: "An inhibitory smad protein that is a translation product of the human SMAD7 gene or a 1:1 ortholog thereof. Smad7 is a negative regulator of TGF-beta signaling." [PMID:17438144]
comment: Category=gene.
synonym: "MADH7" RELATED Gene-based []
synonym: "MADH8" RELATED Gene-based []
synonym: "SMAD7" EXACT PRO-short-label [PRO:DNx]
synonym: "SMAD 7" EXACT []
synonym: "MAD homolog 7" EXACT []
synonym: "MAD homolog 8" EXACT []
synonym: "SMAD family member 7" EXACT []
synonym: "mothers against DPP homolog 7" EXACT []
synonym: "mothers against DPP homolog 8" EXACT []
synonym: "mothers against decapentaplegic homolog 8" EXACT []
is_a: PR:000000099 ! inhibitory smad protein

[Term]
id: PR:000000664
name: smad7 isoform 1 phosphorylated 1
def: "A smad7 isoform 1 phosphorylated form in which the phosphorylation occurs at the Ser residue within the DSQL sequence region in the MH2 domain. Example: UniProtKB:O15105-1, Ser-249, MOD:00046." [PRO:CNA]
comment: Category=modification.
synonym: "SMAD7/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000583 ! smad7 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000000665
name: smad7 isoform 1 ubiquitinated 1
def: "A smad7 isoform 1 ubiquitinated form that has been ubiquitinated at Lys residues within the MH1 domain by Smurf proteins. This targets smad7 for proteosomal degradation." [PMID:12408818]
comment: Category=modification.
synonym: "SMAD7/iso:1/Ubiq:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000584 ! smad7 isoform 1 ubiquitinated form
relationship: has_part MOD:01148 ! ubiquitinylated lysine

[Term]
id: PR:000000663
name: smad7 isoform 1 acetylated 1
def: "A smad7 isoform 1 acetylated form that has been acetylated at Lys residues within the MH1 domain by Histone acetyltransferase p300. Example: UniProtKB:O15105-1, Lys-64/Lys-70, MOD:00064." [PMID:12408818]
comment: Category=modification. Note: Acetylation stabilizes smad7.
synonym: "SMAD7/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000582 ! smad7 isoform 1 acetylated form
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000036932
name: smad7 isoform 1 phosphorylated 1 (mouse)
def: "A smad7 isoform 1 phosphorylated 1 in mouse. UniProtKB:O35253-1, Ser-249, MOD:00046." [PMID:11278814, PRO:CNA]
comment: Category=organism-modification.
synonym: "mSMAD7/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O35253-1, Ser-249, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000664 ! smad7 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000038037
name: smad7 isoform 3
def: "A smad7 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15105-3 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "SMAD7/iso:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000374 ! smad7

[Term]
id: PR:O35253-2
name: mothers against decapentaplegic homolog 7 isoform B (mouse)
def: "A smad7 isoform 3 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mSMAD7/iso:B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O35253-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038037 ! smad7 isoform 3

[Term]
id: PR:O35253-1
name: mothers against decapentaplegic homolog 7 isoform A (mouse)
def: "A smad7 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mSMAD7/iso:A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O35253-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000481 ! smad7 isoform 1

[Term]
id: PR:000036566
name: smad7 isoform 1 phosphorylated 1 (human)
def: "A smad7 isoform 1 phosphorylated 1 in human. UniProtKB:O15105-1, Ser-249, MOD:00046." [PRO:CNA]
comment: Category=organism-modification. Evidence:(ECO:0000250, based on PR:000036932).
synonym: "hSMAD7/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O15105-1, Ser-249, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000664 ! smad7 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000036565
name: smad7 isoform 1 acetylated 1 (human)
def: "A smad7 isoform 1 acetylated 1 in human. UniProtKB:O15105-1, Lys-64/Lys-70, MOD:00064." [PMID:12408818, PRO:CNA]
comment: Category=organism-modification.
synonym: "hSMAD7/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O15105-1, Lys-64/Lys-70, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000663 ! smad7 isoform 1 acetylated 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine