[Term]
id: PR:000000450
name: lefty 1 isoform 1
def: "A lefty 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75610-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "LEFTY1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000287 ! lefty 1

[Term]
id: PR:000000287
name: lefty 1
def: "A lefty protein that is a translation product of the human LEFTY1 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "Ebaf" RELATED []
synonym: "LEFTB" RELATED Gene-based []
synonym: "Lefty" RELATED []
synonym: "Stra3" RELATED []
synonym: "Tgfb4" RELATED []
synonym: "LEFTY1" EXACT PRO-short-label [PRO:DNx]
synonym: "LEFTYB" RELATED Gene-based []
synonym: "TGF-beta-4" RELATED []
synonym: "UNQ278/PRO317" RELATED Gene-based []
synonym: "lefty protein" BROAD [PRO:DNx]
synonym: "protein lefty-1" EXACT []
synonym: "protein lefty-B" RELATED []
synonym: "left-right determination factor B" RELATED []
synonym: "transforming growth factor beta-4" RELATED []
synonym: "stimulated by retinoic acid gene 3 protein" EXACT []
is_a: PR:000000102 ! lefty protein

[Term]
id: PR:000000643
name: lefty 1 isoform 1 cleaved 1
def: "A lefty 1 isoform 1 that is the C-terminal part after processing by proteolytic cleavage at the first dibasic RxxR cleavage site within the propeptide region." [PMID:11278322, PMID:18039650]
comment: Category=modification.
synonym: "LEFTY1/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000450 ! lefty 1 isoform 1
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:000025431
name: lefty 1 proteolytic cleavage product
def: "A lefty 1 that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "LEFTY1/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000000287 ! lefty 1

[Term]
id: PR:000000644
name: lefty 1 isoform 1 cleaved 2
def: "A lefty 1 isoform 1 that is the C-terminal part after processing by proteolytic cleavage at the second dibasic RxxR cleavage site within the propeptide region." [PMID:11278322]
comment: Category=modification.
synonym: "LEFTY1/iso:1/Clv:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000450 ! lefty 1 isoform 1
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:O75610
name: left-right determination factor 1 (human)
def: "A lefty 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O75610]
comment: Category=organism-gene.
synonym: "LEFTB" RELATED Gene-based [UniProtKB:O75610]
synonym: "LEFTY1" RELATED Gene-based [UniProtKB:O75610]
synonym: "LEFTYB" RELATED Gene-based [UniProtKB:O75610]
synonym: "hLEFTY1" EXACT PRO-short-label [PRO:DNx]
synonym: "UNQ278/PRO317" RELATED Gene-based [UniProtKB:O75610]
synonym: "protein lefty-1 (human)" EXACT [UniProtKB:O75610]
synonym: "protein lefty-B (human)" EXACT [UniProtKB:O75610]
synonym: "left-right determination factor B (human)" EXACT [UniProtKB:O75610]
xref: UniProtKB:O75610
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000287 ! lefty 1
relationship: has_gene_template HGNC:6552 ! LEFTY1 (human)

[Term]
id: PR:000036548
name: lefty 1 isoform 1 cleaved 2 (human)
def: "A lefty 1 isoform 1 cleaved 2 in human. UniProtKB:O75610-1, 135-366." [PMID:11278322, PRO:CNA]
comment: Category=organism-modification.
synonym: "hLEFTY1/iso:1/Clv:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O75610-1, 135-366" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000644 ! lefty 1 isoform 1 cleaved 2

[Term]
id: PR:O75610-1
name: left-right determination factor 1 isoform 1 (human)
def: "A lefty 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hLEFTY1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O75610-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000450 ! lefty 1 isoform 1

[Term]
id: PR:000036546
name: lefty 1 isoform 1 cleaved 1 (human)
def: "A lefty 1 isoform 1 cleaved 1 in human. UniProtKB:O75610-1, 77-366." [PMID:11278322, PRO:CNA]
comment: Category=organism-modification.
synonym: "PRO_0000033811" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hLEFTY1/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O75610-1, 77-366" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1181326 "PR:000036546 located_in GO:0005576"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000643 ! lefty 1 isoform 1 cleaved 1

[Term]
id: PR:000036547
name: lefty 1 isoform 1 cleaved 1 (mouse)
def: "A lefty 1 isoform 1 cleaved 1 in mouse. UniProtKB:Q64280-1, 77-368." [PMID:15004567, PMID:18039650, PRO:CNA]
comment: Category=organism-modification.
synonym: "PRO_0000033809" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "mLEFTY1/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q64280-1, 77-368" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000643 ! lefty 1 isoform 1 cleaved 1

[Term]
id: PR:Q64280-1
name: left-right determination factor 1 isoform 1 (mouse)
def: "A lefty 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mLEFTY1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q64280-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000450 ! lefty 1 isoform 1