[Term]
id: PR:O43541-4
name: mothers against decapentaplegic homolog 6 isoform D (human)
def: "A mothers against decapentaplegic homolog 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43541-4." [PRO:DNx, UniProtKB:O43541]
comment: Category=organism-sequence.
synonym: "hSMAD6/iso:D" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O43541-4
is_a: PR:O43541 ! mothers against decapentaplegic homolog 6 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O43541-1
name: mothers against decapentaplegic homolog 6 isoform A (human)
def: "A smad6 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSMAD6/iso:A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O43541-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000479 ! smad6 isoform 1

[Term]
id: PR:O43541-2
name: mothers against decapentaplegic homolog 6 isoform B (human)
def: "A smad6 isoform 2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSMAD6/iso:B" EXACT PRO-short-label [PRO:DNx]
synonym: "mothers against decapentaplegic homolog 6 isoform Smad 6S (human)" EXACT [UniProtKB:O43541]
xref: UniProtKB:O43541-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000480 ! smad6 isoform 2

[Term]
id: PR:O35182-1
name: mothers against decapentaplegic homolog 6 isoform 1 (mouse)
def: "A smad6 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mSMAD6/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O35182-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000479 ! smad6 isoform 1

[Term]
id: PR:000000581
name: smad6 isoform 1 dimethylated form
def: "A smad6 isoform 1 that includes at least one dimethylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "SMAD6/iso:1/Me2Res+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00429 ! dimethylated residue
intersection_of: PR:000000479 ! smad6 isoform 1

[Term]
id: PR:000000662
name: smad6 isoform 1 dimethylated 1
def: "A smad6 isoform 1 dimethylated form that has been dimethylated at Arg residues within the MH1 domain by PRMT1. Example: UniProtKB:O35182-1, Arg-74, MOD:00783." [PMID:17118358]
comment: Category=modification.
synonym: "SMAD6/iso:1/Me2:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000581 ! smad6 isoform 1 dimethylated form
relationship: has_part MOD:00783 ! dimethylated L-arginine

[Term]
id: PR:000000479
name: smad6 isoform 1
def: "A smad6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43541-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "SMAD6/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000373 ! smad6

[Term]
id: PR:000000480
name: smad6 isoform 2
def: "A smad6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43541-2 or a 1:1 ortholog thereof." [PMID:11284962, PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "smad6s" RELATED []
synonym: "SMAD6/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "smad6 isoform B" RELATED []
synonym: "smad6 short isoform" RELATED []
is_a: PR:000000373 ! smad6

[Term]
id: PR:000000373
name: smad6
def: "An inhibitory smad protein that is a translation product of the human SMAD6 gene or a 1:1 ortholog thereof. Inhibitor of bone morphogenetic protein (BMP) signaling, and the interaction with BMP type 1 receptors is a critical step in the function of smad6." [PMID:17493940]
comment: Category=gene.
synonym: "MADH6" RELATED Gene-based []
synonym: "Madh7" RELATED Gene-based []
synonym: "SMAD6" EXACT PRO-short-label [PRO:DNx]
synonym: "Msmad6" RELATED Gene-based []
synonym: "SMAD 6" EXACT []
synonym: "MAD homolog 6" EXACT []
synonym: "Mad homolog 7" EXACT []
synonym: "SMAD family member 6" EXACT []
synonym: "mothers against DPP homolog 6" EXACT []
is_a: PR:000000099 ! inhibitory smad protein

[Term]
id: PR:O35182
name: mothers against decapentaplegic homolog 6 (mouse)
def: "A smad6 that is encoded in the genome of mouse." [OMA:O35182, PRO:DNx]
comment: Category=organism-gene.
synonym: "Madh6" RELATED Gene-based [UniProtKB:O35182]
synonym: "Madh7" RELATED Gene-based [UniProtKB:O35182]
synonym: "Smad6" RELATED Gene-based [UniProtKB:O35182]
synonym: "Msmad6" RELATED Gene-based [UniProtKB:O35182]
synonym: "mSMAD6" EXACT PRO-short-label [PRO:DNx]
synonym: "SMAD 6 (mouse)" EXACT [UniProtKB:O35182]
synonym: "MAD homolog 6 (mouse)" EXACT [UniProtKB:O35182]
synonym: "Mad homolog 7 (mouse)" EXACT [UniProtKB:O35182]
synonym: "SMAD family member 6 (mouse)" EXACT [UniProtKB:O35182]
synonym: "mothers against DPP homolog 6 (mouse)" EXACT [UniProtKB:O35182]
xref: UniProtKB:O35182
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000373 ! smad6
relationship: has_gene_template MGI:1336883 ! Smad6 (mouse)

[Term]
id: PR:Q9W734
name: mothers against decapentaplegic homolog 6 (chicken)
def: "A smad6 that is encoded in the genome of chicken." [OMA:Q9W734, PRO:DNx]
comment: Category=organism-gene.
synonym: "MADH6" RELATED Gene-based [UniProtKB:Q9W734]
synonym: "SMAD6" RELATED Gene-based [UniProtKB:Q9W734]
synonym: "chick-SMAD6" EXACT PRO-short-label [PRO:DNx]
synonym: "Smad6 (chicken)" EXACT [UniProtKB:Q9W734]
synonym: "SMAD 6 (chicken)" EXACT [UniProtKB:Q9W734]
synonym: "MAD homolog 6 (chicken)" EXACT [UniProtKB:Q9W734]
synonym: "SMAD family member 6 (chicken)" EXACT [UniProtKB:Q9W734]
synonym: "mothers against DPP homolog 6 (chicken)" EXACT [UniProtKB:Q9W734]
xref: UniProtKB:Q9W734
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000000373 ! smad6
relationship: has_gene_template CGNC:66183 ! SMAD6 (chicken)

[Term]
id: PR:O43541
name: mothers against decapentaplegic homolog 6 (human)
def: "A smad6 that is encoded in the genome of human." []
comment: Category=organism-gene.
synonym: "MADH6" RELATED Gene-based [UniProtKB:O43541]
synonym: "SMAD6" RELATED Gene-based [UniProtKB:O43541]
synonym: "hSMAD6" EXACT PRO-short-label [PRO:DNx]
synonym: "Smad6 (human)" EXACT [UniProtKB:O43541]
synonym: "SMAD 6 (human)" EXACT [UniProtKB:O43541]
synonym: "MAD homolog 6 (human)" EXACT [UniProtKB:O43541]
synonym: "SMAD family member 6 (human)" EXACT [UniProtKB:O43541]
synonym: "mothers against DPP homolog 6 (human)" EXACT [UniProtKB:O43541]
xref: Reactome:R-HSA-3006350 "PR:O43541 located_in GO:0005829"
xref: UniProtKB:O43541
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000373 ! smad6
relationship: has_gene_template HGNC:6772 ! SMAD6 (human)

[Term]
id: PR:000036564
name: smad6 isoform 1 dimethylated 1 (mouse)
def: "A smad6 isoform 1 dimethylated 1 in mouse. UniProtKB:O35182-1, Arg-74, MOD:00783." [PMID:17118358, PRO:CNA]
comment: Category=organism-modification.
synonym: "mSMAD6/iso:1/Me2:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O35182-1, Arg-74, MOD:00783" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000662 ! smad6 isoform 1 dimethylated 1
relationship: has_part MOD:00783 ! dimethylated L-arginine