[Term]
id: PR:000000441
name: growth/differentiation factor 5 sequence variant 5 (mouse)
def: "A growth/differentiation factor 5 (mouse) that has a frameshift at the position equivalent to residue 376 of the amino acid sequence represented by UniProtKB:P43027." [PMID:8145850, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence. Note: Variant was found in a derivative of the A/J strain.
synonym: "mGDF5/var:5" EXACT PRO-short-label [PRO:DNx]
is_a: PR:P43027 ! growth/differentiation factor 5 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000000437
name: growth/differentiation factor 5 sequence variant C400Y (human)
def: "A growth/differentiation factor 5 (human) that has a Tyr residue at the position equivalent to Cys-400 of the amino acid sequence represented by UniProtKB:P43026. UniProtKB:P43026, Cys-400, CHEBI:46858." [PMID:9288098, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hGDF5/var:C400Y" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43026, Cys-400, CHEBI:46858" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "growth/differentiation factor 5 sequence variant 1 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_017407
is_a: PR:P43026 ! growth/differentiation factor 5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000281
name: growth/differentiation factor 5
def: "A growth/differentiation factor that is a translation product of the human GDF5 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "Bp" RELATED Gene-based []
synonym: "GDF5" EXACT PRO-short-label [PRO:DNx]
synonym: "BMP14" RELATED Gene-based []
synonym: "CDMP1" RELATED Gene-based []
synonym: "GDF-5" EXACT []
synonym: "BMP-14" EXACT []
synonym: "CDMP-1" EXACT []
synonym: "radotermin" EXACT []
synonym: "bone morphogenetic protein 14" EXACT []
synonym: "cartilage-derived morphogenetic protein 1" EXACT []
xref: PANTHER:PTHR11848:SF44
is_a: PR:000000098 ! growth/differentiation factor

[Term]
id: PR:000036417
name: growth/differentiation factor 5 sequence variant V186* (mouse)
def: "A growth/differentiation factor 5 (mouse) that has a polypeptide truncation after the position equivalent to residue 185 of the amino acid sequence represented by UniProtKB:P43027. UniProtKB:P43027, 1-185." [PMID:8145850, PRO:CNA]
comment: Category=organism-sequence.
synonym: "bp-3J (mouse)" RELATED []
synonym: "mGDF5/var:V186*" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43027, 1-185" EXACT PRO-proteoform-std [PRO:DAN]
is_a: PR:P43027 ! growth/differentiation factor 5 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000000640
name: growth/differentiation factor 5 isoform 1 cleaved 1
def: "A growth/differentiation factor 5 isoform 1, signal peptide removed form that has been processed by subsequent removal of the propeptide, yielding the mature protein. The functional unit is a dimer." [PMID:8962721, PRO:CNA]
comment: Category=modification.
synonym: "GDF5/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000021914 ! growth/differentiation factor 5 isoform 1, signal peptide removed form
intersection_of: lacks_part SO:0001062 ! propeptide

[Term]
id: PR:000000439
name: growth/differentiation factor 5 sequence variant L441P (human)
def: "A growth/differentiation factor 5 (human) that has a Pro residue at the position equivalent to Leu-441 of the amino acid sequence represented by UniProtKB:P43026. UniProtKB:P43026, Leu-441, CHEBI:50342." [PMID:12121354, PMID:16127465, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hGDF5/var:L441P" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43026, Leu-441, CHEBI:50342" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "growth/differentiation factor 5 sequence variant 3 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_017408
is_a: PR:P43026 ! growth/differentiation factor 5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000438
name: growth/differentiation factor 5 sequence variant R438L (human)
def: "A growth/differentiation factor 5 (human) that has a Leu residue at the position equivalent to Arg-438 of the amino acid sequence represented by UniProtKB:P43026. UniProtKB:P43026, Arg-438, CHEBI:30006." [PMID:16532400, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hGDF5/var:R438L" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43026, Arg-438, CHEBI:30006" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "growth/differentiation factor 5 sequence variant 2 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_026545
is_a: PR:P43026 ! growth/differentiation factor 5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q5KSY1
name: growth and differentiation factor-5 (rat)
def: "A growth/differentiation factor 5 that is encoded in the genome of rat." [PANTHER:PTHR11848:SF44, PRO:DNx]
comment: Category=organism-gene.
synonym: "rGDF5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q5KSY1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000281 ! growth/differentiation factor 5
relationship: has_gene_template RGD:620102 ! Gdf5 (rat)

[Term]
id: PR:P43027
name: growth/differentiation factor 5 (mouse)
def: "A growth/differentiation factor 5 that is encoded in the genome of mouse." [OMA:P43027, PRO:DNx]
comment: Category=organism-gene.
synonym: "Bp" RELATED Gene-based [UniProtKB:P43027]
synonym: "Gdf5" RELATED Gene-based [UniProtKB:P43027]
synonym: "Bmp14" RELATED Gene-based [UniProtKB:P43027]
synonym: "Gdf-5" RELATED Gene-based [UniProtKB:P43027]
synonym: "mGDF5" EXACT PRO-short-label [PRO:DNx]
synonym: "GDF-5 (mouse)" EXACT [UniProtKB:P43027]
synonym: "BMP-14 (mouse)" EXACT [UniProtKB:P43027]
synonym: "bone morphogenetic protein 14 (mouse)" EXACT [UniProtKB:P43027]
xref: UniProtKB:P43027
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000281 ! growth/differentiation factor 5
relationship: has_gene_template MGI:95688 ! Gdf5 (mouse)

[Term]
id: PR:000021929
name: growth/differentiation factor 5 proteolytic cleavage product
def: "A growth/differentiation factor 5 that has been processed by proteolytic cleavage." [PRO:DAN]
comment: Category=modification.
synonym: "GDF5/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000000281 ! growth/differentiation factor 5

[Term]
id: PR:000000436
name: growth/differentiation factor 5 isoform 1
def: "A growth/differentiation factor 5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P43026-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "GDF5/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000281 ! growth/differentiation factor 5

[Term]
id: PR:P43027-1
name: growth/differentiation factor 5 isoform 1 (mouse)
def: "A growth/differentiation factor 5 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mGDF5/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P43027-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000436 ! growth/differentiation factor 5 isoform 1

[Term]
id: PR:000047523
name: growth/differentiation factor 5, signal peptide removed form (human)
def: "A growth/differentiation factor 5 (human) that has had the signal peptide removed. UniProtKB:P43026, 28-501." [PRO:DNx, Reactome:R-HSA-2396129]
comment: Category=organism-modification.
synonym: "hGDF5/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43026, 28-501" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2396129 "PR:000047523 located_in GO:0005576"
intersection_of: PR:P43026 ! growth/differentiation factor 5 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000021914
name: growth/differentiation factor 5 isoform 1, signal peptide removed form
def: "A growth/differentiation factor 5 isoform 1 that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "GDF5/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000000436 ! growth/differentiation factor 5 isoform 1
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:P43026-1
name: growth/differentiation factor 5 isoform 1 (human)
def: "A growth/differentiation factor 5 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hGDF5/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P43026-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000436 ! growth/differentiation factor 5 isoform 1

[Term]
id: PR:P43026
name: growth/differentiation factor 5 (human)
def: "A growth/differentiation factor 5 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P43026]
comment: Category=organism-gene.
synonym: "GDF5" RELATED Gene-based [UniProtKB:P43026]
synonym: "BMP14" RELATED Gene-based [UniProtKB:P43026]
synonym: "CDMP1" RELATED Gene-based [UniProtKB:P43026]
synonym: "hGDF5" EXACT PRO-short-label [PRO:DNx]
synonym: "GDF-5 (human)" EXACT [UniProtKB:P43026]
synonym: "LAP-4 (human)" EXACT [UniProtKB:P43026]
synonym: "BMP-14 (human)" EXACT [UniProtKB:P43026]
synonym: "CDMP-1 (human)" EXACT [UniProtKB:P43026]
synonym: "radotermin (human)" EXACT [UniProtKB:P43026]
synonym: "LPS-associated protein 4 (human)" EXACT [UniProtKB:P43026]
synonym: "bone morphogenetic protein 14 (human)" EXACT [UniProtKB:P43026]
synonym: "lipopolysaccharide-associated protein 4 (human)" EXACT [UniProtKB:P43026]
synonym: "cartilage-derived morphogenetic protein 1 (human)" EXACT [UniProtKB:P43026]
xref: UniProtKB:P43026
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000281 ! growth/differentiation factor 5
relationship: has_gene_template HGNC:4220 ! GDF5 (human)

[Term]
id: PR:000036543
name: growth/differentiation factor 5 isoform 1 cleaved 1 (human)
def: "A growth/differentiation factor 5 isoform 1 cleaved 1 in human. UniProtKB:P43026-1, 382-501." [PMID:15752764, PMID:15890363, PMID:16532400, PMID:8589725, PMID:8962721, PMID:9288098, PRO:CNA]
comment: Category=organism-modification.
synonym: "PRO_0000033913" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hGDF5/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43026-1, 382-501" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000640 ! growth/differentiation factor 5 isoform 1 cleaved 1