[Term]
id: PR:000048185
name: left-right determination factor 2, signal peptide removed form (human)
def: "A left-right determination factor 2 (human) that has had the signal peptide removed. UniProtKB:O00292, 22-366." [PRO:DNx, Reactome:R-HSA-114708]
comment: Category=organism-modification.
synonym: "hLEFTY2/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O00292, 22-366" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-114708 "PR:000048185 located_in GO:0005576"
intersection_of: PR:O00292 ! left-right determination factor 2 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000452
name: lefty 2 sequence variant S342N (human)
def: "A left-right determination factor 2 (human) that has an Asn residue at the position equivalent to Ser-342 of the amino acid sequence represented by UniProtKB:O00292-1. Example: UniProtKB:O00292-1, Ser-342, CHEBI:50347." [PMID:10053005, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hLEFTY2/var:S342N" EXACT PRO-short-label [PRO:DNx]
synonym: "lefty 2 sequence variant 1 (human)" EXACT [PRO:DNx]
synonym: "UniProtKB:O00292-1, Ser-342, CHEBI:50347" NARROW PRO-proteoform-std [PRO:DAN]
xref: UniProtKB_VAR:VAR_010385
is_a: PR:O00292 ! left-right determination factor 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O00292-1
name: left-right determination factor 2 isoform 1 (human)
def: "A lefty 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hLEFTY2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O00292-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000451 ! lefty 2 isoform 1

[Term]
id: PR:000000288
name: lefty 2
def: "A lefty protein that is a translation product of the human LEFTY2 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "EBAF" RELATED Gene-based []
synonym: "LEFTA" RELATED Gene-based []
synonym: "Leftb" RELATED []
synonym: "TGFB4" RELATED Gene-based []
synonym: "LEFTY2" EXACT PRO-short-label [PRO:DNx]
synonym: "LEFTYA" RELATED Gene-based []
synonym: "PSEC0024" RELATED Gene-based []
synonym: "TGF-beta-4" RELATED []
synonym: "protein lefty-2" EXACT []
synonym: "protein lefty-A" EXACT []
synonym: "protein lefty-B" RELATED []
synonym: "left-right determination factor A" EXACT []
synonym: "left-right determination factor B" RELATED []
synonym: "transforming growth factor beta-4" RELATED []
synonym: "endometrial bleeding-associated factor" EXACT []
is_a: PR:000000102 ! lefty protein

[Term]
id: PR:O00292-2
name: left-right determination factor 2 isoform h2 (human)
def: "A left-right determination factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00292-2." [PRO:DNx, UniProtKB:O00292]
comment: Category=organism-sequence.
synonym: "hLEFTY2/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O00292-2
is_a: PR:O00292 ! left-right determination factor 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O00292
name: left-right determination factor 2 (human)
def: "A lefty 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O00292]
comment: Category=organism-gene.
synonym: "EBAF" RELATED Gene-based [UniProtKB:O00292]
synonym: "LEFTA" RELATED Gene-based [UniProtKB:O00292]
synonym: "TGFB4" RELATED Gene-based [UniProtKB:O00292]
synonym: "LEFTY2" RELATED Gene-based [UniProtKB:O00292]
synonym: "LEFTYA" RELATED Gene-based [UniProtKB:O00292]
synonym: "hLEFTY2" EXACT PRO-short-label [PRO:DNx]
synonym: "PSEC0024" RELATED Gene-based [UniProtKB:O00292]
synonym: "TGF-beta-4 (human)" EXACT [UniProtKB:O00292]
synonym: "protein lefty-2 (human)" EXACT [UniProtKB:O00292]
synonym: "protein lefty-A (human)" EXACT [UniProtKB:O00292]
synonym: "left-right determination factor A (human)" EXACT [UniProtKB:O00292]
synonym: "transforming growth factor beta-4 (human)" EXACT [UniProtKB:O00292]
synonym: "endometrial bleeding-associated factor (human)" EXACT [UniProtKB:O00292]
xref: UniProtKB:O00292
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000288 ! lefty 2
relationship: has_gene_template HGNC:3122 ! LEFTY2 (human)

[Term]
id: PR:000036549
name: lefty 2 isoform 1 cleaved 1 (human)
def: "A lefty 2 isoform 1 cleaved 1 in human. UniProtKB:O00292-1, 77-366." [PMID:10053005, PMID:11278322, PRO:CNA]
comment: Category=organism-modification.
synonym: "PRO_0000033807" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hLEFTY2/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O00292-1, 77-366" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-65944 "PR:000036549 located_in GO:0031093"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000645 ! lefty 2 isoform 1 cleaved 1

[Term]
id: PR:000036550
name: lefty 2 isoform 1 cleaved 2 (human)
def: "A lefty 2 isoform 1 cleaved 2 in human. UniProtKB:O00292-1, 135-366." [PMID:11278322, PRO:CNA]
comment: Category=organism-modification.
synonym: "hLEFTY2/iso:1/Clv:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O00292-1, 135-366" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000646 ! lefty 2 isoform 1 cleaved 2