[Term]
id: PR:000000633
name: TGF-beta 2 isoform B cleaved 2
def: "A TGF-beta 2 isoform B, signal peptide removed form that has been processed by subsequent cleavage at the dibasic cleavage site rendering the latency associated peptide (LAP) and the mature protein non-covalently bound." [PMID:1777240]
comment: Category=modification.
synonym: "TGFB2/iso:B/Clv:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000021909 ! TGF-beta 2 isoform B, signal peptide removed form
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:000000632
name: TGF-beta 2 isoform B cleaved 1
def: "A TGF-beta 2 isoform B that has been processed by proteolytic cleavage and released from the latent complex. This form is the active mature peptide." [PMID:1777240]
comment: Category=modification.
synonym: "TGFB2/iso:B/Clv:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000405 ! TGF-beta 2 isoform B
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:000000631
name: TGF-beta 2 isoform A cleaved 3
def: "A TGF-beta 2 isoform A, signal peptide removed form that has been processed by subsequent cleavage at the dibasic cleavage site rendering the latency associated peptide (LAP) and the mature protein non-covalently bound." [PMID:10224129]
comment: Category=modification.
synonym: "TGFB2/iso:A/Clv:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000021908 ! TGF-beta 2 isoform A, signal peptide removed form
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:000000630
name: TGF-beta 2 isoform A cleaved 2
def: "A TGF-beta 2 isoform A, signal peptide removed form that has been processed by subsequent removal of the C-terminal mature protein. This chain is referred as to the latency associated peptide (LAP)." [PRO:CNA]
comment: Category=modification.
synonym: "TGFB2/iso:A/Clv:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000021908 ! TGF-beta 2 isoform A, signal peptide removed form
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:P61812-1
name: transforming growth factor beta-2 isoform A (human)
def: "A TGF-beta 2 isoform A that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hTGFB2/iso:A" EXACT PRO-short-label [PRO:DNx]
synonym: "TGFB2 isoform 1 (human)" EXACT [PRO:DNx]
xref: UniProtKB:P61812-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000404 ! TGF-beta 2 isoform A

[Term]
id: PR:P61812-2
name: transforming growth factor beta-2 isoform B (human)
def: "A TGF-beta 2 isoform B that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hTGFB2/iso:B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P61812-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000405 ! TGF-beta 2 isoform B

[Term]
id: PR:000036532
name: TGF-beta 2 isoform A cleaved 2 (human)
def: "A TGF-beta 2 isoform A cleaved 2 in human. UniProtKB:P61812-1, 20-302." [PMID:3162913, PRO:CNA]
comment: Category=organism-modification.
synonym: "hTGFB2/iso:A/Clv:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P61812-1, 20-302" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2395269 "PR:000036532 located_in GO:0005576"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000630 ! TGF-beta 2 isoform A cleaved 2

[Term]
id: PR:P27090
name: transforming growth factor beta-2 proprotein (mouse)
def: "A TGF-beta 2 that is encoded in the genome of mouse." [OMA:P27090, PRO:DNx]
comment: Category=organism-gene.
synonym: "Tgfb2" RELATED Gene-based [UniProtKB:P27090]
synonym: "mTGFB2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P27090
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000183 ! TGF-beta 2
relationship: has_gene_template MGI:98726 ! Tgfb2 (mouse)

[Term]
id: PR:Q07257
name: transforming growth factor beta-2 proprotein (rat)
def: "A TGF-beta 2 that is encoded in the genome of rat." [PANTHER:PTHR11848:SF33, PRO:DNx]
comment: Category=organism-gene.
synonym: "Tgfb2" RELATED Gene-based [UniProtKB:Q07257]
synonym: "rTGFB2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q07257
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000183 ! TGF-beta 2
relationship: has_gene_template RGD:70491 ! Tgfb2 (rat)

[Term]
id: PR:P27090-1
name: transforming growth factor beta-2 isoform 1 (mouse)
def: "A TGF-beta 2 isoform A that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mTGFB2/iso:A" EXACT PRO-short-label [PRO:DNx]
synonym: "Tgfb2 isoform 1 (mouse)" EXACT [PRO:DNx]
xref: UniProtKB:P27090-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000404 ! TGF-beta 2 isoform A

[Term]
id: PR:P61812
name: transforming growth factor beta-2 (human)
def: "A TGF-beta 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P61812]
comment: Category=organism-gene.
synonym: "TGFB2" RELATED Gene-based [UniProtKB:P61812]
synonym: "hTGFB2" EXACT PRO-short-label [PRO:DNx]
synonym: "G-TSF (human)" EXACT [UniProtKB:P61812]
synonym: "cetermin (human)" EXACT [UniProtKB:P61812]
synonym: "glioblastoma-derived T-cell suppressor factor (human)" EXACT [UniProtKB:P61812]
xref: UniProtKB:P61812
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000183 ! TGF-beta 2
relationship: has_gene_template HGNC:11768 ! TGFB2 (human)

[Term]
id: PR:000036531
name: TGF-beta 2 isoform A cleaved 2 (mouse)
def: "A TGF-beta 2 isoform A cleaved 2 in mouse. UniProtKB:P27090-1, 20-302." [PMID:14985127, PRO:CNA]
comment: Category=organism-modification.
synonym: "mTGFB2/iso:A/Clv:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P27090-1, 20-302" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000630 ! TGF-beta 2 isoform A cleaved 2

[Term]
id: PR:000036530
name: TGF-beta 2 isoform A cleaved 1 (human)
def: "A TGF-beta 2 isoform A cleaved 1 in human. UniProtKB:P61812-1, 303-414." [PMID:15944186, PMID:16227582, PMID:2119582, PMID:3162913, PMID:3476488, PRO:CNA]
comment: Category=organism-modification.
synonym: "PRO_0000033785" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hTGFB2/iso:A/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P61812-1, 303-414" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-65938 "PR:000036530 located_in GO:0031093"
xref: Reactome:R-HSA-114706 "PR:000036530 located_in GO:0005576"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000629 ! TGF-beta 2 isoform A cleaved 1

[Term]
id: PR:000036533
name: TGF-beta 2 isoform A cleaved 3 (human)
def: "A TGF-beta 2 isoform A cleaved 3 in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P61812-1, 20-302, 303-414." [PMID:3162913, PMID:3476488, PRO:CNA]
comment: Category=organism-modification.
synonym: "hTGFB2/iso:A/Clv:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P61812-1, 20-302, 303-414" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000631 ! TGF-beta 2 isoform A cleaved 3

[Term]
id: PR:000018293
name: TGF-beta 2 proteolytic cleavage product
def: "A TGF-beta 2 that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "TGFB2/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000000183 ! TGF-beta 2

[Term]
id: PR:000036535
name: TGF-beta 2 isoform B cleaved 2 (human)
def: "A TGF-beta 2 isoform B cleaved 2 in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P61812-2, 20-330, 331-442." [PMID:1777240, PRO:CNA]
comment: Category=organism-modification.
synonym: "hTGFB2/iso:B/Clv:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P61812-2, 20-330, 331-442" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000633 ! TGF-beta 2 isoform B cleaved 2

[Term]
id: PR:000036534
name: TGF-beta 2 isoform B cleaved 1 (human)
def: "A TGF-beta 2 isoform B cleaved 1 in human. UniProtKB:P61812-2, 331-442." [PMID:1777240, PRO:CNA]
comment: Category=organism-modification.
synonym: "hTGFB2/iso:B/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P61812-2, 331-442" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000632 ! TGF-beta 2 isoform B cleaved 1

[Term]
id: PR:000000629
name: TGF-beta 2 isoform A cleaved 1
def: "A TGF-beta 2 isoform A that has been processed by proteolytic cleavage and released from the latent complex. This form, cross-linked to an identical chain, is the active mature protein." [PMID:3476488]
comment: Category=modification.
synonym: "TGFB2/iso:A/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "TGF-beta 2 mature protein" RELATED []
is_a: PR:000000404 ! TGF-beta 2 isoform A
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:Q07257-1
name: transforming growth factor beta-2 proprotein isoform rTGF-beta2B (rat)
def: "A transforming growth factor beta-2 proprotein (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q07257-1." [PRO:DNx, UniProtKB:Q07257]
comment: Category=organism-sequence.
synonym: "rTGFB2/iso:rTGF-beta2B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q07257-1
is_a: PR:Q07257 ! transforming growth factor beta-2 proprotein (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:000000183
name: TGF-beta 2
def: "A TGF-beta that is a translation product of the human TGFB2 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "G-TSF" EXACT []
synonym: "TGFB2" EXACT PRO-short-label [PRO:DNx]
synonym: "cetermin" EXACT []
synonym: "polyergin" EXACT []
synonym: "TGF-beta-2" EXACT []
synonym: "BSC-1 cell growth inhibitor" EXACT []
synonym: "glioblastoma-derived T-cell suppressor factor" EXACT []
xref: PANTHER:PTHR11848:SF33
is_a: PR:000000046 ! TGF-beta

[Term]
id: PR:000000404
name: TGF-beta 2 isoform A
def: "A TGF-beta 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P61812-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence. Note: This isoform is upregulated in Alzheimer's disease.
synonym: "TGFB2/iso:A" EXACT PRO-short-label [PRO:DNx]
synonym: "TGF-beta 2(414)" RELATED []
synonym: "TGFB2 isoform A" RELATED []
is_a: PR:000000183 ! TGF-beta 2

[Term]
id: PR:000000405
name: TGF-beta 2 isoform B
def: "A TGF-beta 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P61812-2 or a 1:1 ortholog thereof." [PMID:16868931, PMID:1777240, PMID:2850146, PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "TGFB2/iso:B" EXACT PRO-short-label [PRO:DNx]
synonym: "TGF-beta 2(442)" RELATED []
synonym: "TGFB2 isoform B" RELATED []
is_a: PR:000000183 ! TGF-beta 2

[Term]
id: PR:000021908
name: TGF-beta 2 isoform A, signal peptide removed form
def: "A TGF-beta 2 isoform A that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "TGFB2/iso:A/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000000404 ! TGF-beta 2 isoform A
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000021909
name: TGF-beta 2 isoform B, signal peptide removed form
def: "A TGF-beta 2 isoform B that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "TGFB2/iso:B/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000000405 ! TGF-beta 2 isoform B
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:Q07257-2
name: transforming growth factor beta-2 isoform A (rat)
def: "A TGF-beta 2 isoform A that is encoded in the genome of rat." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "rTGFB2/iso:A" EXACT PRO-short-label [PRO:DNx]
synonym: "Tgfb2 isoform TGFbeta2A (rat)" EXACT [PRO:DNx]
xref: UniProtKB:Q07257-2
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000404 ! TGF-beta 2 isoform A