[Term]
id: PR:000000437
name: growth/differentiation factor 5 sequence variant C400Y (human)
def: "A growth/differentiation factor 5 (human) that has a Tyr residue at the position equivalent to Cys-400 of the amino acid sequence represented by UniProtKB:P43026. UniProtKB:P43026, Cys-400, CHEBI:46858." [PMID:9288098, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hGDF5/var:C400Y" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43026, Cys-400, CHEBI:46858" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "growth/differentiation factor 5 sequence variant 1 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_017407
is_a: PR:P43026 ! growth/differentiation factor 5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000281
name: growth/differentiation factor 5
def: "A growth/differentiation factor that is a translation product of the human GDF5 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "Bp" RELATED Gene-based []
synonym: "GDF5" EXACT PRO-short-label [PRO:DNx]
synonym: "BMP14" RELATED Gene-based []
synonym: "CDMP1" RELATED Gene-based []
synonym: "GDF-5" EXACT []
synonym: "BMP-14" EXACT []
synonym: "CDMP-1" EXACT []
synonym: "radotermin" EXACT []
synonym: "bone morphogenetic protein 14" EXACT []
synonym: "cartilage-derived morphogenetic protein 1" EXACT []
xref: PANTHER:PTHR11848:SF44
is_a: PR:000000098 ! growth/differentiation factor

[Term]
id: PR:P43026
name: growth/differentiation factor 5 (human)
def: "A growth/differentiation factor 5 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P43026]
comment: Category=organism-gene.
synonym: "GDF5" RELATED Gene-based [UniProtKB:P43026]
synonym: "BMP14" RELATED Gene-based [UniProtKB:P43026]
synonym: "CDMP1" RELATED Gene-based [UniProtKB:P43026]
synonym: "hGDF5" EXACT PRO-short-label [PRO:DNx]
synonym: "GDF-5 (human)" EXACT [UniProtKB:P43026]
synonym: "LAP-4 (human)" EXACT [UniProtKB:P43026]
synonym: "BMP-14 (human)" EXACT [UniProtKB:P43026]
synonym: "CDMP-1 (human)" EXACT [UniProtKB:P43026]
synonym: "radotermin (human)" EXACT [UniProtKB:P43026]
synonym: "LPS-associated protein 4 (human)" EXACT [UniProtKB:P43026]
synonym: "bone morphogenetic protein 14 (human)" EXACT [UniProtKB:P43026]
synonym: "lipopolysaccharide-associated protein 4 (human)" EXACT [UniProtKB:P43026]
synonym: "cartilage-derived morphogenetic protein 1 (human)" EXACT [UniProtKB:P43026]
xref: UniProtKB:P43026
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000281 ! growth/differentiation factor 5
relationship: has_gene_template HGNC:4220 ! GDF5 (human)

[Term]
id: PR:000000439
name: growth/differentiation factor 5 sequence variant L441P (human)
def: "A growth/differentiation factor 5 (human) that has a Pro residue at the position equivalent to Leu-441 of the amino acid sequence represented by UniProtKB:P43026. UniProtKB:P43026, Leu-441, CHEBI:50342." [PMID:12121354, PMID:16127465, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hGDF5/var:L441P" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43026, Leu-441, CHEBI:50342" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "growth/differentiation factor 5 sequence variant 3 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_017408
is_a: PR:P43026 ! growth/differentiation factor 5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000438
name: growth/differentiation factor 5 sequence variant R438L (human)
def: "A growth/differentiation factor 5 (human) that has a Leu residue at the position equivalent to Arg-438 of the amino acid sequence represented by UniProtKB:P43026. UniProtKB:P43026, Arg-438, CHEBI:30006." [PMID:16532400, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hGDF5/var:R438L" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43026, Arg-438, CHEBI:30006" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "growth/differentiation factor 5 sequence variant 2 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_026545
is_a: PR:P43026 ! growth/differentiation factor 5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000047523
name: growth/differentiation factor 5, signal peptide removed form (human)
def: "A growth/differentiation factor 5 (human) that has had the signal peptide removed. UniProtKB:P43026, 28-501." [PRO:DNx, Reactome:R-HSA-2396129]
comment: Category=organism-modification.
synonym: "hGDF5/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43026, 28-501" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2396129 "PR:000047523 located_in GO:0005576"
intersection_of: PR:P43026 ! growth/differentiation factor 5 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P43026-1
name: growth/differentiation factor 5 isoform 1 (human)
def: "A growth/differentiation factor 5 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hGDF5/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P43026-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000436 ! growth/differentiation factor 5 isoform 1

[Term]
id: PR:000036543
name: growth/differentiation factor 5 isoform 1 cleaved 1 (human)
def: "A growth/differentiation factor 5 isoform 1 cleaved 1 in human. UniProtKB:P43026-1, 382-501." [PMID:15752764, PMID:15890363, PMID:16532400, PMID:8589725, PMID:8962721, PMID:9288098, PRO:CNA]
comment: Category=organism-modification.
synonym: "PRO_0000033913" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hGDF5/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43026-1, 382-501" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000640 ! growth/differentiation factor 5 isoform 1 cleaved 1