[Term]
id: PR:000000597
name: transcription factor Sp1 isoform 1 cleaved 1
def: "A transcription factor Sp1 isoform 1 that has had the N-terminal inhibitory domain released." [PMID:16407261]
comment: Category=modification.
synonym: "SP1/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000380 ! transcription factor Sp1 isoform 1
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:000036496
name: transcription factor Sp1 isoform 1 acetylated 1 (human)
def: "A transcription factor Sp1 isoform 1 acetylated 1 in human." [PMID:15647279, PRO:CNA]
comment: Category=organism-modification.
synonym: "hSP1/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000596 ! transcription factor Sp1 isoform 1 acetylated 1
relationship: has_part MOD:00394 ! acetylated residue

[Term]
id: PR:000036497
name: transcription factor Sp1 isoform 1 cleaved 1 (human)
def: "A transcription factor Sp1 isoform 1 cleaved 1 in human. UniProtKB:P08047-1, 65-785." [PMID:16407261, PRO:CNA]
comment: Category=organism-modification.
synonym: "hSP1/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P08047-1, 65-785" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000597 ! transcription factor Sp1 isoform 1 cleaved 1

[Term]
id: PR:000036498
name: transcription factor Sp1 isoform 1 O-glycosylated 1 (human)
def: "A transcription factor Sp1 isoform 1 O-glycosylated 1 in human. UniProtKB:P08047-1, Ser-491, MOD:00805." [PMID:11371615, PMID:9343410, PRO:CNA, PRO:DAN]
comment: Category=organism-modification. Note: The indicated references identify the modification site as Ser-484. [PRO:DAN, PMID:9343410]
synonym: "hSP1/iso:1/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P08047-1, Ser-491, MOD:00805" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000598 ! transcription factor Sp1 isoform 1 O-glycosylated 1
relationship: has_part MOD:00805 ! O-(N-acetylamino)glucosyl-L-serine

[Term]
id: PR:000036499
name: transcription factor Sp1 isoform 1 phosphorylated 1 (human)
def: "A transcription factor Sp1 isoform 1 phosphorylated 1 in human." [PMID:2170018, PMID:9525578, PRO:CNA]
comment: Category=organism-modification.
synonym: "hSP1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000599 ! transcription factor Sp1 isoform 1 phosphorylated 1
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:Q01714
name: transcription factor Sp1 (rat)
def: "A transcription factor Sp1 that is encoded in the genome of rat." [OMA:Q01714, PANTHER:PTHR23235:SF4, PRO:DNx]
comment: Category=organism-gene.
synonym: "Sp1" RELATED Gene-based [UniProtKB:Q01714]
synonym: "rSP1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q01714
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000133 ! transcription factor Sp1
relationship: has_gene_template RGD:3738 ! Sp1 (rat)

[Term]
id: PR:000045654
name: transcription factor Sp1 phosphorylated 1 (human)
def: "A transcription factor Sp1 (human) that has been phosphorylated at the position equivalent to Thr-739 of the amino acid sequence represented by UniProtKB:P08047-1. Example: UniProtKB:P08047-1, Thr-739, MOD:00047." [PMID:22266860, iPTMnet:P08047]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:22266860). Status=unreviewed.
synonym: "hSP1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P08047-1, Thr-739, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P08047 ! transcription factor Sp1 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000036503
name: transcription factor Sp1 isoform 1 sumoylated 1 (human)
def: "A transcription factor Sp1 isoform 1 sumoylated 1 in human. UniProtKB:P08047-1, Lys-16, MOD:01149." [PMID:16407261, PRO:CNA]
comment: Category=organism-modification.
synonym: "hSP1/iso:1/Sumo:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P08047-1, Lys-16, MOD:01149" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000603 ! transcription factor Sp1 isoform 1 sumoylated 1
relationship: has_part MOD:01149 ! sumoylated lysine

[Term]
id: PR:000049324
name: transcription factor Sp1, initiator methionine removed form (human)
def: "A transcription factor Sp1 (human) that has had the initiator methionine removed. UniProtKB:P08047, 2-785." [PRO:DNx, Reactome:R-HSA-1592223]
comment: Category=organism-modification.
synonym: "hSP1/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000047137" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P08047, 2-785" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1592223 "PR:000049324 located_in GO:0005654"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P08047 ! transcription factor Sp1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000025441
name: transcription factor Sp1 proteolytic cleavage product
def: "A transcription factor Sp1 that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "SP1/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000000133 ! transcription factor Sp1

[Term]
id: PR:000000596
name: transcription factor Sp1 isoform 1 acetylated 1
def: "A transcription factor Sp1 isoform 1 acetylated form that has been acetylated by PCAF." [PRO:CNA]
comment: Category=modification.
synonym: "SP1/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000490 ! transcription factor Sp1 isoform 1 acetylated form
relationship: has_part MOD:00394 ! acetylated residue

[Term]
id: PR:000000602
name: transcription factor Sp1 isoform 1 phosphorylated 4
def: "A transcription factor Sp1 isoform 1 phosphorylated form in which the phosphorylation occurs at the first serine/threonine stretch by ATM kinase in response to DNA damage." [PMID:18171990]
comment: Category=modification.
synonym: "SP1/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000493 ! transcription factor Sp1 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000000603
name: transcription factor Sp1 isoform 1 sumoylated 1
def: "A transcription factor Sp1 isoform 1 sumoylated form that has a SUMO protein covalently linked to a Lys residue at the consensus motif VKIE within the N-terminal inhibitory domain. Example: UniProtKB:P08047-1, Lys-16, MOD:01149." [PMID:16407261]
comment: Category=modification.
synonym: "SP1/iso:1/Sumo:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000494 ! transcription factor Sp1 isoform 1 sumoylated form
relationship: has_part MOD:01149 ! sumoylated lysine

[Term]
id: PR:000000600
name: transcription factor Sp1 isoform 1 phosphorylated 2
def: "A transcription factor Sp1 isoform 1 phosphorylated form in which the phosphorylation occurs at a Thr residue within the C-terminal region by casein kinase II. Example: UniProtKB:P08047-1, Thr-579, MOD:00047." [PMID:9153193]
comment: Category=modification.
synonym: "SP1/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000493 ! transcription factor Sp1 isoform 1 phosphorylated form
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000000601
name: transcription factor Sp1 isoform 1 phosphorylated 3
def: "A transcription factor Sp1 isoform 1 phosphorylated form in which the phosphorylation occurs at the Ser residue within the CyclinA/cdk2 phosphorylation site (QPSP sequence). Phosphorylation at this site induces removal of the inhibitory domain by proteolytic processing and activation of transcription activity. Example: UniProtKB:P08047-1, Ser-59, MOD:00046." [PMID:18239466]
comment: Category=modification.
synonym: "SP1/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000493 ! transcription factor Sp1 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000028671
name: transcription factor Sp1 isoform 1 acetylated 2
def: "A transcription factor Sp1 isoform 1 that has been acetylated on a Lys residue within the conserved sequence SDHLSKHI in the most C-terminal zinc finger. Example: UniProtKB:P08047-1, Lys-703, MOD:00064." [PMID:16478997, PRO:PD]
comment: Category=modification.
synonym: "SP1/iso:1/Ac:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000380 ! transcription factor Sp1 isoform 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000028672
name: transcription factor Sp1 isoform 1 acetylated 2 (human)
def: "A transcription factor Sp1 isoform 1 acetylated 2 in human. UniProtKB:P08047-1, Lys-703, MOD:00064." [PMID:16478997, PRO:PD]
comment: Category=organism-modification. Acetylase=("EP300"; PR:Q09472; Lys-703).
synonym: "hSP1/iso:1/Ac:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P08047-1, Lys-703, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028671 ! transcription factor Sp1 isoform 1 acetylated 2
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:P08047-3
name: transcription factor Sp1 isoform h3 (human)
def: "A transcription factor Sp1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08047-3." [PRO:DNx, UniProtKB:P08047]
comment: Category=organism-sequence.
synonym: "hSP1/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "transcription factor Sp1 isoform Sp1c (human)" EXACT [UniProtKB:P08047]
xref: UniProtKB:P08047-3
is_a: PR:P08047 ! transcription factor Sp1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P08047-2
name: transcription factor Sp1 isoform h2 (human)
def: "A transcription factor Sp1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08047-2." [PRO:DNx, UniProtKB:P08047]
comment: Category=organism-sequence.
synonym: "hSP1/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "transcription factor Sp1 isoform Sp1b (human)" EXACT [UniProtKB:P08047]
xref: UniProtKB:P08047-2
is_a: PR:P08047 ! transcription factor Sp1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P08047-1
name: transcription factor Sp1 isoform 1 (human)
def: "A transcription factor Sp1 isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P08047]
comment: Category=organism-sequence.
synonym: "hSP1/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "transcription factor Sp1 isoform Sp1a (human)" EXACT [UniProtKB:P08047]
xref: UniProtKB:P08047-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000380 ! transcription factor Sp1 isoform 1

[Term]
id: PR:000000380
name: transcription factor Sp1 isoform 1
def: "A transcription factor Sp1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08047-1 or a 1:1 ortholog thereof." [PMID:10570957, PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "SP1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000133 ! transcription factor Sp1

[Term]
id: PR:O89090-1
name: transcription factor Sp1 isoform 1 (mouse)
def: "A transcription factor Sp1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:O89090]
comment: Category=organism-sequence.
synonym: "mSP1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O89090-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000380 ! transcription factor Sp1 isoform 1

[Term]
id: PR:Q90WR9
name: transcription factor (chicken)
def: "A transcription factor Sp1 that is encoded in the genome of chicken." [OMA:Q90WR9, PRO:DAN]
comment: Category=organism-gene.
synonym: "chick-SP1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q90WR9
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000000133 ! transcription factor Sp1
relationship: has_gene_template CGNC:49253 ! SP1 (chicken)

[Term]
id: PR:P08047
name: transcription factor Sp1 (human)
def: "A transcription factor Sp1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P08047]
comment: Category=organism-gene.
synonym: "SP1" RELATED Gene-based [UniProtKB:P08047]
synonym: "hSP1" EXACT PRO-short-label [PRO:DNx]
synonym: "TSFP1" RELATED Gene-based [UniProtKB:P08047]
xref: UniProtKB:P08047
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000133 ! transcription factor Sp1
relationship: has_gene_template HGNC:11205 ! SP1 (human)

[Term]
id: PR:O89090
name: transcription factor Sp1 (mouse)
def: "A transcription factor Sp1 that is encoded in the genome of mouse." [OMA:O89090, PRO:DNx]
comment: Category=organism-gene.
synonym: "Sp1" RELATED Gene-based [UniProtKB:O89090]
synonym: "mSP1" EXACT PRO-short-label [PRO:DNx]
synonym: "specificity protein 1 (mouse)" EXACT [UniProtKB:O89090]
xref: UniProtKB:O89090
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000133 ! transcription factor Sp1
relationship: has_gene_template MGI:98372 ! Sp1 (mouse)

[Term]
id: PR:000000133
name: transcription factor Sp1
def: "A transcription factor Sp that is a translation product of the human SP1 gene or a 1:1 ortholog thereof. It comprises the exons that code for an N-terminal inhibitory domain, two serine/threonine stretches adjacent to activation domains and three zinc fingers." [PRO:CNA]
comment: Category=gene.
synonym: "SP1" EXACT PRO-short-label [PRO:DNx]
synonym: "TSFP1" RELATED Gene-based []
xref: PIRSF:PIRSF500820
xref: PANTHER:PTHR23235:SF4
is_a: PR:000000032 ! transcription factor Sp

[Term]
id: PR:O89090-2
name: transcription factor Sp1 isoform m2 (mouse)
def: "A transcription factor Sp1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O89090-2." [PRO:DNx, UniProtKB:O89090]
comment: Category=organism-sequence.
synonym: "mSP1/iso:m2" EXACT PRO-short-label [PRO:DNx]
synonym: "transcription factor Sp1 isoform Sp1-S (mouse)" EXACT [UniProtKB:O89090]
xref: UniProtKB:O89090-2
is_a: PR:O89090 ! transcription factor Sp1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000036500
name: transcription factor Sp1 isoform 1 phosphorylated 2 (human)
def: "A transcription factor Sp1 isoform 1 phosphorylated 2 in human. UniProtKB:P08047-1, Thr-579, MOD:00047." [PMID:9153193, PRO:CNA]
comment: Category=organism-modification.
synonym: "hSP1/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P08047-1, Thr-579, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000600 ! transcription factor Sp1 isoform 1 phosphorylated 2
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000036501
name: transcription factor Sp1 isoform 1 phosphorylated 3 (human)
def: "A transcription factor Sp1 isoform 1 phosphorylated 3 in human. UniProtKB:P08047-1, Ser-59, MOD:00046." [PMID:17049555, PMID:18239466, PRO:CNA]
comment: Category=organism-modification.
synonym: "hSP1/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P08047-1, Ser-59, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000601 ! transcription factor Sp1 isoform 1 phosphorylated 3
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000036502
name: transcription factor Sp1 isoform 1 phosphorylated 4 (human)
def: "A transcription factor Sp1 isoform 1 phosphorylated 4 in human." [PMID:18171990, PRO:CNA]
comment: Category=organism-modification.
synonym: "hSP1/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000602 ! transcription factor Sp1 isoform 1 phosphorylated 4
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000000494
name: transcription factor Sp1 isoform 1 sumoylated form
def: "A transcription factor Sp1 isoform 1 that includes at least one sumoylated lysine." [PRO:CNA]
comment: Category=modification.
synonym: "SP1/iso:1/SumoLys+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:01149 ! sumoylated lysine
intersection_of: PR:000000380 ! transcription factor Sp1 isoform 1

[Term]
id: PR:000000493
name: transcription factor Sp1 isoform 1 phosphorylated form
def: "A transcription factor Sp1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "SP1/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000380 ! transcription factor Sp1 isoform 1

[Term]
id: PR:000000492
name: transcription factor Sp1 isoform 1 glycosylated form
def: "A transcription factor Sp1 isoform 1 that includes at least one glycosylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "SP1/iso:1/GlycoRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00693 ! glycosylated residue
intersection_of: PR:000000380 ! transcription factor Sp1 isoform 1

[Term]
id: PR:000000490
name: transcription factor Sp1 isoform 1 acetylated form
def: "A transcription factor Sp1 isoform 1 that includes at least one acetylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "SP1/iso:1/AcRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00394 ! acetylated residue
intersection_of: PR:000000380 ! transcription factor Sp1 isoform 1

[Term]
id: PR:000000598
name: transcription factor Sp1 isoform 1 O-glycosylated 1
def: "A transcription factor Sp1 isoform 1 glycosylated form that has terminal O-linked N-acetylglucosamines. Example: UniProtKB:P08047-1, Ser-491, MOD:00805." [PMID:11371615, PRO:CNA, PRO:DAN]
comment: Category=modification.
synonym: "SP1/iso:1/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000492 ! transcription factor Sp1 isoform 1 glycosylated form
relationship: has_part MOD:00805 ! O-(N-acetylamino)glucosyl-L-serine

[Term]
id: PR:000000599
name: transcription factor Sp1 isoform 1 phosphorylated 1
def: "A transcription factor Sp1 isoform 1 phosphorylated form in which the phosphorylation occurs within the N-terminal activation domains by a DNA-dependent protein kinase." [PMID:2170018]
comment: Category=modification.
synonym: "SP1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000493 ! transcription factor Sp1 isoform 1 phosphorylated form
relationship: has_part MOD:00696 ! phosphorylated residue