[Term]
id: PR:000051774
name: tumor necrosis factor O-glycosylated 1 (human)
def: "A tumor necrosis factor (human) that has been O-glycosylated at the residue equivalent to Ser-80 of the amino acid sequence represented by UniProtKB:P01375-1, in which the glycan structure is represented by GlyTouCan:G00031MO. Example: UniProtKB:P01375-1, Ser-80, MOD:00002~GNO:G00031MO." [GlyGen:P01375-1, PMID:8631363, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hTNF/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01375-1, Ser-80, MOD:00002~UniCarbKB:4" NARROW [PRO:DNx]
synonym: "UniProtKB:P01375-1, Ser-80, MOD:00002~GNO:G00031MO" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P01375 ! tumor necrosis factor (human)
relationship: has_part GNO:G00031MO ! G00031MO
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000051775
name: tumor necrosis factor O-glycosylated 2 (human)
def: "A tumor necrosis factor (human) that has been O-glycosylated at the residue equivalent to Ser-80 of the amino acid sequence represented by UniProtKB:P01375-1, in which the glycan structure is represented by GlyTouCan:G56682BC. Example: UniProtKB:P01375-1, Ser-80, MOD:00002~GNO:G56682BC." [GlyGen:P01375-1, PMID:8631363, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hTNF/OGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01375-1, Ser-80, MOD:00002~UniCarbKB:8" NARROW [PRO:DNx]
synonym: "UniProtKB:P01375-1, Ser-80, MOD:00002~GNO:G56682BC" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P01375 ! tumor necrosis factor (human)
relationship: has_part GNO:G56682BC ! G56682BC
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000134
name: tumor necrosis factor
def: "A tumor necrosis factor, TNF-like that is a translation product of the human TNF gene or a 1:1 ortholog thereof. Tumour necrosis factor alpha (TNF) is a pleiotropic cytokine that mediates apoptosis, cell proliferation, immunomodulation, inflammation, viral replication, allergy, arthritis, septic shock, insulin resistance, autoimmune diseases, and other pathological conditions. TNF transduces these cellular responses through two distinct receptors: type I, which are expressed on all cell types, and type II, which are expressed only on cells of the immune system and endothelial cells." [PMID:11053079, PRO:CNA]
comment: Category=gene.
synonym: "TNF" EXACT PRO-short-label [PRO:DNx]
synonym: "TNFA" RELATED Gene-based []
synonym: "TNFa" EXACT []
synonym: "TNF-a" EXACT []
synonym: "TNFSF2" RELATED Gene-based []
synonym: "TNF-alpha" EXACT []
synonym: "cachectin" EXACT []
synonym: "tumor necrosis factor alpha" EXACT []
synonym: "tumor necrosis factor ligand superfamily member 2" EXACT []
xref: PIRSF:PIRSF500467
is_a: PR:000000033 ! tumor necrosis factor, TNF-like

[Term]
id: PR:P01375-1
name: tumor necrosis factor isoform 1 (human)
def: "A tumor necrosis factor isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hTNF/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P01375-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000381 ! tumor necrosis factor isoform 1

[Term]
id: PR:000036504
name: tumor necrosis factor isoform 1 cleaved 1 (human)
def: "A tumor necrosis factor isoform 1 cleaved 1 in human. UniProtKB:P01375-1, 77-233." [PMID:14512626, PMID:3856324, PRO:CNA]
comment: Category=organism-modification.
synonym: "PRO_0000034424" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hTNF/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01375-1, 77-233" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-976821 "PR:000036504 located_in GO:0005576"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000604 ! tumor necrosis factor isoform 1 cleaved 1

[Term]
id: PR:P01375
name: tumor necrosis factor (human)
def: "A tumor necrosis factor that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene. Requested by=PubChem.
synonym: "TNF" RELATED Gene-based [UniProtKB:P01375]
synonym: "TNFA" RELATED Gene-based [UniProtKB:P01375]
synonym: "hTNF" EXACT PRO-short-label [PRO:DNx]
synonym: "TNFSF2" RELATED Gene-based [UniProtKB:P01375]
synonym: "TNFa (human)" EXACT [PRO:DAN]
synonym: "TNF-a (human)" EXACT [UniProtKB:P01375]
synonym: "TNF-alpha (human)" EXACT [UniProtKB:P01375]
synonym: "cachectin (human)" EXACT [UniProtKB:P01375]
synonym: "tumor necrosis factor ligand superfamily member 2 (human)" EXACT [UniProtKB:P01375]
xref: Reactome:R-HSA-66220 "PR:P01375 located_in GO:0005886"
xref: UniProtKB:P01375
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000134 ! tumor necrosis factor
relationship: has_gene_template HGNC:11892 ! TNF (human)

[Term]
id: PR:000036507
name: tumor necrosis factor isoform 1 myristoylated 1 (human)
def: "A tumor necrosis factor isoform 1 myristoylated 1 in human. UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087." [PMID:1402651, PRO:CNA]
comment: Category=organism-modification.
synonym: "hTNF/iso:1/Myr:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000606 ! tumor necrosis factor isoform 1 myristoylated 1
relationship: has_part MOD:00087 ! N6-myristoyl-L-lysine

[Term]
id: PR:000036508
name: tumor necrosis factor isoform 1 phosphorylated 1 (human)
def: "A tumor necrosis factor isoform 1 phosphorylated 1 in human. UniProtKB:P01375-1, Ser-2, MOD:00046." [PMID:10205166, PMID:8597870, PRO:CNA]
comment: Category=organism-modification.
synonym: "hTNF/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01375-1, Ser-2, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000607 ! tumor necrosis factor isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine